Results 181 to 190 of about 94,786 (284)

Cellular Stress, Inflammation and Barrier Damage in Gut Epithelial Cells Caused by Aspartame

Allergy, EarlyView.
This study shows that aspartame, at dietary‐relevant doses, induces cytotoxicity, cellular distress associated with endoplasmic reticulum stress, oxidative stress, DNA replication and repair mechanism disturbance culminating in epithelial barrier damage.
Yagiz Pat, Duygu Yazici, Can Zeyneloglu, Huseyn Babayev, Sena Ardicli, Asuncion Garci‐Sanchez, Xiangting Bu, Anja Heider, Oliva Giannelli Viscardi, Lihong Chang, Sheri Simmons, Anthony Almada, Christine Avena, Tye Jensen, Raja Dhir, Ismail Ogulur, Cezmi A. Akdis   +16 more
wiley   +1 more source

Novel regulators of hepatic macrophages in liver fibrosis. [PDF]

Front Immunol
Tang X, Bai M, Du X, Wang H, Liu M, Fu X, Zhang H, Liang S, Wang L.   +8 more
europepmc   +1 more source

Bicuculline from <i>Forsythia suspensa</i> attenuates liver fibrosis via TLR4/MD2 inhibition and suppression of MyD88/NF-κB signaling. [PDF]

Comput Struct Biotechnol J
Zhang X, Wu G, Peng S, Xu H, Li K, Huang T, Liu Z.   +6 more
europepmc   +1 more source

Context-dependent contribution of peptidyl arginine deiminase 4 (PAD4) to neutrophil extracellular trap formation and liver injury in acute and chronic hepatotoxicant challenge. [PDF]

Toxicol Sci
Capece GE, Patel AK, Hu D, Roychowdhury T, Hazel B, Kothapalli J, Mac NA, Denorme F, Campbell RA, Poole LG.   +9 more
europepmc   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, EarlyView.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

Dendrobine alleviates CCl₄-induced acute liver injury by inhibiting necroptosis through activation of the Nrf2/PPARγ/SOD2 signaling pathways. [PDF]

Chin Med
Yang Y, Fu X, Tan L, Xian S, Fan N, Gan Q, Nan N, Hu L, Shi J, Wu Q, Zhou S.   +10 more
europepmc   +1 more source

Tumor‐Associated Macrophage‐Derived CXCL1 Promotes Endometrial Cancer Progression Through the CXCR2/NF‐κB Pathway

Cancer Science, EarlyView.
CXCL1 secreted by M2 macrophages induced EMT of EC cells through the CXCR2/NF‐κB pathway; CXCR2 expression was predominantly observed in the epithelial compartment, whereas CXCL1 expression was primarily localized in the stromal region; Neutralization of M2 macrophage‐secreted CXCL1 and inhibiting the NF‐κB pathway can inhibit EC progression in vivo ...
Ruiqi Xia, Dingtian Qi, Boshu Ji, Yisheng Dai, Xianchao Kong   +4 more
wiley   +1 more source

Targeting of specific CCR5-G protein complexes underlies biased signaling by HIV-1 envelope glycoproteins. [PDF]

Cell Commun Signal
Gasser R, Colin P, Jacquemard C, Montagné T, Zhou Z, Pons V, Kostenis E, Galés C, Kellenberger E, Lagane B.   +9 more
europepmc   +1 more source

Gestational Melatonin Supplementation Attenuates Maternal Sleep Deprivation‐Induced Steatohepatitis Susceptibility in Offspring

Cell Proliferation, EarlyView.
Maternal SD during pregnancy enhances the development of diet‐induced NASH in adult offspring of both sexes through an NR4A3‐dependent mechanism, characterised by heightened inflammation and increased apoptosis. Maternal melatonin supplementation effectively alleviates this increased susceptibility to NASH in offspring.
Fei Guo, Zexin Yang, Junsen She, Chen Fang, Yizhi Hu, Hefeng Huang, Ling Gao   +6 more
wiley   +1 more source

Regulatory effects of Sini-San on bile acid homeostasis in the enterohepatic circulation of mice with liver fibrosis. [PDF]

Chin Med
Zhu F, Ding Y, Chen L, Fang R, Huang C, Liu E, Wang Y, Su Y, Ge C.   +8 more
europepmc   +1 more source