Results 11 to 20 of about 129,465 (297)

Blockade of CC chemokine receptor 2 suppresses pancreatic cancer progression through the interaction with macrophages in the tumor microenvironment [PDF]

Scientific Reports
Pancreatic ductal adenocarcinoma (PDAC) is the most intractable cancer, demonstrating abundant stroma in the tumor microenvironment (TME). Previously, we reported that CXC chemokines contributed to the progression of PDAC through tumor-stromal ...
Gen Kimura, Hideaki Ijichi, Makoto Sano, Genso Notoya, Koji Miyabayashi, Ryota Takahashi, Takahiro Kishikawa, Mitsuhiro Fujishiro   +7 more
doaj   +2 more sources

Identification of therapeutic targets and prognostic biomarkers among CC chemokines in the pancreatic adenocarcinoma microenvironment

Gastroenterology & Endoscopy, 2023
Pancreatic adenocarcinoma (PAAD), one of the most aggressive and lethal malignant tumors, is correlated with increased morbidity and mortality. CC chemokines can modulate the infiltration of immune cells and affect the clinical outcome of cancer patients.
Xinyuan Liu, Qi Zhang, Tao Mao, Congcong Min, Jing Guo, Cuiping Zhang, Zibin Tian, Xiaoyu Li   +7 more
doaj   +1 more source

The Chemokines CXC, CC and C in the Pathogenesis of COVID-19 Disease and as Surrogates of Vaccine-Induced Innate and Adaptive Protective Responses

Vaccines, 2022
COVID-19 is one of the progressive viral pandemics that originated from East Asia. COVID-19 or SARS-CoV-2 has been shown to be associated with a chain of physio-pathological mechanisms that are basically immunological in nature.
Mojgan Noroozi Karimabad, Gholamhossein Hassanshahi, Nicholas G. Kounis, Virginia Mplani, Pavlos Roditis, Christos Gogos, Maria Lagadinou, Stelios F. Assimakopoulos, Periklis Dousdampanis, Ioanna Koniari   +9 more
doaj   +1 more source

CC and CXC chemokines play key roles in the development of polyomaviruses related pathological conditions

Virology Journal, 2021
It has been reported that polyomaviruses are the microbes which can be a cause of several human pathological conditions including cancers, nephropathy, progressive multifocal leukoencephalopathy and gynaecological disease. Although investigators proposed
Mohammad Hassan Mohammadi, Ashraf Kariminik   +1 more
doaj   +1 more source

Integrated miRNA/cytokine/chemokine profiling reveals severity-associated step changes and principal correlates of fatality in COVID-19

iScience, 2022
Summary: Inflammatory cytokines and chemokines (CC) drive COVID-19 pathology. Yet, patients with similar circulating CC levels present with different disease severity. Here, we determined 171 microRNAomes from 58 hospitalized COVID-19 patients (Cohort 1)
Julie C. Wilson, David Kealy, Sally R. James, Tobias Plowman, Katherine Newling, Christopher Jagger, Kara Filbey, Elizabeth R. Mann, Joanne E. Konkel, Madhvi Menon, Sean B. Knight, Angela Simpson, Aliya Prihartadi, Greg Forshaw, Neil Todd, David R.A. Yates, John R. Grainger, Tracy Hussell, Paul M. Kaye, Nathalie Signoret, Dimitris Lagos   +20 more
doaj   +1 more source

Analysis of therapeutic targets and prognostic biomarkers of CXC chemokines in cervical cancer microenvironment

Cancer Cell International, 2021
Background The tumor microenvironment (TME) has received an increasing amount of attention. CXC chemokines can regulate immune cell transport and tumor cell activity to exert anti-tumor immunity.
Weina Kong, Gang Zhao, Haixia Chen, Weina Wang, Xiaoqian Shang, Qiannan Sun, Fan Guo, Xiumin Ma   +7 more
doaj   +1 more source

Molecular determinants for CC-chemokine recognition by a poxvirus CC-chemokine inhibitor [PDF]

Proceedings of the National Academy of Sciences, 2001
Poxviruses express a family of secreted proteins that bind with high affinity to chemokines and antagonize the interaction with their cognate G protein-coupled receptors (GPCRs). These viral inhibitors are novel in structure and, unlike cellular chemokine receptors, are able to specifically interact with most, if not all, CC-chemokines.
B T, Seet, R, Singh, C, Paavola, E K, Lau, T M, Handel, G, McFadden   +5 more
openaire   +2 more sources

The Value of CXCL1, CXCL2, CXCL3, and CXCL8 as Potential Prognosis Markers in Cervical Cancer: Evidence of E6/E7 from HPV16 and 18 in Chemokines Regulation

Biomedicines, 2023
Cervical cancer (CC) is a serious global health issue, and it is well-known that HPV infection is the main etiological factor that triggers carcinogenesis.
Leonardo Fernandez-Avila, Aribert Maryosly Castro-Amaya, Andrea Molina-Pineda, Rodolfo Hernández-Gutiérrez, Luis Felipe Jave-Suarez, Adriana Aguilar-Lemarroy   +5 more
doaj   +1 more source

Discovery and pharmacophoric characterization of chemokine network inhibitors using phage-display, saturation mutagenesis and computational modelling

Nature Communications, 2023
CC and CXC-chemokines are the primary drivers of chemotaxis in inflammation, but chemokine network redundancy thwarts pharmacological intervention. Tick evasins promiscuously bind CC and CXC-chemokines, overcoming redundancy.
Serena Vales, Jhanna Kryukova, Soumyanetra Chandra, Gintare Smagurauskaite, Megan Payne, Charlie J. Clark, Katrin Hafner, Philomena Mburu, Stepan Denisov, Graham Davies, Carlos Outeiral, Charlotte M. Deane, Garrett M. Morris, Shoumo Bhattacharya   +13 more
doaj   +1 more source

The atypical chemokine receptor ACKR2 is protective against sepsis [PDF]

, 2018
Sepsis is a systemic inflammatory response as a result of uncontrolled infections. Neutrophils are the first cells to reach the primary sites of infection and chemokines play a key role in recruiting neutrophils.
Alves-Filho, José Carlos, Amaral, Flávio Almeida, Borges, Vanessa, Castanheira, Fernanda Vargas E. Silva, Cunha, Fernando Queiroz, Cunha, Thiago Mattar, Donate, Paula Barbim, Graham, Gerard J., Kanashiro, Alexandre, Liew, Foo Y., Melo, Paulo Henrique, Pallas, Kenneth, Ramalho, Fernando Silva, Russo, Remo Castro, Sônego, Fabiane, Teixeira, Mauro Martins   +15 more
core   +1 more source