Results 11 to 20 of about 27,120 (180)
Molecules, 2021 Numerous studies have investigated the roles of the type 1 cannabinoid receptor (CB1) in glutamatergic and GABAergic neurons. Here, we used the cell-type-specific CB1 rescue model in mice to gain insight into the organizational principles of plasma ...
Miquel Saumell-Esnaola +6 more
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Toxicological properties of Δ9-tetrahydrocannabinol and cannabidiol
Arhiv za Higijenu Rada i Toksikologiju, 2020 Cannabis sativa L. contains more than 100 phytocannabinoids that can interact with cannabinoid receptors CB1 and CB2. None of the cannabinoid receptor ligands is entirely CB1- or CB2-specific. The effects of cannabinoids therefore differ not just because
Černe Katarina
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The cannabinoid-1 receptor is abundantly expressed in striatal striosomes and striosome-dendron bouquets of the substantia nigra. [PDF]
PLoS ONE, 2018 Presynaptic cannabinoid-1 receptors (CB1-R) bind endogenous and exogenous cannabinoids to modulate neurotransmitter release. CB1-Rs are expressed throughout the basal ganglia, including striatum and substantia nigra, where they play a role in learning ...
Margaret I Davis +7 more
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Cannabinoid CB1 receptors regulate salivation
Scientific Reports, 2022 AbstractSaliva serves multiple important functions within the body that we typically take for granted, such as helping prepare food for swallowing and defense against oral pathogens. Dry mouth is a primary symptom of Sjӧgren’s syndrome and is a side effect of many drug treatments.
Kelsey Andreis +6 more
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Frontiers in Behavioral Neuroscience, 2021 Cannabinoid receptors 1 and 2 (CB1 and CB2, respectively) play an important role in maintaining the integrity of the blood–brain barrier (BBB). On the other hand, BBB dysfunction is a common feature in drug-resistant epilepsy.
María de los Ángeles Nuñez-Lumbreras +12 more
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Expression and functional relevance of cannabinoid receptor 1 in Hodgkin lymphoma. [PDF]
PLoS ONE, 2013 Cannabinoid receptor 1 (CB1) is expressed in certain types of malignancies. An analysis of CB1 expression and function in Hodgkin lymphoma (HL), one of the most frequent lymphomas, was not performed to date.We examined the distribution of CB1 protein in ...
Alexander H Benz +10 more
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Loss of cannabinoid receptor CB1 induces preterm birth. [PDF]
PLoS ONE, 2008 Preterm birth accounting approximate 10% of pregnancies in women is a tremendous social, clinical and economic burden. However, its underlying causes remain largely unknown.
Haibin Wang, Huirong Xie, Sudhansu K Dey
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Hippocampal CB1 Receptors Control Incidental Associations [PDF]
Neuron, 2018 By priming brain circuits, associations between low-salience stimuli often guide future behavioral choices through a process known as mediated or inferred learning. However, the precise neurobiological mechanisms of these incidental associations are largely unknown.
Busquets-Garcia, Arnau +15 more
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Canadian Journal of Pain, 2023 Background Preclinical and clinical evidence suggests that cannabis has potential analgesic properties. However, cannabinoid receptor expression and localization within spinal cord pain processing circuits remain to be characterized across sex and ...
Jessica Parnell +8 more
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Frontiers in Physiology, 2016 The cannabinoid type 1 (CB1) receptor is widely distributed in the brain and peripheral organs where it regulates cellular functions and metabolism. In the brain, CB1 is mainly localized on presynaptic axon terminals but is also found on mitochondria ...
Juan Mendizabal-Zubiaga +23 more
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