Results 1 to 10 of about 138,616 (334)

CCL2 Polymorphism in Drug-Resistant and Drug-Responsive Patients with Epilepsy in Isfahan, Iran

Medical Laboratory Journal, 2017
Background and objective: Approximately 50 million people worldwide (1% of the worldchr('39')s population) suffer from epilepsy. Among 700 thousand people with epilepsy in Iran, 20% have refractory epilepsy. Accumulation of leukocytes in patientschr('39')
Zahra Rahimi, Mansour Salehi, Abbas Dousti   +2 more
doaj   +1 more source

The RNA-binding protein HuR modulates the expression of the disease-linked CCL2 rs1024611G-rs13900T haplotype [PDF]

eLife
CC-chemokine ligand 2 (CCL2) is involved in the pathogenesis of several diseases associated with monocyte/macrophage recruitment, such as HIV-associated neurocognitive disorder (HAND), tuberculosis, and atherosclerosis.
Feroz Akhtar, Joselin Hernandez Ruiz, Ya-Guang Liu, Roy G Resendez, Denis Feliers, Liza D Morales, Alvaro Diaz-Badillo, Donna M Lehman, Rector Arya, Juan Carlos Lopez Alvarenga, John Blangero, Ravindranath Duggirala, Srinivas Mummidi   +12 more
doaj   +2 more sources

Association of CCL2/CCR2 gene polymorphisms and bladder cancer risk in a hispanic-rich US population. [PDF]

Bladder Cancer
Harmon JF, Santos E, Johnson-Pais TL, Leach RJ, Gelfond J, Mukherjee N, Svatek RS.   +6 more
europepmc   +2 more sources

Chidamide suppresses macrophage-mediated immune evasion and tumor progression in small cell lung cancer by targeting the STAT4/CCL2 signaling pathway [PDF]

Cancer Biology & Medicine
Objective: This study aimed at exploring the effects of the epigenetic regulator, chidamide, on reprogramming the immunosuppressive tumor microenvironment in small cell lung cancer (SCLC), particularly the roles in macrophage polarization and ...
Wenting Liu, Ting Mei, Yantao Jiang, Jingya Wang, Mengjie Li, Liuchun Wang, Zhaoting Meng, Tingting Qin, Dingzhi Huang   +8 more
doaj   +2 more sources

Influence of CCL2-mediated modulation of ALIX in the budding and replication of viruses from multiple families [PDF]

mBio
Signaling by C-C motif ligand 2 (CCL2), a β-chemokine, modulates HIV-1 budding and release by mobilizing ALG-2-interacting protein X (ALIX) from the F-actin cytoskeleton to the cytosol. Immunodepleting CCL2 in the medium sequesters ALIX to F-actin.
Dina Mofed, Anjali Gowripalan, Jacob Berrigan, Pratyush Kumar Das, Nivedita Pujari, David Ajasin, Swati Haldar, John McCullough, Yongwei Zhang, Ganjam V. Kalpana, Anne Bresnick, Margaret Kielian, Duncan W. Wilson, Jinghang Zhang, Kartik Chandran, Vinayaka R. Prasad   +15 more
doaj   +2 more sources

Human Mas-related G protein-coupled receptors-X1 induce chemokine receptor 2 expression in rat dorsal root ganglia neurons and release of chemokine ligand 2 from the human LAD-2 mast cell line [PDF]

, 2013
Primate-specific Mas-related G protein-coupled receptors-X1 (MRGPR-X1) are highly enriched in dorsal root ganglia (DRG) neurons and induce acute pain. Herein, we analyzed effects of MRGPR-X1 on serum response factors (SRF) or nuclear factors of activated
A Breit, A Romero, A Serrano, A Strasser, AA Genazzani, AJ Shaywitz, Andreas Breit, AS Kirshenbaum, B Fioravanti, B Knoll, B Zimmerman, BD Hudson, C Abbadie, C Gaudioso, CH Wang, DA Taylor, DB Wainscott, E Bullitt, E Grazzini, E Utreras, EJ Vallender, ES Burstein, F Jow, FA White, FA White, Franziska Petermann, G Buchwalter, G Kendall, GA Jamieson Jr, H Chen, H Jung, H Jung, H Subramanian, Hans Jürgen Solinski, HB McIlvain, HJ Solinski, Ingrid Boekhoff, J Li, JG Jackson, JH Sun, JJ Moore Jr, K Rothe, K Tatemoto, Kathrin Rothe, KL Pierce, L Hao, L Jenkins, LM Boland, M Brinkmann, N Eijkelkamp, N Katayama, N Kerr, OM Andrisani, P Kunapuli, P Sikand, PC Francel, PM Lembo, PS Puttfarcken, R Maldonado, RD Groth, RD Groth, RJ Davis, Roland Seifert, S Bhangoo, S Dolan, SF Fan, SK Bhangoo, SN Fatakia, SW Ko, Thomas Gudermann, V Baubet, VS Seybold, X Dong, Y Li   +73 more
core   +24 more sources

RELATIONSHIP BETWEEN THE BLOOD LEVELS OF INFLAMMATORY CYTOKINES AND THE NUMBER OF CIRCULATING TUMOR CELLS WITH RESPONSE TO STANDARD CHEMOTHERAPY IN PATIENTS WITH OVARIAN CANCER

Сибирский онкологический журнал, 2021
Introduction. Serum chemokines are inflammatory mediators, which role is shown in the occurrence and progression of a number of malignant tumors. Produced by white blood cells, stem cells, tumor and endothelial cells, chemokines control their movement ...
S. O. Gening, A. A. Rizvanov, T. V. Abakumova, D. R. Dolgova, D. U. Gafurbaeva, A. R. Rakhmatullina, I. I. Antoneeva, T. P. Gening   +7 more
doaj   +1 more source

Molecular markers of cardiac fibrosis after myocardial infarction

Фундаментальная и клиническая медицина, 2022
Aim. To perform a screening for molecular markers of cardiac fibrosis upon myocardial infarction.Materials and Methods. We carried out echocardiography-guided endomyocardial biopsy of affected and intact interventricular septum segments of 7 patients ...
O. L. Barbarash, A. G. Kutikhin, T. B. Pecherina, R. S. Tarasov, V. V. Kashtalap, N. V. Fedorova, L. A. Bogdanov, O. N. Hryachkova, D. Yu. Sedykh   +8 more
doaj   +1 more source

CCL2 promotes lymphatic metastasis via activating RhoA and Rac1 pathway and predict prognosis to some extent in tongue cancer

Cancer Biology & Therapy, 2023
Background Oral tongue cancer is an extremely malignant tumor with high rate of lymphatic metastasis. Little is known about its invasion and metastasis mechanisms so far. Methods To clarify the main role of CCL2 in tongue cancer progression, we performed
Yuqing Dong, Shuning Zhang, Shuangyuan Zhao, Ming Xuan, Guiquan Zhu, Zhuang Zhang, Weihua Guo   +6 more
doaj   +1 more source

Identification of a novel regulatory pathway for PPARα by RNA-seq characterization of the endothelial cell lipid peroxidative injury transcriptome [PDF]

Open Biology, 2019
Endothelial dysfunction caused by endothelial cell injuries is the initiating factor for atherosclerosis (AS), and lipid peroxidative injury is one of a dominant factor for AS pathogenesis.
Fangfang Dou, Beiling Wu, Lin Sun, Jiulin Chen, Te Liu, Zhihua Yu, Chuan Chen   +6 more
doaj   +1 more source