Results 31 to 40 of about 86,321 (247)

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

The CCL2/CCR2 axis enhances vascular cell adhesion molecule-1 expression in human synovial fibroblasts. [PDF]

PLoS ONE, 2012
Chemokine ligand 2 (CCL2), also known as monocyte chemoattractant protein-1 (MCP-1), belongs to the CC chemokine family that is associated with the disease status and outcomes of osteoarthritis (OA).
Yu-Min Lin, Chin-Jung Hsu, Yuan-Ya Liao, Ming-Chih Chou, Chih-Hsin Tang   +4 more
doaj   +1 more source

CCL2 promotes osteogenesis by facilitating macrophage migration during acute inflammation

Frontiers in Cell and Developmental Biology, 2023
Novel minimally invasive strategies are needed to obtain robust bone healing in complex fractures and bone defects in the elderly population. Local cell therapy is one potential option for future treatment.
Masakazu Toya, Ning Zhang, Ning Zhang, Masanori Tsubosaka, Junichi Kushioka, Qi Gao, Xueping Li, Simon Kwoon-Ho Chow, Stuart B. Goodman, Stuart B. Goodman   +9 more
doaj   +1 more source

Lymph node stromal CCL2 limits antibody responses

Science Immunology, 2020
Lymph node stromal CCL2 limits plasma cell survival via monocyte accumulation and reactive oxygen species and is tuned by vascular permeability.
Dragos C. Dasoveanu, Hyeung Ju Park, Catherine L. Ly, William D. Shipman, Susan Chyou, Varsha Kumar, David Tarlinton, Burkhard Ludewig, Babak J. Mehrara, Theresa T. Lu   +9 more
openaire   +3 more sources

Atheroprotective Roles of Adiponectin via CCL2 Inhibition

Journal of Atherosclerosis and Thrombosis, 2021
Adiponectin (APN) exhibits different atheroprotective effects, and we have previously reported that APN function is modulated by its binding proteins, E-selectin ligand 1, Mac-2 binding protein, and cystatin C. In the present study, we aimed to identify a novel atheroprotective mechanism of APN via C-C motif chemokine 2 (CCL2).We conducted iMAP ...
Fujita, Makoto, Yamamoto, Hiroyasu, Yoshida, Nao, Ono, Runa, Matsuoka, Tetsuro, Kihara, Shinji   +5 more
openaire   +3 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Phenotyping CCL2 Containing Central Amygdala Neurons Controlling Alcohol Withdrawal-Induced Anxiety

Frontiers in Cellular Neuroscience, 2020
Chemokines such as chemokine (C-C motif) ligand 2 (CCL2) play a role in several behaviors, including anxiety-like behavior, but whether neurons are an important source of CCL2 for behavior and how neuronal CCL2 may work to affect behavior are still ...
Kathryn M. Harper, Kathryn M. Harper, Darin J. Knapp, Darin J. Knapp, Caroline A. Todd, Irina Balan, Irina Balan, Laure Aurelian, Laure Aurelian, Hugh E. Criswell, George R. Breese, George R. Breese, George R. Breese   +12 more
doaj   +1 more source

Beneficial impact of CCL2 and CCL12 neutralization on experimental malignant pleural effusion. [PDF]

PLoS ONE, 2013
Using genetic interventions, we previously determined that C-C motif chemokine ligand 2 (CCL2) promotes malignant pleural effusion (MPE) formation in mice.
Antonia Marazioti, Chrysoula A Kairi, Magda Spella, Anastasios D Giannou, Sophia Magkouta, Ioanna Giopanou, Vassilios Papaleonidopoulos, Ioannis Kalomenidis, Linda A Snyder, Dimitrios Kardamakis, Georgios T Stathopoulos   +10 more
doaj   +1 more source

The Chemokine CCL2 Protects Against Methylmercury Neurotoxicity [PDF]

Toxicological Sciences, 2011
Industrial pollution due to heavy metals such as mercury is a major concern for the environment and public health. Mercury, in particular methylmercury (MeHg), primarily affects brain development and neuronal activity, resulting in neurotoxic effects.
Godefroy, David, Gosselin, Romain-Daniel, Yasutake, Akira, Fujimura, Masatake, Combadière, Christophe, Maury-Brachet, Régine, Laclau, Muriel, Rakwal, Randeep, Melik-Parsadaniantz, Stéphane, Bourdineaud, Jean-Paul, Rostène, William   +10 more
openaire   +4 more sources

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source