Results 21 to 30 of about 86,321 (247)

CCL2 induces articular chondrocyte MMP expression through ERK and p38 signaling pathways

Osteoarthritis and Cartilage Open, 2021
Objective: In previous studies, we determined an association between increased serum and articular cartilage levels of CCL2 with osteoarthritis (OA) progression, cartilage damage and increased MMP13 in cartilage.
Helen Willcockson, Huseyin Ozkan, Susan Chubinskaya, Richard F. Loeser, Lara Longobardi   +4 more
doaj   +1 more source

Potential Role of Macrophage Phenotypes and CCL2 in the Pathogenesis of Takayasu Arteritis

Frontiers in Immunology, 2021
ObjectivesTo investigate vascular macrophage phenotype as well as vascular and peripheral chemokine (C-C motif) ligand 2 (CCL2) expression during different stages of disease progression in patients with Takayasu Arteritis (TA).MethodsIn this study, 74 ...
Xiufang Kong, Ming Xu, Ming Xu, Xiaomeng Cui, Lingying Ma, Huiyong Cheng, Jun Hou, Xiaoning Sun, Lili Ma, Lindi Jiang, Lindi Jiang   +10 more
doaj   +1 more source

Cadmium induces CCL2 production in glioblastoma cells via activation of MAPK, PI3K, and PKC pathways

Journal of Immunotoxicology, 2020
Cadmium (Cd) is accumulated in human astrocytes and induces the production of interleukin (IL)-6 and IL-8. Astrocytes are one of the major sources of chemokine C–C motif ligand 2 (CCL2; known as monocyte chemoattractant protein-1 [MCP-1]), in the brain ...
Thitima Kasemsuk, Suttinee Phuagkhaopong, Ruedeemars Yubolphan, Norapat Rungreangplangkool, Pornpun Vivithanaporn   +4 more
doaj   +1 more source

Targeting chemoattractant chemokine (C–C motif) ligand 2 derived from astrocytes is a promising therapeutic approach in the treatment of neuromyelitis optica spectrum disorders

Frontiers in Immunology, 2023
IntroductionAquaporin-4 immunoglobulin G (AQP4-IgG)-induced astrocytes injury is a key mechanism in the pathogenesis of neuromyelitis spectrum disorder (NMOSD), and although CCL2 is involved, its specific role has not been reported.
Yupeng Wang, Yupeng Wang, Yupeng Wang, Yupeng Wang, Jiangping Bian, Jiangping Bian, Mengyuan Yao, Mengyuan Yao, Li Du, Li Du, Yun Xu, Haoxiao Chang, Haoxiao Chang, Hengri Cong, Yuzhen Wei, Wangshu Xu, Huabing Wang, Xinghu Zhang, Xingchao Geng, Linlin Yin, Linlin Yin   +20 more
doaj   +1 more source

Recruitment of CCR2+ tumor associated macrophage to sites of liver metastasis confers a poor prognosis in human colorectal cancer

OncoImmunology, 2018
The tumor microenvironment (TME) represents a significant barrier to creating effective therapies for metastatic colorectal cancer (mCRC). In several malignancies, bone marrow derived CCR2+ inflammatory monocytes (IM) are recruited to the TME by ...
Julie G Grossman, Timothy M Nywening, Brian A Belt, Roheena Z Panni, Bradley A Krasnick, David G DeNardo, William G Hawkins, S Peter Goedegebuure, David C Linehan, Ryan C Fields   +9 more
doaj   +1 more source

Mammary tumor-derived CCL2 enhances pro-metastatic systemic inflammation through upregulation of IL1β in tumor-associated macrophages

OncoImmunology, 2017
Patients with primary solid malignancies frequently exhibit signs of systemic inflammation. Notably, elevated levels of neutrophils and their associated soluble mediators are regularly observed in cancer patients, and correlate with reduced survival and ...
Kelly Kersten, Seth B. Coffelt, Marlous Hoogstraat, Niels J.M. Verstegen, Kim Vrijland, Metamia Ciampricotti, Chris W. Doornebal, Cheei-Sing Hau, Max D. Wellenstein, Camilla Salvagno, Parul Doshi, Esther H. Lips, Lodewyk F.A. Wessels, Karin E. de Visser   +13 more
doaj   +1 more source

Toll-Like Receptor 3 as a Recurrence Risk Factor and a Potential Molecular Therapeutic Target in Colorectal Cancer

Clinical and Experimental Gastroenterology, 2020
Tatsuya Yoshida,1 Takuya Miura,1 Tomoh Matsumiya,2 Hidemi Yoshida,2 Hajime Morohashi,1 Yoshiyuki Sakamoto,1 Akira Kurose,3 Tadaatsu Imaizumi,2 Kenichi Hakamada1 1Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine ...
Yoshida T, Miura T, Matsumiya T, Yoshida H, Morohashi H, Sakamoto Y, Kurose A, Imaizumi T, Hakamada K   +8 more
doaj  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Continuous Delivery of Neutralizing Antibodies Elevate CCL2 Levels in Mice Bearing MCF10CA1d Breast Tumor Xenografts

Translational Oncology, 2017
Chemokines are small soluble molecules that play critical roles in wound healing, infection, and cancer progression. In particular, overexpression of the C-C motif chemokine ligand 2 (CCL2) in multiple cancer types correlates with poor patient prognosis.
Min Yao, Curtis Smart, Qingting Hu, Nikki Cheng   +3 more
doaj   +1 more source

MicroRNA-33 suppresses CCL2 expression in chondrocytes [PDF]

Bioscience Reports, 2016
CCL2-mediated macrophage infiltration in articular tissues plays a pivotal role in the development of the osteoarthritis (OA). miRNAs regulate the onset and progression of diseases via controlling the expression of a series of genes. How the CCL2 gene was regulated by miRNAs was still not fully elucidated. In the present study, we demonstrated that the
Wei, Meng, Xie, Qingyun, Zhu, Jun, Wang, Tao, Zhang, Fan, Cheng, Yue, Guo, Dongyang, Wang, Ying, Mo, Liweng, Wang, Shuai   +9 more
openaire   +2 more sources