Results 51 to 60 of about 138,616 (334)

Recruitment of CCR2+ tumor associated macrophage to sites of liver metastasis confers a poor prognosis in human colorectal cancer

OncoImmunology, 2018
The tumor microenvironment (TME) represents a significant barrier to creating effective therapies for metastatic colorectal cancer (mCRC). In several malignancies, bone marrow derived CCR2+ inflammatory monocytes (IM) are recruited to the TME by ...
Julie G Grossman, Timothy M Nywening, Brian A Belt, Roheena Z Panni, Bradley A Krasnick, David G DeNardo, William G Hawkins, S Peter Goedegebuure, David C Linehan, Ryan C Fields   +9 more
doaj   +1 more source

Continuous Delivery of Neutralizing Antibodies Elevate CCL2 Levels in Mice Bearing MCF10CA1d Breast Tumor Xenografts

Translational Oncology, 2017
Chemokines are small soluble molecules that play critical roles in wound healing, infection, and cancer progression. In particular, overexpression of the C-C motif chemokine ligand 2 (CCL2) in multiple cancer types correlates with poor patient prognosis.
Min Yao, Curtis Smart, Qingting Hu, Nikki Cheng   +3 more
doaj   +1 more source

Repression of the Glucocorticoid Receptor Aggravates Acute Ischemic Brain Injuries in Adult Mice. [PDF]

, 2018
Strokes are one of the leading causes of mortality and chronic morbidity in the world, yet with only limited successful interventions available at present.
Concepcion, Katherine R, Fu, Yingjie, Huang, Lei, Li, Yong, Ma, Qingyi, Song, Minwoo A, Xiao, Daliao, Zhang, Lubo, Zhang, Peng   +8 more
core   +2 more sources

MicroRNA-33 suppresses CCL2 expression in chondrocytes [PDF]

Bioscience Reports, 2016
CCL2-mediated macrophage infiltration in articular tissues plays a pivotal role in the development of the osteoarthritis (OA). miRNAs regulate the onset and progression of diseases via controlling the expression of a series of genes. How the CCL2 gene was regulated by miRNAs was still not fully elucidated. In the present study, we demonstrated that the
Wei, Meng, Xie, Qingyun, Zhu, Jun, Wang, Tao, Zhang, Fan, Cheng, Yue, Guo, Dongyang, Wang, Ying, Mo, Liweng, Wang, Shuai   +9 more
openaire   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Mammary tumor-derived CCL2 enhances pro-metastatic systemic inflammation through upregulation of IL1β in tumor-associated macrophages

OncoImmunology, 2017
Patients with primary solid malignancies frequently exhibit signs of systemic inflammation. Notably, elevated levels of neutrophils and their associated soluble mediators are regularly observed in cancer patients, and correlate with reduced survival and ...
Kelly Kersten, Seth B. Coffelt, Marlous Hoogstraat, Niels J.M. Verstegen, Kim Vrijland, Metamia Ciampricotti, Chris W. Doornebal, Cheei-Sing Hau, Max D. Wellenstein, Camilla Salvagno, Parul Doshi, Esther H. Lips, Lodewyk F.A. Wessels, Karin E. de Visser   +13 more
doaj   +1 more source

Phenotyping CCL2 Containing Central Amygdala Neurons Controlling Alcohol Withdrawal-Induced Anxiety

Frontiers in Cellular Neuroscience, 2020
Chemokines such as chemokine (C-C motif) ligand 2 (CCL2) play a role in several behaviors, including anxiety-like behavior, but whether neurons are an important source of CCL2 for behavior and how neuronal CCL2 may work to affect behavior are still ...
Kathryn M. Harper, Kathryn M. Harper, Darin J. Knapp, Darin J. Knapp, Caroline A. Todd, Irina Balan, Irina Balan, Laure Aurelian, Laure Aurelian, Hugh E. Criswell, George R. Breese, George R. Breese, George R. Breese   +12 more
doaj   +1 more source

Beneficial impact of CCL2 and CCL12 neutralization on experimental malignant pleural effusion. [PDF]

PLoS ONE, 2013
Using genetic interventions, we previously determined that C-C motif chemokine ligand 2 (CCL2) promotes malignant pleural effusion (MPE) formation in mice.
Antonia Marazioti, Chrysoula A Kairi, Magda Spella, Anastasios D Giannou, Sophia Magkouta, Ioanna Giopanou, Vassilios Papaleonidopoulos, Ioannis Kalomenidis, Linda A Snyder, Dimitrios Kardamakis, Georgios T Stathopoulos   +10 more
doaj   +1 more source

Effect of a small molecule inhibitor of nuclear factor-κB nuclear translocation in a murine model of arthritis and cultured human synovial cells [PDF]

, 2005
A small cell-permeable compound, dehydroxymethylepoxyquinomicin (DHMEQ), does not inhibit phosphorylation and degradation of IκB (inhibitor of nuclear factor-κB [NF-κB]) but selectively inhibits nuclear translocation of activated NF-κB.
Kubota, Tetsuo, Miyasaka, Nobuyuki, Nanki, Toshihiro, Umezawa, Kazuo, Wakamatsu, Kyoko   +4 more
core   +2 more sources

Lymph node stromal CCL2 limits antibody responses

Science Immunology, 2020
Lymph node stromal CCL2 limits plasma cell survival via monocyte accumulation and reactive oxygen species and is tuned by vascular permeability.
Dragos C. Dasoveanu, Hyeung Ju Park, Catherine L. Ly, William D. Shipman, Susan Chyou, Varsha Kumar, David Tarlinton, Burkhard Ludewig, Babak J. Mehrara, Theresa T. Lu   +9 more
openaire   +3 more sources