Results 81 to 90 of about 3,789 (186)

CCM2 and CCM3 proteins contribute to vasculogenesis and angiogenesis in human placenta.

Histology and histopathology, 2009
Placenta as an ideal model to study angiogenic mechanisms have been established in previous studies. There are two processes, vasculogenesis and angiogenesis, involved in blood vessel formation during placental development. Therefore, blood vessel formation is a crucial issue that might cause vascular malformations. One of the vascular malformations is
Tanriover, Gamze, Seval, Yasemin, Sati, Leyla, Gunel, Murat, Demir, Necdet   +4 more
openaire   +3 more sources

Familiäre Kavernome des Zentralnervensystems: Eine klinische und genetische Studie an 15 deutsche Familien [PDF]

, 2018
Zusammenfassung: 1928 beschrieb Hugo Friedrich Kufs erstmalig eine Familie mit zerebralen, retinalen und kutanen Kavernomen. Mittlerweile wurden über 300 weitere Familien beschrieben.
Andermann, E., Andermann, F., Baumann, C., Bertalanffy, H., Dichgans, J., Elger, C., Hopf, H., Hopf, N., Keidel, M., Kleider, A., Nowak, G., Pfeiffer, R., Rouleau, G., Schramm, J., Siegel, A., Spuck, S., Stefan, H., Sure, U., Verlaan, D.   +18 more
core  

Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy. [PDF]

, 2018
BACKGROUND: Sporadic vascular malformations (VMs) are complex congenital anomalies of blood vessels that lead to stroke, life-threatening bleeds, disfigurement, overgrowth, and/or pain.
Al-Olabi, L, Andrews, KA, Baird, W, Barnacle, A, Biesecker, LG, Bulstrode, N, Clark, G, Dowsett, K, Glover, M, Gordon, K, Hargrave, D, Huson, SM, Jacques, TS, James, G, Joseph, AP, Kangesu, L, Keppler-Noreuil, KM, Khan, A, Kinsler, VA, Knox, R, Kondolf, H, Lindhurst, MJ, Lipson, M, Mahon, C, Mansour, S, Mosica, A, Moss, C, Murthy, A, O'Hara, J, Ong, J, Parker, VE, Patton, EE, Pittman, A, Polubothu, S, Rivière, J-B, Sapp, JC, Sebire, NJ, Semple, RK, Shah, R, Sivakumar, B, Stadnik, P, Thomas, A, Topf, M, Virasami, A, Waelchli, R, Zeng, Z   +45 more
core   +4 more sources

Early Onset Memory Deficit of WMI Rats Compared to Their Nearly Isogenic WLIs Is Reversed by Enriched Environment in Females

Genes, Brain and Behavior, Volume 24, Issue 3, June 2025.
Enriched environment housing reverses memory deficits in middle‐aged WMI females and attenuates deficits in WMI males. Plasma levels of estradiol and hippocampal gene expression followed the same pattern as memory in WMI females following environmental enrichment and may be involved in reversing the effects of aging on cognitive decline.
Michelle T. Ji, Katherine J. Przybyl, Aspen M. Harter, Mariya Nemesh, Sophia T. Jenz, Anna Yamazaki, Chris Kim, Megan K. Mulligan, Hao Chen, Eva E. Redei   +9 more
wiley   +1 more source

Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations

EMBO Molecular Medicine, 2018
Cerebral cavernous malformations (CCMs) are vascular lesions in the central nervous system causing strokes and seizures which currently can only be treated through neurosurgery. The disease arises through changes in the regulatory networks of endothelial
Cécile Otten, Jessica Knox, Gwénola Boulday, Mathias Eymery, Marta Haniszewski, Martin Neuenschwander, Silke Radetzki, Ingo Vogt, Kristina Hähn, Coralie De Luca, Cécile Cardoso, Sabri Hamad, Carla Igual Gil, Peter Roy, Corinne Albiges‐Rizo, Eva Faurobert, Jens P von Kries, Mónica Campillos, Elisabeth Tournier‐Lasserve, W Brent Derry, Salim Abdelilah‐Seyfried   +20 more
doaj   +1 more source

Correlates of Continued Church Membership Intention: An Empirical Study of Religion in Ghana

Journal for the Scientific Study of Religion, Volume 64, Issue 2, Page 123-147, June 2025.
Abstract This study examines the factors influencing continued church membership intention in Ghana, focusing on the key correlates of this behavior. Using structural equation modeling (SEM) the survey data collected were analyzed. The findings highlight charismatic leadership, religious experience, corporate social responsibility, personal needs ...
Andrews Agya Yalley
wiley   +1 more source

CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis [PDF]

Human Molecular Genetics, 2005
Cerebral cavernous malformations (CCMs) are sporadically acquired or inherited vascular lesions of the central nervous system consisting of clusters of dilated thin-walled blood vessels that predispose individuals to seizures and stroke. Familial CCM is caused by mutations in KRIT1 (CCM1) or in malcavernin (CCM2), the murine ortholog of which was ...
Jon S, Zawistowski, Lisa, Stalheim, Mark T, Uhlik, Amy N, Abell, Brooke B, Ancrile, Gary L, Johnson, Douglas A, Marchuk   +6 more
openaire   +2 more sources

Deep-Learning Uncovers certain CCM Isoforms as Transcription Factors

Frontiers in Bioscience-Landmark
Background: Cerebral Cavernous Malformations (CCMs) are brain vascular abnormalities associated with an increased risk of hemorrhagic strokes. Familial CCMs result from autosomal dominant inheritance involving three genes: KRIT1 (CCM1), MGC4607 (CCM2 ...
Jacob Croft, Liyuan Gao, Victor Sheng, Jun Zhang   +3 more
doaj   +1 more source

Targeted Therapies for Slow‐Flow Vascular Malformations

Australasian Journal of Dermatology, Volume 66, Issue 3, Page 142-151, May 2025.
ABSTRACT Advances in genetic sequencing technologies have enabled the identification of key activating somatic variants in cellular signalling pathways involved in the pathogenesis of vascular malformations. Given that these genetic variants are also implicated in the pathogenesis of several cancers, the repurposing of targeted therapies developed in ...
Grace X. Li, Deshan F. Sebaratnam, James P. Pham   +2 more
wiley   +1 more source

Association Analysis of the Circulating Proteome With Sarcopenia‐Related Traits Reveals Potential Drug Targets for Sarcopenia

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 1, February 2025.
ABSTRACT Background Sarcopenia severely affects the physical health of the elderly. Currently, there is no specific drug available for sarcopenia. This study aims to identify pathogenic proteins and druggable targets for sarcopenia through Mendelian randomization (MR)–based analytical framework.
Simin Wen, Siqi Xu, Xizeng Zong, Shifeng Wen, Wende Xiao, Weipeng Zheng, Han Cen, Zhaohua Zhu, Jingyu Xie, Yan Zhang, Changhai Ding, Guangfeng Ruan   +11 more
wiley   +1 more source