Results 41 to 50 of about 76,869 (253)
β2-adrenergic agonists modulate TNF-α induced astrocytic inflammatory gene expression and brain inflammatory cell populations [PDF]
, 2014 Background: The NF-kappa B signaling pathway orchestrates many of the intricate aspects of neuroinflammation. Astrocytic beta(2)-adrenergic receptors have emerged as potential regulators in central nervous system inflammation and are potential targets ...
Aerts, Joeri L +5 more
core +3 more sources
CCL5 derived from platelets increases megakaryocyte proplatelet formation [PDF]
Blood, 2016 Key Points CCL5 increases MK ploidy and subsequent proplatelet formation in a CCR5-dependent manner. CCL5 may act to increase platelet counts during physiological stress.
Kellie R. Machlus +11 more
openaire +2 more sources
What a dog transmissible tumor can teach us about cancer regression
Molecular & Cellular Oncology, 2018 The canine transmissible venereal tumor (CTVT) is one of the few clonally transmissible cancers in nature and the only one that fully regresses following treatment with vincristine.
Ariberto Fassati
doaj +1 more source
Neoplasia: An International Journal for Oncology Research, 2012 The chemokine CCL5 (RANTES) plays active promalignancy roles in breast malignancy. The secretion of CCL5 by breast tumor cells is an important step in its tumor-promoting activities; therefore, inhibition of CCL5 secretion may have antitumorigenic ...
Gali Soria +7 more
doaj +1 more source
CCL5 and CCR5 interaction promotes cell motility in human osteosarcoma. [PDF]
PLoS ONE, 2012 BACKGROUND: Osteosarcoma is characterized by a high malignant and metastatic potential. CCL5 (previously called RANTES) was originally recognized as a product of activated T cells, and plays a crucial role in the migration and metastasis of human cancer ...
Shih-Wei Wang +7 more
doaj +1 more source
Perivascular adipose tissue inflammation in vascular disease [PDF]
, 2017 Perivascular adipose tissue (PVAT) plays a critical role in the pathogenesis of cardiovascular disease. In vascular pathologies, perivascular adipose tissue increases in volume and becomes dysfunctional, with altered cellular composition and molecular ...
Guzik, Tomasz J., Nosalski, Ryszard
core +1 more source
CCL5 mediates breast cancer metastasis and prognosis through CCR5/Treg cells
Frontiers in Oncology, 2022 Background and aimsCCL5 is considered to contribute to the biological function of a variety of cancer types, but its specific mechanism is still unclear.
Juanjuan Qiu +8 more
doaj +1 more source
The effect of down-regulation of CCL5 on lipopolysaccharide-induced WI-38 fibroblast injury: a potential role for infantile pneumonia [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): Aberrant expression of CCL5 has been found in several kinds of inflammatory diseases, and the roles of CCL5 in these diseases have also been reported. However, the role of CCL5 in infantile pneumonia is still unclear. Thus, the function and
Dong Bai, Anbang Han, Shan Cong
doaj +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2019 Background & Aims: Chemokine-mediated immune cell recruitment plays pivotal roles in liver inflammation. C-C motif chemokine ligand 5 (CCL5) has been shown to be responsible for the recruitment of monocytes/macrophages and has been implicated in various ...
Lili Chen +12 more
doaj +1 more source
The atypical chemokine receptor ACKR2 is protective against sepsis [PDF]
, 2018 Sepsis is a systemic inflammatory response as a result of uncontrolled infections. Neutrophils are the first cells to reach the primary sites of infection and chemokines play a key role in recruiting neutrophils.
Alves-Filho, José Carlos +15 more
core +1 more source