Results 11 to 20 of about 138,616 (334)

CCL2/CCR2 signaling in cancer pathogenesis [PDF]

Cell Communication and Signaling, 2020
AbstractChemokines are a family of small cytokines, which guide a variety of immune/inflammatory cells to the site of tumor in tumorigenesis. A dysregulated expression of chemokines is implicated in different types of cancer including prostate cancer.
Qiongyu Hao, Jaydutt V. Vadgama, Piwen Wang   +2 more
openaire   +3 more sources

Progestins Related to Progesterone and Testosterone Elicit Divergent Human Endometrial Transcriptomes and Biofunctions. [PDF]

, 2020
Progestins are widely used for the treatment of gynecologic disorders and alone, or combined with an estrogen, are used as contraceptives. While their potencies, efficacies and side effects vary due to differences in structures, doses and routes of ...
Balayan, Shayna, Chen, Joseph C, Giudice, Linda C, Greenblatt, Ruth M, Houshdaran, Sahar, Irwin, Juan C, Smith-McCune, Karen, Vallvé-Juanico, Júlia, Vo, Kim Chi   +8 more
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Chemokines during anaphylaxis: the importance of CCL2 and CCL2-dependent chemotactic activity for basophils [PDF]

Clinical and Translational Allergy, 2020
AbstractBackgroundThe role of chemokines in anaphylaxis is unclear.MethodsWe prospectively recruited 49 patients presenting to the emergency department with an acute episode of anaphylaxis and 28 healthy subjects. We measured serum levels of the chemokines CCL2, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL21, CCL22, CCL24, and CCL26, tryptase, the ...
Romana Vantur, Marusa Rihar, Ana Koren, Matija Rijavec, Peter Kopac, Urska Bidovec-Stojkovic, Renato Erzen, Peter Korosec   +7 more
openaire   +3 more sources

CCL2 Blockade Augments Cancer Immunotherapy [PDF]

Cancer Research, 2010
Abstract Altering the immunosuppressive microenvironment that exists within a tumor will likely be necessary for cancer vaccines to trigger an effective antitumor response. Monocyte chemoattractant proteins (such as CCL2) are produced by many tumors and have both direct and indirect immunoinhibitory effects.
Zvi G, Fridlender, George, Buchlis, Veena, Kapoor, Guanjun, Cheng, Jing, Sun, Sunil, Singhal, M Cecilia, Crisanti, Cecilia, Crisanti, Liang-Chuan S, Wang, Daniel, Heitjan, Linda A, Snyder, Steven M, Albelda   +11 more
openaire   +2 more sources

CCL2-CCR2 Signaling in Disease Pathogenesis [PDF]

Endocrine, Metabolic & Immune Disorders-Drug Targets, 2015
The role of chemokines and their receptors in controlling several physiological and pathological processes has only become evident in the last couple of years. From a sole function of chemo-attraction, our view on chemokine receptor activation has switched to the regulation of pleiotropic signaling pathways influencing numerous molecular and cellular ...
O'Connor, Tracy, Borsig, Lubor, Heikenwalder, Mathias   +2 more
openaire   +4 more sources

Cadmium induces CCL2 production in glioblastoma cells via activation of MAPK, PI3K, and PKC pathways

Journal of Immunotoxicology, 2020
Cadmium (Cd) is accumulated in human astrocytes and induces the production of interleukin (IL)-6 and IL-8. Astrocytes are one of the major sources of chemokine C–C motif ligand 2 (CCL2; known as monocyte chemoattractant protein-1 [MCP-1]), in the brain ...
Thitima Kasemsuk, Suttinee Phuagkhaopong, Ruedeemars Yubolphan, Norapat Rungreangplangkool, Pornpun Vivithanaporn   +4 more
doaj   +1 more source

The Vascular Circadian Clock in Chronic Kidney Disease

Cells, 2021
Chronic kidney disease is associated with extremely high cardiovascular mortality. The circadian rhythms (CR) have an impact on vascular function. The disruption of CR causes serious health problems and contributes to the development of cardiovascular ...
Søren Egstrand, Maria L. Mace, Klaus Olgaard, Ewa Lewin   +3 more
doaj   +1 more source

Circulatory CCL2 distinguishes Duchenne muscular dystrophy dogs

Disease Models & Mechanisms
ABSTRACT To establish a minimally invasive approach to studying body-wide muscle inflammation in the canine Duchenne muscular dystrophy (DMD) model, we evaluated 13 cytokines/chemokines in frozen sera from 90 affected (239 sera) and 73 normal (189 sera) dogs (0.00 to 45.2 months of age). Linear mixed-effects model analysis suggested that
Dennis O. Pérez-López, Matthew J. Burke, Chady H. Hakim, James A. Teixeira, Jin Han, Yongping Yue, Zewei Ren, Jianguo Sun, Shi-jie Chen, Roland W. Herzog, Gang Yao, Dongsheng Duan   +11 more
doaj   +3 more sources

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis [PDF]

, 2011
Macrophages abundantly found in the tumor microenvironment enhance malignancy(1). At metastatic sites a distinct population of metastasis associated macrophages (MAMs) promote tumor cell extravasation, seeding and persistent growth(2).
AB Al-Mehdi, AD Borowsky, AJ Minn, AM Havens, B Brandt, B Qian, Bin-Zhi Qian, BS Nielsen, DR Getts, DR Rhodes, Elizabeth A. Kaiser, F Geissmann, F Geissmann, F Geissmann, FK Swirski, H Saji, HP Gerber, Hui Zhang, Jeffrey W. Pollard, JH Im, Jinghang Zhang, Jiufeng Li, JM Carton, Liam R. Campion, Linda A. Snyder, MD Abramoff, P Stern, P Tsui, RT Palframan, T Ueno, T Valkovic, Takanori Kitamura, Y Huang   +32 more
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The Chemokine CCL2 Mediates the Seizure-enhancing Effects of Systemic Inflammation [PDF]

, 2016
Epilepsy is a chronic disorder characterized by spontaneous recurrent seizures. Brain inflammation is increasingly recognized as a critical factor for seizure precipitation, but the molecular mediators of such proconvulsant effects are only partly ...
Allegra, M, Bozzi, Y, Caleo, M, Cerri, C, Genovesi, S, Guglielmotti, A, Ntener, Up, Perry, Vh, Pistillo, F   +8 more
core   +2 more sources