CCL11 promotes hepatocellular carcinoma recurrence after surgery by potentiating immunosuppressive CCR5 + CD206 + M2-like macrophages and promoting tumor invasiveness [PDF]
Cell Death and DiseaseLiver resection is the primary curative treatment for early-stage hepatocellular carcinoma (HCC); however, high recurrence rates remain a major challenge in the absence of effective prognostic and preventive strategies.
Jiaqi Wang +12 more
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JHEP Reports, 2023 Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is characterised by accelerated lipid deposition, aberrant inflammation, and excessive extracellular matrix production in the liver.
Zilong Li, Xiulian Miao
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Eotaxin-1/CCL11 promotes cellular senescence in human-derived fibroblasts through pro-oxidant and pro-inflammatory pathways [PDF]
Frontiers in Immunology, 2023 IntroductionEotaxin-1/CCL11 is a pivotal chemokine crucial for eosinophil homing to the lungs of asthmatic patients. Recent studies also suggest that CCL11 is involved in the aging process, as it is upregulated in elderly, and correlated with shorter ...
Florencia Maria Barbé-Tuana
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Effect of CCL11 on In Vitro Myogenesis and Its Clinical Relevance for Sarcopenia in Older Adults [PDF]
Endocrinology and Metabolism, 2021 Background The C-C motif chemokine ligand 11 (CCL11) has been receiving attention as a potential pro-aging factor. Accordingly, it may be involved in muscle metabolism and sarcopenia, a key component of aging phenotypes.
Da Ae Kim +9 more
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Revisiting the Role of Eotaxin-1/CCL11 in Psychiatric Disorders [PDF]
Frontiers in Psychiatry, 2018 Eotaxin-1/CCL11 is a chemokine originally implicated in the selective recruitment of eosinophils into inflammatory sites during allergic reactions, being thoroughly investigated in asthma, allergic rhinitis, and other eosinophil-related conditions ...
Antonio L. Teixeira +5 more
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CCL11 Differentially Affects Post-Stroke Brain Injury and Neuroregeneration in Mice Depending on Age [PDF]
Cells, 2019 CCL11 has recently been shown to differentially affect cell survival under various pathological conditions including stroke. Indeed, CCL11 promotes neuroregeneration in neonatal stroke mice.
Simone Lieschke +10 more
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CCL11, a novel mediator of inflammatory bone resorption
Scientific Reports, 2017 Normal bone homeostasis, which is regulated by bone-resorbing osteoclasts and bone-forming osteoblasts is perturbed by inflammation. In chronic inflammatory disease with disturbed bone remodelling, e.g. rheumatoid arthritis, patients show increased serum
Elin Kindstedt +5 more
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IL-9 induces CCL11 expression via STAT3 signalling in human airway smooth muscle cells. [PDF]
PLoS ONE, 2010 Previous findings support the concept that IL-9 may play a significant role in mediating both pro-inflammatory and changes in airway responsiveness that characterizes the atopic asthmatic state. We previously demonstrated that human airway smooth muscle (
Akira Yamasaki +5 more
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CCL11 is increased in the CNS in chronic traumatic encephalopathy but not in Alzheimer's disease. [PDF]
PLoS ONE, 2017 CCL11, a protein previously associated with age-associated cognitive decline, is observed to be increased in the brain and cerebrospinal fluid (CSF) in chronic traumatic encephalopathy (CTE) compared to Alzheimer's disease (AD).
Jonathan D Cherry +11 more
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CCL11 levels in drug-naive bipolar patients: The role of sex and smoking status
Journal of Affective Disorders Reports, 2020 Background: It has been reported that patients with bipolar disorder (BD) present changes in peripheral levels of the inflammatory cytokine CCL11, particularly at latestages.
Flávio Kapczinski +2 more
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