Results 1 to 10 of about 86,321 (247)

Circulatory CCL2 distinguishes Duchenne muscular dystrophy dogs

Disease Models & Mechanisms
ABSTRACT To establish a minimally invasive approach to studying body-wide muscle inflammation in the canine Duchenne muscular dystrophy (DMD) model, we evaluated 13 cytokines/chemokines in frozen sera from 90 affected (239 sera) and 73 normal (189 sera) dogs (0.00 to 45.2 months of age). Linear mixed-effects model analysis suggested that
Dennis O. Pérez-López, Matthew J. Burke, Chady H. Hakim, James A. Teixeira, Jin Han, Yongping Yue, Zewei Ren, Jianguo Sun, Shi-jie Chen, Roland W. Herzog, Gang Yao, Dongsheng Duan   +11 more
doaj   +3 more sources

The RNA-binding protein HuR modulates the expression of the disease-linked CCL2 rs1024611G-rs13900T haplotype [PDF]

eLife
CC-chemokine ligand 2 (CCL2) is involved in the pathogenesis of several diseases associated with monocyte/macrophage recruitment, such as HIV-associated neurocognitive disorder (HAND), tuberculosis, and atherosclerosis.
Feroz Akhtar, Joselin Hernandez Ruiz, Ya-Guang Liu, Roy G Resendez, Denis Feliers, Liza D Morales, Alvaro Diaz-Badillo, Donna M Lehman, Rector Arya, Juan Carlos Lopez Alvarenga, John Blangero, Ravindranath Duggirala, Srinivas Mummidi   +12 more
doaj   +2 more sources

CCL2 promotes lymphatic metastasis via activating RhoA and Rac1 pathway and predict prognosis to some extent in tongue cancer

Cancer Biology & Therapy, 2023
Background Oral tongue cancer is an extremely malignant tumor with high rate of lymphatic metastasis. Little is known about its invasion and metastasis mechanisms so far. Methods To clarify the main role of CCL2 in tongue cancer progression, we performed
Yuqing Dong, Shuning Zhang, Shuangyuan Zhao, Ming Xuan, Guiquan Zhu, Zhuang Zhang, Weihua Guo   +6 more
doaj   +1 more source

CCL2/CCR2 signaling in cancer pathogenesis [PDF]

Cell Communication and Signaling, 2020
AbstractChemokines are a family of small cytokines, which guide a variety of immune/inflammatory cells to the site of tumor in tumorigenesis. A dysregulated expression of chemokines is implicated in different types of cancer including prostate cancer.
Qiongyu Hao, Jaydutt V. Vadgama, Piwen Wang   +2 more
openaire   +3 more sources

The Vascular Circadian Clock in Chronic Kidney Disease

Cells, 2021
Chronic kidney disease is associated with extremely high cardiovascular mortality. The circadian rhythms (CR) have an impact on vascular function. The disruption of CR causes serious health problems and contributes to the development of cardiovascular ...
Søren Egstrand, Maria L. Mace, Klaus Olgaard, Ewa Lewin   +3 more
doaj   +1 more source

Chemokines during anaphylaxis: the importance of CCL2 and CCL2-dependent chemotactic activity for basophils [PDF]

Clinical and Translational Allergy, 2020
AbstractBackgroundThe role of chemokines in anaphylaxis is unclear.MethodsWe prospectively recruited 49 patients presenting to the emergency department with an acute episode of anaphylaxis and 28 healthy subjects. We measured serum levels of the chemokines CCL2, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL21, CCL22, CCL24, and CCL26, tryptase, the ...
Romana Vantur, Marusa Rihar, Ana Koren, Matija Rijavec, Peter Kopac, Urska Bidovec-Stojkovic, Renato Erzen, Peter Korosec   +7 more
openaire   +3 more sources

RELATIONSHIP BETWEEN THE BLOOD LEVELS OF INFLAMMATORY CYTOKINES AND THE NUMBER OF CIRCULATING TUMOR CELLS WITH RESPONSE TO STANDARD CHEMOTHERAPY IN PATIENTS WITH OVARIAN CANCER

Сибирский онкологический журнал, 2021
Introduction. Serum chemokines are inflammatory mediators, which role is shown in the occurrence and progression of a number of malignant tumors. Produced by white blood cells, stem cells, tumor and endothelial cells, chemokines control their movement ...
S. O. Gening, A. A. Rizvanov, T. V. Abakumova, D. R. Dolgova, D. U. Gafurbaeva, A. R. Rakhmatullina, I. I. Antoneeva, T. P. Gening   +7 more
doaj   +1 more source

CCL2 Blockade Augments Cancer Immunotherapy [PDF]

Cancer Research, 2010
Abstract Altering the immunosuppressive microenvironment that exists within a tumor will likely be necessary for cancer vaccines to trigger an effective antitumor response. Monocyte chemoattractant proteins (such as CCL2) are produced by many tumors and have both direct and indirect immunoinhibitory effects.
Zvi G, Fridlender, George, Buchlis, Veena, Kapoor, Guanjun, Cheng, Jing, Sun, Sunil, Singhal, M Cecilia, Crisanti, Cecilia, Crisanti, Liang-Chuan S, Wang, Daniel, Heitjan, Linda A, Snyder, Steven M, Albelda   +11 more
openaire   +2 more sources

Molecular markers of cardiac fibrosis after myocardial infarction

Фундаментальная и клиническая медицина, 2022
Aim. To perform a screening for molecular markers of cardiac fibrosis upon myocardial infarction.Materials and Methods. We carried out echocardiography-guided endomyocardial biopsy of affected and intact interventricular septum segments of 7 patients ...
O. L. Barbarash, A. G. Kutikhin, T. B. Pecherina, R. S. Tarasov, V. V. Kashtalap, N. V. Fedorova, L. A. Bogdanov, O. N. Hryachkova, D. Yu. Sedykh   +8 more
doaj   +1 more source

CCL2-CCR2 Signaling in Disease Pathogenesis [PDF]

Endocrine, Metabolic & Immune Disorders-Drug Targets, 2015
The role of chemokines and their receptors in controlling several physiological and pathological processes has only become evident in the last couple of years. From a sole function of chemo-attraction, our view on chemokine receptor activation has switched to the regulation of pleiotropic signaling pathways influencing numerous molecular and cellular ...
O'Connor, Tracy, Borsig, Lubor, Heikenwalder, Mathias   +2 more
openaire   +4 more sources