Results 61 to 70 of about 27,120 (180)

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, EarlyView.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

Cannabinoid CB1 receptor activation mediates the opposing effects of amphetamine on impulsive action and impulsive choice.

PLoS ONE, 2011
It is well known that acute challenges with psychostimulants such as amphetamine affect impulsive behavior. We here studied the pharmacology underlying the effects of amphetamine in two rat models of impulsivity, the 5-choice serial reaction time task (5-
Joost Wiskerke, Nicky Stoop, Dustin Schetters, Anton N M Schoffelmeer, Tommy Pattij   +4 more
doaj   +1 more source

Metabolic Profiling of CB1 Neutral Antagonists [PDF]

, 2017
PIMSR is among the first neutral antagonists for the CB1R and was demonstrated pharmacologically to bind to the CB1R, yet not alter calcium flux. It was further shown computationally to be able to stabilize both the active and inactive states of CB1R revealing the molecular interactions that mechanistically afford the property of neutral antagonism ...
Herbert H, Seltzman, Rangan, Maitra, Katharine, Bortoff, Jay, Henson, Patricia H, Reggio, Daniel, Wesley, Joseph, Tam   +6 more
openaire   +2 more sources

Cannabidiol and cannabigerol ameliorate steatotic liver disease via phosphocreatine buffering and lysosomal restoration

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) and cannabigerol (CBG) alleviate hepatic steatosis in obese mice by shifting energy buffering towards phosphocreatine and enhancing lysosomal lipid degradation and trafficking. These effects are associated with increased creatine kinase activity and lysobisphosphatidic acid (LBPA) levels, highlighting a previously unrecognised ...
Radka Kočvarová, Shahar Azar, Bella Agranovich, Ifat Abramovich, Saveliy Kirillov, Alina Nemirovski, Saja Baraghithy, Inbar Plaschkes, Emmanuelle Merquiol, Alexander Rouvinski, Galia Blum, Liad Hinden, Joseph Tam   +12 more
wiley   +1 more source

Contribution of Altered Endocannabinoid System to Overactive mTORC1 Signaling in Focal Cortical Dysplasia

Frontiers in Pharmacology, 2019
Alterations of the PI3K/Akt/mammalian target of rapamycin complex 1 (mTORC1) signaling pathway are causally involved in a subset of malformations of cortical development (MCDs) ranging from focal cortical dysplasia (FCD) to hemimegalencephaly and ...
Daniel García-Rincón, Daniel García-Rincón, Javier Díaz-Alonso, Javier Díaz-Alonso, Juan Paraíso-Luna, Juan Paraíso-Luna, Zaira Ortega, Zaira Ortega, José Aguareles, José Aguareles, Adán de Salas-Quiroga, Adán de Salas-Quiroga, Cristina Jou, Inmaculada de Prada, Verónica Martínez-Cerdeño, Eleonora Aronica, Eleonora Aronica, Manuel Guzmán, Manuel Guzmán, María Ángeles Pérez-Jiménez, Ismael Galve-Roperh, Ismael Galve-Roperh   +21 more
doaj   +1 more source

Functional divergence of protein kinase A regulatory subunit Iβ variants: the importance of N3A motifs in PKA regulation

The FEBS Journal, EarlyView.
The regulatory subunit RIβ of protein kinase A occurs in two variants that differ at residue 268 (A268 versus R268). This seemingly small substitution significantly changes cAMP sensitivity, basal kinase activity, and the dynamic behavior of the regulatory domains.
Maximilian Wallbott, Jui‐Hung Weng, Valeria Pane, Yuliang Ma, Jian Wu, Susan S. Taylor, Friedrich W. Herberg   +6 more
wiley   +1 more source

In vivo evaluation of the CB1 allosteric modulator LDK1258 reveals CB1-receptor independent behavioral effects

Pharmacology Biochemistry and Behavior, 2020
In the present study, we examined whether LDK1258, which produces strong CB1 receptor allosteric effects in in vitro assays, would elicit in vivo effects consistent with allosteric activity. In initial studies, LDK1258 reduced food consumption and elicited delayed antinociceptive effects in the chronic constrictive injury of the sciatic nerve (CCI ...
Mohammed, Mustafa, Giulia, Donvito, Lauren, Moncayo, Amelia, Swafford, Justin, Poklis, Ralph, Grauer, Teresa, Olszewska, Bogna, Ignatowska-Jankowska, Debra A, Kendall, Dai, Lu, Aron H, Lichtman   +10 more
openaire   +3 more sources

New insights into Ituglanis (Siluriformes: Trichomycteridae) diversity in Bahia State, eastern Brazil: Description of a new species and conservation status reappraisal

Journal of Fish Biology, EarlyView.
Abstract The northeastern Atlantic Forest of Brazil harbours a remarkable diversity of species of Trichomycteridae, many of which remain poorly understood. This study describes a new species of Ituglanis, endemic to the Ribeirão São Roque, a stream tributary of Rio Piabanha, an affluent of Rio Colônia basin, Bahia State, Brazil.
Paulo J. Vilardo, Axel M. Katz, Wilson J. E. M. Costa   +2 more
wiley   +1 more source

A new catfish species of Microcambeva Costa & Bockmann, 1994 (Siluriformes: Trichomycteridae) from southern Brazil, with a redescription of M. ribeirae Costa, Lima & Bizerril, 2004

Journal of Fish Biology, EarlyView.
Abstract Among the few species of Microcambeva reported as occurring in more than one hydrographic basin, M. ribeirae has been previously listed from both the Ribeira de Iguape and the Guaraqueçaba basins. However, morphological and molecular analyses revealed that the specimens from Guaraqueçaba represent a new species, which is described in this ...
Lucas S. de Medeiros, Igor C. A. Souto‐Santos, Paulo A. Buckup, Juliano Ferrer, Vinicius J. C. Reis, Mario de Pinna, Sergio M. Q. Lima   +6 more
wiley   +1 more source

Energy Transitions in Nigeria: The Evolution of Energy Infrastructure Provision (1800–2015)

Energies, 2016
The provision of energy infrastructure is essential for economic growth, social cohesion, and environmental sustainability. Understanding the multiple functions and services it provides us requires firstly a deeper understanding of the factors that ...
Norbert Edomah, Chris Foulds, Aled Jones
doaj   +1 more source