Results 111 to 120 of about 2,257 (136)

Implication of Ccr4-Not complex function in mRNA quality control in Saccharomyces cerevisiae

, 2011
Production of messenger ribonucleoprotein particles (mRNPs) is subjected to quality control (QC). In Saccharomyces cerevisiae, the RNA exosome and its cofactors are part of the nuclear QC machinery that removes, or stalls, aberrant molecules, thereby ...
Jannie Assenholt, John Mouaikel, Torben Heick Jensen, Mathieu Rougemaille, Domenico Libri, Cyril Saguez   +5 more
core   +1 more source

CAF1-knockout mice are more susceptive to lipopolysaccharide-induced acute lung injury

Journal of Inflammation Research, 2016
Jia-Xin Shi,1 Jia-Shu Li,1 Rong Hu,1 Xiao-Min Li,2 Hong Wang3 1Department of Respiratory Medicine, Lianyungang First People’s Hospital, Affiliated Hospital of Xuzhou Medical University, Affiliated Hospital of the Clinical Medical School of Nanjing ...
Shi JX, Li JS, Hu R, Li XM, Wang H
doaj  

Biochemical analysis of the nuclease module of the human Ccr4-Not deadenylase complex [PDF]

, 2015
In eukaryotic cells, the shortening and removal of the poly(A) tail (deadenylation) of cytoplasmic mRNA is a key step in mRNA degradation. The Ccr4-Not complex is well-characterised as a major deadenylase enzyme involved in mRNA deadenylation.
Maryati, Maryati
core  

The CCR4-NOT complex releases PABP from silenced miRNA targets in the absence of deadenylation

, 2013
GW182 family proteins interact with Argonaute proteins and are required for the translational repression, deadenylation and decay of miRNA targets. To elicit these effects, GW182 proteins interact with PABP and the CCR4- NOT deadenylase complex. Although
Zekri, L., Izaurralde, E. ; https://orcid.org/   +1 more
core  

CCR4-NOT deadenylates mRNA associated with RNA-induced silencing complexes in human cells

, 2010
MicroRNAs (miRNAs) repress gene expression posttranscriptionally by inhibiting translation and by expe-diting deadenylation so as to trigger rapid mRNA decay.
Xue Zhang, Xianghua Piao, Joel G. Belasco, Ligang Wu   +3 more
core  

Haploinsufficiency of Cnot3 Aggravates Acid-Induced Acute Lung Injury Likely Through Transcriptional and Post-Transcriptional Upregulation of Pro-Inflammatory Genes

Journal of Inflammation Research
Tomokazu Yamaguchi,1,2,* Ryo Ozawa,2,3,* Takafumi Minato,2 Midori Hoshizaki,4 Yutaro Kammura,1,5 Kazuma Okawara,1,6 Yousef A Khalil,1 Masafumi Nakamura,6 Ken Yamaura,5 Masayuki Fukuda,3 Yumiko Imai,4 Keiji Kuba1,2 1Department of Pharmacology ...
Yamaguchi T, Ozawa R, Minato T, Hoshizaki M, Kammura Y, Okawara K, Khalil YA, Nakamura M, Yamaura K, Fukuda M, Imai Y, Kuba K   +11 more
doaj  

Regulation of Early Lymphocyte Development via mRNA Decay Catalyzed by the CCR4-NOT Complex [PDF]

Development of lymphocytes is precisely regulated by various mechanisms. In addition to transcriptional rates, post-transcriptional regulation of mRNA abundance contributes to differentiation of lymphocytes. mRNA decay is a post-transcriptional mechanism
Yamamoto, Tadashi, Akiyama, Taishin
core  

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CCR4 in cutaneous T-cell lymphoma: Therapeutic targeting of a pathogenic driver

European Journal of Immunology, 2021
Emilio Berti, Silvia Alberti Violetti, Jan Nicolay   +2 more
exaly  

Immunohistochemistry for CCR4 C-terminus predicts CCR4 mutations and mogamulizumab efficacy in adult T-cell leukemia/lymphoma

Journal of Pathology: Clinical Research, 2021
Hiroshi Inagaki, Shigeru Kusumoto, Yuma Sakamoto   +2 more
exaly  

CCR4 as a Therapeutic Target for Cancer Immunotherapy

Cancers, 2021
Osamu Yoshie
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