Results 11 to 20 of about 3,741 (219)
Caveolins: Targeting Pro-survival Signaling in the Heart and Brain [PDF]
Frontiers in Physiology, 2012 The present review discusses intracellular signaling moieties specific to membrane lipid rafts (MLRs) and the scaffolding proteins caveolin and introduces current data promoting their potential role in the treatment of pathologies of the heart and brain.
Creed M. Stary +5 more
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Caveolae and caveolins role in health and disease [PDF]
Кардиоваскулярная терапия и профилактика, 2008 Discovered more than 50 years ago, caveolae for a long time have remained enigmatic plasmalemmal organelles. They were described as 50-100-nm invaginations of the plasma membrane observed using electron microscopy.
R. I. Voroblev +4 more
doaj +1 more source
Caveolae, caveolins, cavins and endothelial cell function: new insights
Frontiers in Physiology, 2012 Caveolae are cholesterol and glycosphingolipid-rich flask-shaped invaginations of the plasma membrane which are particularly abundant in vascular endothelium and present in all other cell types of the cardiovascular system, including vascular smooth ...
Grzegorz eSowa
doaj +2 more sources
Endocytic crosstalk: cavins, caveolins, and caveolae regulate clathrin-independent endocytosis.
PLoS Biology, 2014 Several studies have suggested crosstalk between different clathrin-independent endocytic pathways. However, the molecular mechanisms and functional relevance of these interactions are unclear.
Natasha Chaudhary +10 more
doaj +2 more sources
PLoS ONE, 2017 Caveolae are membrane invaginations present at high densities in muscle and fat. Recent work has demonstrated that myocardin family coactivators (MYOCD, MKL1), which are important for contractile differentiation and cell motility, increase caveolin (CAV1,
Baoyi Zhu +7 more
doaj +3 more sources
Caveolins/caveolae protect adipocytes from fatty acid-mediated lipotoxicity [PDF]
Journal of Lipid Research, 2011 Mice and humans lacking functional caveolae are dyslipidemic and have reduced fat stores and smaller fat cells. To test the role of caveolins/caveolae in maintaining lipid stores and adipocyte integrity, we compared lipolysis in caveolin-1 (Cav1)-null ...
Tova Meshulam +4 more
doaj +2 more sources
Mechanical Control of Cell Migration by the Metastasis Suppressor Tetraspanin CD82/KAI1
Cells, 2021 The plasma membrane is a key actor of cell migration. For instance, its tension controls persistent cell migration and cell surface caveolae integrity. Then, caveolae constituents such as caveolin-1 can initiate a mechanotransduction loop that involves ...
Laura Ordas +14 more
doaj +1 more source
Functional Interaction Between Caveolin 1 and LRRC8-Mediated Volume-Regulated Anion Channel
Frontiers in Physiology, 2021 Volume-regulated anion channel (VRAC), constituted by leucine-rich repeat-containing 8 (LRRC8) heteromers, is crucial for volume homeostasis in vertebrate cells.
Mikel Rezola +5 more
doaj +1 more source
A bioinformatics study concerning structural and functional properties of human caveolin proteins [PDF]
Journal of the Serbian Chemical Society, 2014 We performed a bioinformatics study to predict and compare the structural and functional properties of human caveolins: caveolin-1, -2 and -3. The computed local physico-chemical properties, predictions of their secondary structure elements and ...
Isvoran Adriana +7 more
doaj +1 more source
Physiological and pathological roles of caveolins in the central nervous system [PDF]
Trends in NeurosciencesAndré Obenaus +2 more
exaly +2 more sources