Is Location Everything? Regulation of the Endothelial CCM Signaling Complex
Frontiers in Cardiovascular Medicine, 2022 Recent advances have steadily increased the number of proteins and pathways known to be involved in the development of cerebral cavernous malformation (CCM).
Harsha Swamy, Angela J. Glading
doaj +1 more source
Modeling wet deposition and concentration of inorganics over Northeast Asia with MRI-PM/c [PDF]
, 2012 We conducted a regional-scale simulation over Northeast Asia for the year 2006 using an aerosol chemical transport model, with time-varying lateral and upper boundary concentrations of gaseous species predicted by a global stratospheric and tropospheric ...
H. Ueda +7 more
core +1 more source
JCI Insight, 2023 Loss-of-function mutations in cerebral cavernous malformation (CCM) genes and gain-of-function mutation in the MAP3K3 gene encoding MEKK3 cause CCM. Deficiency of CCM proteins leads to the activation of MEKK3-KLF2/4 signaling, but it is not clear how ...
Xi Yang +13 more
doaj +1 more source
Estudios genéticos en pacientes y familias con sospecha de enfermedades neurovasculares hereditarias
Kranion, 2023 Introducción: Las enfermedades neurovasculares minoritarias como CADASIL, cavernomatosis múltiple familiar o arteriopatía de moyamoya requieren un abordaje diagnóstico multidisciplinario que incluya un panel genético.
Sara Banda +21 more
doaj +1 more source
Clinical pharmacology and tolerability of REC-994, a redox-cycling nitroxide compound, in randomized phase 1 dose-finding studies. [PDF]
Pharmacol Res PerspectCerebral cavernous malformation (CCM) pathogenesis involves elevated reactive oxygen species (ROS) levels. REC‐994 restores ROS balance, and in double‐blind, placebo‐controlled, trials in healthy volunteers, had low potential for off‐target adverse effects and pharmacokinetics suitable for phase 2 development.
Alfa R +10 more
europepmc +2 more sources
Upregulation of transmembrane endothelial junction proteins in human cerebral cavernous malformations [PDF]
, 2010 OBJECT: Cerebral cavernous malformations (CCMs) are among the most prevalent cerebrovascular malformations, and endothelial cells seem to play a major role in the disease.
Chappell PM +8 more
core +1 more source
Linkage to the CCM2 Locus and Genetic Heterogeneity in Familial Cerebral Cavernous Malformation [PDF]
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2003 ABSTRACT:Background:Cerebral cavernous malformation (CCM) is a form of intracranial vascular disease that may arise sporadically or be dominantly inherited. Linkage studies have revealed genetic heterogeneity among the dominantly inherited forms suggesting the existence of at least three loci called CCM1, CCM2 and CCM3.Methods:In the present study, we ...
Nicolas, Dupré +10 more
openaire +2 more sources
Systems-wide analysis unravels the new roles of CCM signal complex (CSC)
Heliyon, 2019 Cerebral cavernous malformations (CCMs) are characterized by abnormally dilated intracranial capillaries that result in increased susceptibility to stroke. Three genes have been identified as causes of CCMs; KRIT1 (CCM1), MGC4607 (CCM2) and PDCD10 (CCM3);
Johnathan Abou-Fadel +4 more
doaj +1 more source
The Journal of Clinical Investigation, 2022 The loss function of cerebral cavernous malformation (CCM) genes leads to most CCM lesions characterized by enlarged leaking vascular lesions in the brain.
Zhi Fang +9 more
doaj +1 more source
Chemical data assimilation estimates of continental U.S. ozone and nitrogen budgets during the Intercontinental Chemical Transport Experiment-North America [PDF]
, 2007 Global ozone analyses, based on assimilation of stratospheric profile and ozone column measurements, and NOy predictions from the Real-time Air Quality Modeling System (RAQMS) are used to estimate the ozone and NOy budget over the continental United ...
Al-Saadi, J +23 more
core +2 more sources