Results 61 to 70 of about 13,668 (163)
Cellular Mechanism and Key Insights in Allergen Immunotherapy for Allergic Rhinitis
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Allergic rhinitis (AR) arises from immune responses mediated by immunoglobulin E (IgE) to inhaled allergens, representing one of the most prevalent chronic conditions worldwide. Although AR may not be a serious ailment, it holds clinical relevance as it underpins numerous complications, serves as a major risk factor for suboptimal asthma ...
Zhe Wang +3 more
wiley +1 more source
Role of the Ccr4‐Not Complex in Histone Acetylation
The FASEB Journal, 2012 The Ccr4‐Not complex is a global regulator of gene expression that affects expression both positively and negatively. The complex, conserved from yeast to human, is composed of at least nine subunits. The Ccr4 subunit functions in the control of mRNA deadenylation and transcriptional initiation/elongation.
Swati Mehrotra, Ales Vancura
openaire +1 more source
CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The CCR4-NOT Complex
Journal of Molecular Biology, 2022 The CCR4-NOT deadenylase complex is a major post-transcriptional regulator of eukaryotic gene expression. CNOT7 and CNOT8 are both vertebrate homologs of the yeast CCR4-NOT catalytic subunit Caf1. They are highly similar and are sometimes considered redundant, but Cnot7 and Cnot8 knockout mice exhibit different phenotypes, implying distinct ...
Patrick N, Stoney +3 more
openaire +2 more sources
Mycosis Fungoides Is a Proliferation of Multiple Mutational Subclones
The Journal of Dermatology, EarlyView.ABSTRACT Mycosis fungoides (MF) is a unique type of lymphoma with an excellent prognosis presenting with a wide variety of clinical and histological findings. Recent sophisticated research techniques have revealed that very slow changes in the clinical and histological pictures of one patient over time are due to intratumoral heterogeneity.
Ryoma Honda +2 more
wiley +1 more source
Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits [PDF]
Nucleic Acids Research, 2000 The yeast CCR4-NOT protein complex is a global regulator of RNA polymerase II transcription. It is comprised of yeast NOT1 to NOT5, yeast CCR4 and additional proteins like yeast CAF1. Here we report the isolation of cDNAs encoding human NOT2, NOT3, NOT4 and a CAF1-like factor, CALIF.
Albert, T K +5 more
openaire +5 more sources
The cellular roles of Ccr4-NOT in model and pathogenic fungi – implications for fungal virulence
Frontiers in Genetics, 2013 The fungal Ccr4-NOT complex has been implicated in orchestrating gene expression networks that impact on pathways key for virulence in pathogenic species.
John C. Panepinto +2 more
doaj +1 more source
The CCR4-NOT complex mediates deadenylation and degradation of stem cell mRNAs and promotes planarian stem cell differentiation. [PDF]
PLoS Genetics, 2013 Post-transcriptional regulatory mechanisms are of fundamental importance to form robust genetic networks, but their roles in stem cell pluripotency remain poorly understood.
Jordi Solana +7 more
doaj +1 more source
Allergy, EarlyView.ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter +20 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Immune tolerance prevents inflammation and autoimmunity, with dendritic cells (DCs) playing a key role. Reprogramming DCs towards a tolerogenic state represents a promising therapeutic strategy. Sulforaphane (SFN) has known immunomodulatory effects, but its clinical application is limited by poor stability and ...
María Elena Angarita‐Planchez +6 more
wiley +1 more source
Multi-functional regulation of 4E-BP gene expression by the Ccr4-Not complex. [PDF]
PLoS ONE, 2015 The mechanistic target of rapamycin (mTOR) signaling pathway is highly conserved from yeast to humans. It senses various environmental cues to regulate cellular growth and homeostasis.
Hirokazu Okada +3 more
doaj +1 more source