Results 41 to 50 of about 129,465 (297)

Comparative study of CXC chemokines modulation in brown trout (Salmo trutta) following infection with a bacterial or viral pathogen [PDF]

, 2017
Acknowledgements We would like to acknowledge Richard Paley, Tom Hill and Georgina Rimmer for their collaboration during brown trout infection challenges in CEFAS-Weymouth biosecurity facilities. Bartolomeo Gorgoglione, Stephen W. Feist and Nick G.
Feist, Stephen W., Gorgoglione, Bartolomeo, Secombes, Christopher J., Taylor, Nick G. H., Zahran, Eman, Zou, Jun   +5 more
core   +1 more source

Chemokines and immunity

Einstein (São Paulo)
Chemokines are a large family of small cytokines and generally have low molecular weight ranging from 7 to 15kDa. Chemokines and their receptors are able to control the migration and residence of all immune cells.
Diana Carolina Torres Palomino, Luciana Cavalheiro Marti   +1 more
doaj   +1 more source

Enhanced Levels of Chemokines and Their Receptors in the Colon of Microscopic Colitis Patients Indicate Mixed Immune Cell Recruitment

Mediators of Inflammation, 2015
Microscopic colitis (MC), comprising collagenous colitis (CC) and lymphocytic colitis (LC), is a common cause of chronic diarrhea. Various immune cell infiltrations in the epithelium and lamina propria are seen in MC immunopathology. We compared gene and
Sezin Günaltay, Ashok Kumar Kumawat, Nils Nyhlin, Johan Bohr, Curt Tysk, Olof Hultgren, Elisabeth Hultgren Hörnquist   +6 more
doaj   +1 more source

Perivascular adipose tissue inflammation in vascular disease [PDF]

, 2017
Perivascular adipose tissue (PVAT) plays a critical role in the pathogenesis of cardiovascular disease. In vascular pathologies, perivascular adipose tissue increases in volume and becomes dysfunctional, with altered cellular composition and molecular ...
Guzik, Tomasz J., Nosalski, Ryszard
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

A comprehensive bioinformatics analysis to identify potential prognostic biomarkers among CC and CXC chemokines in breast cancer

Scientific Reports, 2022
Breast cancer (BC) is a major human health problem due to its increasing incidence and mortality rate. CC and CXC chemokines are associated with tumorigenesis and the progression of many cancers.
Hossein Hozhabri, Marziyeh Mazaheri Moghaddam, Madiheh Mazaheri Moghaddam, Ali Mohammadian   +3 more
doaj   +1 more source

Anisakis pegreffii impacts differentiation and function of human dendritic cells [PDF]

, 2018
Human dendritic cells (DCs) show remarkably phenotypic changes when matured in presence of helminth-derived products. These modifications frequently elicited a polarization towards Th2 cells and regulatory T cells thus contributing to immunological ...
Allen, Alonso-Gómez, Annunziato, Aranzamendi, Babal, Baeza, Battisti, Becher, Blanco, Coakley, Cortés, Cvetkovic, D'Amelio, Das Mohapatra, Daschner, Dowling, Entwistle, Gerbe, Giri, Gruden-Movsesijan, Hall, Hartmann, Hiemstra, Iborra, Ivanova, Johnson, Klaver, Kotsias, Kuijk, Lian, Lim, Mattiucci, Mattiucci, Mattiucci, Mattiucci, Mattiucci, Mattiucci, Mattiucci, Mattiucci, Messina, Mladineo, Morris, Motran, Nakahara, Nieuwenhuizen, Pulendran, Rescigno, Rodríguez, Rughetti, Silva, Swofford, Terrazas, Ueno, Umehara, Witkowska, Zizzari   +55 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities

Scientific Reports, 2017
Chemokines function via G-protein coupled receptors in a robust network to recruit immune cells to sites of inflammation. Due to the complexity of this network, targeting single chemokines or receptors has not been successful in inflammatory disease. Dog
Kamayani Singh, Graham Davies, Yara Alenazi, James R. O. Eaton, Akane Kawamura, Shoumo Bhattacharya   +5 more
doaj   +1 more source

ANGIOGENIC AND ANGIOSTATIC CHEMOKINES LEVEL IN NORMAL SYNOVIAL FLUID

Медицинская иммунология, 2014
Chemokines are believed to play an important role in immunopathogenesis of different joint diseases. One of important problems in studies of synovial fluid is determination of normal level of chemokines from control patients.
D. A. Zhebrun, A. L. Maslyanskiy, A. G. Titov, A. P. Patruhin, A. A. Kostareva, N. A. Arsentieva, N. E. Lubimova, A. V. Semenov, Areg A. Totolian   +8 more
doaj   +1 more source