Results 81 to 90 of about 65,957 (231)

CCR2 antagonist CCX140-B provides renal and glycemic benefits in diabetic transgenic human CCR2 knockin mice

American Journal of Physiology-Renal Physiology, 2013
Chemokine (C-C motif) receptor 2 (CCR2) is central for the migration of monocytes into inflamed tissues. The novel CCR2 antagonist CCX140-B, which is currently in two separate phase 2 clinical trials in diabetic nephropathy, has recently been shown to reduce hemoglobin A 1c and fasting blood ...
Timothy, Sullivan, Zhenhua, Miao, Daniel J, Dairaghi, Antoni, Krasinski, Yu, Wang, Bin N, Zhao, Trageen, Baumgart, Linda S, Ertl, Andrew, Pennell, Lisa, Seitz, Jay, Powers, Ruiping, Zhao, Solomon, Ungashe, Zheng, Wei, Landin, Boring, Chia-Lin, Tsou, Israel, Charo, Robert D, Berahovich, Thomas J, Schall, Juan C, Jaen   +19 more
openaire   +3 more sources

Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy. [PDF]

, 2019
Many potentially therapeutic molecules have been identified for treating Duchenne muscular dystrophy. However, targeting those molecules only to sites of active pathology is an obstacle to their clinical use.
Bertoni, Carmen, Flores, Ivan, Ramos, Julian, Tidball, James G, Wang, Ying, Wehling-Henricks, Michelle, Welc, Steven S   +6 more
core  

Molecular imaging in experimental pulmonary fibrosis reveals that nintedanib unexpectedly modulates CCR2 immune cell infiltrationResearch in context

EBioMedicine
Summary: Background: Pulmonary fibrosis is a challenging clinical problem with lung pathology featuring immune cell infiltrates, fibroblast expansion, and matrix deposition.
Hasan Farooq, Hannah P. Luehmann, Jeffrey R. Koenitzer, Gyu Seong Heo, Deborah H. Sultan, Devesha H. Kulkarni, Sean P. Gunsten, Rekha M. Sashti, Tao Huang, Amanda R. Keller, Kory J. Lavine, Jeffrey J. Atkinson, Laura M. Wingler, Yongjian Liu, Steven L. Brody   +14 more
doaj   +1 more source

CCR2 knockout ameliorates obesity-induced kidney injury through inhibiting oxidative stress and ER stress.

PLoS ONE, 2019
CCL2/CCR2 signaling is believed to play an important role in kidney diseases. Several studies have demonstrated that blocking of CCR2 has a therapeutic effect on kidney diseases.
Seung Joo Lee, Jeong Suk Kang, Hong Min Kim, Eun Soo Lee, Ji-Hye Lee, Choon Hee Chung, Eun Young Lee   +6 more
doaj   +1 more source

CCL2/CCR2 Axis Promotes the Progression of Salivary Adenoid Cystic Carcinoma via Recruiting and Reprogramming the Tumor-Associated Macrophages

Frontiers in Oncology, 2019
Objective: The present study investigated the roles and underlying mechanism of CCL2/CCR2 axis in the interactions between tumor cells and tumor-associated macrophages (TAMs) during the progression of salivary adenoid cystic carcinoma (SACC).Methods ...
Zihui Yang, Huan Li, Weiqi Wang, Jianying Zhang, Sen Jia, Jun Wang, Jianhua Wei, Delin Lei, Kaijin Hu, Xinjie Yang   +9 more
doaj   +1 more source

CCL2/CCR2: push/pull for migration

Blood, 2009
In this issue of Blood , Luesink and colleagues report that in APL, the induction of massive production CC-chemokines (CCLs) and their receptors (CCRs) in APL cells by differentiating therapy with ATRA or ATO may play an important role in the development of the DS,[1][1] formerly known as ...
openaire   +3 more sources

MicroRNA-155 regulates monocyte chemokine and chemokine receptor expression in Rheumatoid Arthritis [PDF]

, 2016
Objectives: To test the hypothesis that miR-155 regulates monocyte migratory potential via modulation of chemokine and chemokine receptor expression in rheumatoid arthritis (RA); and thereby is associated with disease activity.
Elmesmari, Aziza, Fraser, Alasdair R., Gilchrist, Derek, Kurowska-Stolarska, Mariola, McInnes, Iain B., McSharry, Charles, Stewart, Lynn, Vaughan, Diane, Wood, Claire   +8 more
core   +1 more source

Inflammatory monocytes orchestrate innate antifungal immunity in the lung.

PLoS Pathogens, 2014
Aspergillus fumigatus is an environmental fungus that causes invasive aspergillosis (IA) in immunocompromised patients. Although -CC-chemokine receptor-2 (CCR2) and Ly6C-expressing inflammatory monocytes (CCR2⁺Mo) and their derivatives initiate adaptive ...
Vanessa Espinosa, Anupam Jhingran, Orchi Dutta, Shinji Kasahara, Robert Donnelly, Peicheng Du, Jeffrey Rosenfeld, Ingrid Leiner, Chiann-Chyi Chen, Yacov Ron, Tobias M Hohl, Amariliz Rivera   +11 more
doaj   +1 more source

The Chemokine CCL2 Mediates the Seizure-enhancing Effects of Systemic Inflammation [PDF]

, 2016
Epilepsy is a chronic disorder characterized by spontaneous recurrent seizures. Brain inflammation is increasingly recognized as a critical factor for seizure precipitation, but the molecular mediators of such proconvulsant effects are only partly ...
Allegra, M, Bozzi, Y, Caleo, M, Cerri, C, Genovesi, S, Guglielmotti, A, Ntener, Up, Perry, Vh, Pistillo, F   +8 more
core   +2 more sources

Identifying chemokines as therapeutic targets in renal disease: Lessons from antagonist studies and knockout mice [PDF]

, 2004
Chemokines, in concert with cytokines and adhesion molecules, play multiple roles in local and systemic immune responses. In the kidney, the temporal and spatial expression of chemokines correlates with local renal damage and accumulation of chemokine ...
Abdi R, Anders HJ, Anders HJ, Anders HJ, Bruhl H, Burne-Taney MJ, Feng L, Fituri O, Fujinaka H, Garcia GE, Grone HJ, Keane MP, Mack M, Miura M, Murphy PM, Nath KA, Perez de Lema G, Rollins BJ, Romagnani P, Segerer S, Segerer S, Segerer S, Tang WW, Taub DD, Tesch GH, Tokuda A, Topham PS, Vielhauer V, Vielhauer V, Wada T, Wang Y, Wenzel U, Wu X, Wu X, Zernecke A   +34 more
core   +1 more source