Coactivation of CB1 and GPR55 promotes GABA release and motor behavior at striatonigral terminals through increased dimerization induced by CB1 activation [PDF]
Frontiers in Molecular NeuroscienceCB1 and GPR55 receptors form heteromers in striatal neurons; however, the effects of these heteromers on GABA release at their terminals and their impact on motor behavior remain unknown. In this study, we investigate the presence of CB1-GPR55 heteromers
José Arturo Avalos-Fuentes +7 more
doaj +2 more sources
Targeting mechanosensitive cannabinoid receptor 1 with isoflavone prodrugs attenuates atherosclerotic endothelial dysfunction [PDF]
Journal of Biomedical ScienceBackground Despite therapeutic advances, atherosclerosis remains a major global health challenge. Most current treatments target systemic risk factors rather than the diseased vascular wall.
Dai-Jung Chung +12 more
doaj +2 more sources
Novel putative ligands of cannabinoid receptors: synthesis and effects on cell signaling and neuronal functions [PDF]
The Ukrainian Biochemical Journal, 2023 Cannabinoid ligands are known to possess neuroprotective actions and may have utility in the treatment of neurodegeneration. The major targets for cannabinoids include the classical CB1 cannabinoid receptor, as well as the novel cannabinoid receptor ...
J. Senkiv +6 more
doaj +1 more source
Developmental and visual input-dependent regulation of the CB1 cannabinoid receptor in the mouse visual cortex. [PDF]
PLoS ONE, 2013 The mammalian visual system exhibits significant experience-induced plasticity in the early postnatal period. While physiological studies have revealed the contribution of the CB1 cannabinoid receptor (CB1) to developmental plasticity in the primary ...
Taisuke Yoneda +5 more
doaj +1 more source
iScience, 2022 Summary: While blockade of cannabinoid receptor 1 (CB1) has been shown to attenuate diet-induced obesity (DIO), its relative role in different cell types has not been tested.
Kathryn Miranda +8 more
doaj +1 more source
Cell Death Discovery, 2022 Cannabinoid receptors, CB1 and CB2, have been implicated as emerging targets for cancer therapy. Herein, we investigated the potential regulation mechanism of CB1 and its implications in colorectal cancer.
You-Ming Deng +4 more
doaj +1 more source
Modulation of pilocarpine-induced seizures by cannabinoid receptor 1. [PDF]
PLoS ONE, 2014 Administration of the muscarinic agonist pilocarpine is commonly used to induce seizures in rodents for the study of epilepsy. Activation of muscarinic receptors has been previously shown to increase the production of endocannabinoids in the brain ...
Rebecca L Kow +5 more
doaj +1 more source
High spatio-temporal resolution pollutant measurements of on-board vehicle emissions using ultra-fast response gas analyzers [PDF]
Atmospheric Measurement Techniques, 2018 Existing ultra-fast response engine exhaust emissions analyzers have been adapted for on-board vehicle use combined with GPS data. We present, for the first time, how high spatio-temporal resolution data products allow transient features associated ...
M. Irwin +5 more
doaj +1 more source
Frontiers in Neuroanatomy, 2022 Adult oligodendrocyte progenitor cells (OPCs) give rise to myelinating oligodendrocytes through life and play crucial roles in brain homeostasis and plasticity during health and disease.
Andrea Manterola +18 more
doaj +1 more source
Suppression of CB1 cannabinoid receptor by lentivirus mediated small interfering RNA ameliorates hepatic fibrosis in rats. [PDF]
PLoS ONE, 2012 It is recognized that endogenous cannabinoids, which signal through CB1 receptors in hepatic stellate cells (HSCs), exert a profibrotic effect on chronic liver diseases. In this study, we suppressed CB1 expression by lentivirus mediated small interfering
Si-Wen Chen +7 more
doaj +1 more source