Results 41 to 50 of about 13,668 (163)

Interaction between NANOS2 and the CCR4-NOT deadenylation complex is essential for male germ cell development in mouse. [PDF]

PLoS ONE, 2012
Nanos is one of the evolutionarily conserved proteins implicated in germ cell development and we have previously shown that it interacts with the CCR4-NOT deadenylation complex leading to the suppression of specific RNAs. However, the molecular mechanism
Atsushi Suzuki, Rie Saba, Kei Miyoshi, Yoshinori Morita, Yumiko Saga   +4 more
doaj   +1 more source

Twin Promotes the Maintenance and Differentiation of Germline Stem Cell Lineage through Modulation of Multiple Pathways

Cell Reports, 2015
The central question in stem cell regulation is how the balance between self-renewal and differentiation is controlled at the molecular level. This study uses germline stem cells (GSCs) in the Drosophila ovary to demonstrate that the Drosophila CCR4 ...
Ziwen Fu, Cuiyun Geng, Hui Wang, Zhihao Yang, Changjiang Weng, Hua Li, Lamei Deng, Luping Liu, Nan Liu, Jianquan Ni, Ting Xie   +10 more
doaj   +1 more source

The Ccr4-Not complex is a key regulator of eukaryotic gene expression. [PDF]

Wiley Interdiscip Rev RNA, 2016
The Ccr4‐Not complex is a multisubunit complex present in all eukaryotes that contributes to regulate gene expression at all steps, from production of messenger RNAs (mRNAs) in the nucleus to their degradation in the cytoplasm. In the nucleus it influences the post‐translational modifications of the chromatin template that has to be remodeled for ...
Collart MA.
europepmc   +6 more sources

Ccr4‐Not complex directly regulates transcription elongation

The FASEB Journal, 2010
Many functions have been ascribed to the Ccr4‐Not complex. First described many years ago as a potential regulator of preinitiation complex (PIC) formation, more recently, a large body of evidence indicates it is predominantly cytoplasmic and regulates deadenylation of mRNA and ubiquitylation of substrates in ...
Joseph C Reese, Jennifer A. Kruk, Arnob Dutta, David S Gilmour   +3 more
openaire   +1 more source

CCR4/NOT complex associates with the proteasome and regulates histone methylation [PDF]

Proceedings of the National Academy of Sciences, 2007
The proteasome regulates histone lysine methylation and gene transcription, but how it does so is poorly understood. To better understand this process, we used the epistatic miniarray profile (E-MAP) approach to identify factors that genetically interact with proteasomal subunits.
R Nicholas, Laribee, Yoichiro, Shibata, Douglas P, Mersman, Sean R, Collins, Patrick, Kemmeren, Assen, Roguev, Jonathan S, Weissman, Scott D, Briggs, Nevan J, Krogan, Brian D, Strahl   +9 more
openaire   +2 more sources

Control of immediate early gene expression by CPEB4-repressor complex-mediated mRNA degradation

Genome Biology, 2022
Background Cytoplasmic polyadenylation element-binding protein 4 (CPEB4) is known to associate with cytoplasmic polyadenylation elements (CPEs) located in the 3′ untranslated region (UTR) of specific mRNAs and assemble an activator complex promoting the ...
Fabian Poetz, Svetlana Lebedeva, Johanna Schott, Doris Lindner, Uwe Ohler, Georg Stoecklin   +5 more
doaj   +1 more source

Genome-Wide Mapping of Decay Factor–mRNA Interactions in Yeast Identifies Nutrient-Responsive Transcripts as Targets of the Deadenylase Ccr4

G3: Genes, Genomes, Genetics, 2018
The Ccr4 (carbon catabolite repression 4)-Not complex is a major regulator of stress responses that controls gene expression at multiple levels, from transcription to mRNA decay.
Jason E. Miller, Liye Zhang, Haoyang Jiang, Yunfei Li, B. Franklin Pugh, Joseph C. Reese   +5 more
doaj   +1 more source

The Yeast Ccr4-Not Complex Controls Ubiquitination of the Nascent-associated Polypeptide (NAC-EGD) Complex [PDF]

Journal of Biological Chemistry, 2006
In this work, we determine that the Saccharomyces cerevisiae Ccr4-Not complex controls ubiquitination of the conserved ribosome-associated heterodimeric EGD (enhancer of Gal4p DNA binding) complex, which consists of the Egd1p and Egd2p subunits in yeast and is named NAC (nascent polypeptide-associated complex) in mammals.
Panasenko, Olesya, Landrieux, Emilie, Feuermann, Marc, Finka, Andrija, Paquet, Nicole, Collart, Martine   +5 more
openaire   +3 more sources

Architecture of the ubiquitylation module of the yeast Ccr4-Not complex. [PDF]

Structure, 2015
The Ccr4-Not complex regulates eukaryotic gene expression at multiple levels, including mRNA turnover, translational repression, and transcription. We have studied the ubiquitylation module of the yeast Ccr4-Not complex and addressed how E3 ligase binds cognate E2 and how it is tethered to the complex.
Bhaskar V, Basquin J, Conti E.
europepmc   +4 more sources

Distinct Immunomodulatory Strategies Guide Mesenchymal Stromal/Stem Cell‐Mediated Bone Regeneration

Advanced Science, EarlyView.
Bone regeneration by mesenchymal stem cells is strongly influenced by immune signals. This study shows that priming stem cells with regulatory immune cells or an inflammation‐resolving lipid molecule enhances bone formation through distinct immune pathways.
Salwa Suliman, Carla Alvarez Rivas, Aashish Srivastava, Nora Marek, Kamal Mustafa, Alpdogan Kantarci   +5 more
wiley   +1 more source