The architecture of the Schizosaccharomyces pombe CCR4-NOT complex [PDF]
Nature Communications, 2016 CCR4-NOT is a protein complex involved in a variety of important genetic processes. Here, the authors report the mid-resolution structure of this complex, and model the positions and contacts between the subunits, providing structural support for the ...
Marta Ukleja +7 more
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Silencing of CCR4-NOT complex subunits affects heart structure and function [PDF]
Disease Models & Mechanisms, 2020 The identification of genetic variants that predispose individuals to cardiovascular disease and a better understanding of their targets would be highly advantageous.
Lisa Elmén +13 more
doaj +4 more sources
The CCR4-NOT complex contributes to repression of Major Histocompatibility Complex class II transcription [PDF]
Scientific Reports, 2017 The multi-subunit CCR4 (carbon catabolite repressor 4)-NOT (Negative on TATA) complex serves as a central coordinator of all different steps of eukaryotic gene expression.
Alfonso Rodríguez-Gil +9 more
doaj +5 more sources
The Not5 subunit of the ccr4-not complex connects transcription and translation. [PDF]
PLoS Genetics, 2014 Recent studies have suggested that a sub-complex of RNA polymerase II composed of Rpb4 and Rpb7 couples the nuclear and cytoplasmic stages of gene expression by associating with newly made mRNAs in the nucleus, and contributing to their translation and ...
Zoltan Villanyi +8 more
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The Ccr4-Not complex interacts with the mRNA export machinery. [PDF]
PLoS ONE, 2011 The Ccr4-Not complex is a key eukaryotic regulator of gene transcription and cytoplasmic mRNA degradation. Whether this complex also affects aspects of post-transcriptional gene regulation, such as mRNA export, remains largely unexplored.
Shana C Kerr +6 more
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Heterogeneity and complexity within the nuclease module of the Ccr4-Not complex [PDF]
Frontiers in Genetics, 2013 The shortening of the poly(A) tail of cytoplasmic mRNA (deadenylation) is a pivotal step in the regulation of gene expression in eukaryotic cells. Deadenylation impacts on both regulated mRNA decay as well as the rate of mRNA translation.
Gerlof Sebastiaan Winkler +1 more
doaj +3 more sources
Insights into the structure and architecture of the CCR4-NOT complex [PDF]
Frontiers in Genetics, 2014 The CCR4-NOT complex is a highly conserved, multifunctional machinery with a general role in controlling mRNA metabolism. It has been implicated in a number of different aspects of mRNA and protein expression, including mRNA degradation, transcription ...
Kun eXu +4 more
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RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation [PDF]
Nature Communications, 2021 The CCR4-NOT complex is a key regulator of eukaryotic mRNA deadenylation. Here the authors identified the E3 ubiquitin ligase RNF219 as an acetylation-regulated cofactor of the complex, which inhibits mRNA decay through a direct interaction with NOT9.
Fabian Poetz +10 more
doaj +2 more sources
Novel roles of the multifunctional CCR4-NOT complex in post-transcriptional regulation [PDF]
Frontiers in Genetics, 2014 The CCR4-NOT complex is highly conserved gene silencer, and more general functions of the complex have been elucidated at post-transcriptional levels. Specific regulatory proteins, including miRNA-induced silencing complex and its associate protein, bind
Toshifumi eInada, Shiho eMakino
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Insulin-Degrading Enzyme Regulates mRNA Processing and May Interact with the CCR4-NOT Complex [PDF]
CellsInsulin-degrading enzyme is a zinc metalloprotease that degrades low-molecular-weight substrates, including insulin. Ubiquitous expression, high evolutionary conservation, upregulation of Ide in stress situations, and literature findings suggest a ...
Barbara Bertocci +6 more
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