Results 181 to 190 of about 23,452 (228)

The evolving landscape of regulatory T cells in leukemia: from mechanisms to advanced immunotherapeutic strategies. [PDF]

Front Immunol
Xu H, Zhang X, Zhang J.
europepmc   +1 more source

Immunological impact of tumor-draining lymph node dissection on systemic Th1-like CD4⁺ T cells in patients with early-stage lung cancer. [PDF]

Cancer Immunol Immunother
Kamigaichi A, Kagamu H, Miyata Y, Mimae T, Tsubokawa N, Hirano K, Okada M.   +6 more
europepmc   +1 more source

CCR4 as a Therapeutic Target for Cancer Immunotherapy [PDF]

Cancers, 2021
CCR4 is a chemokine receptor mainly expressed by T cells. It is the receptor for two CC chemokine ligands, CCL17 and CCL22. Originally, the expression of CCR4 was described as highly selective for helper T type 2 (Th2) cells. Later, its expression was extended to other T cell subsets such as regulatory T (Treg) cells and Th17 cells.
Osamu Yoshie
exaly   +3 more sources

CCR4 in cutaneous T-cell lymphoma: Therapeutic targeting of a pathogenic driver [PDF]

European Journal of Immunology, 2021
New treatments are needed for patients with cutaneous T cell lymphoma (CTCL), particularly for advanced mycosis fungoides (MF) and Sezary syndrome (SS).
Emilio Berti, Silvia Alberti Violetti, Jan Nicolay   +2 more
exaly   +2 more sources

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Identification of chemokine receptor CCR4 antagonist

Bioorganic and Medicinal Chemistry Letters, 2005
The present study reports the identification and hits to leads optimization of chemokine receptor CCR4 antagonists. Compound 12 is a high affinity, non-cytotoxic antagonist of CCR4 that blocks the functional activity mediated by the receptor.
John Wityak, Ashok V Purandare
exaly   +3 more sources

Novel interaction between CCR4 and CAF1 in rice CCR4–NOT deadenylase complex

Plant Molecular Biology, 2016
Rice is an important crop in the world. However, little is known about rice mRNA deadenylation, which is an important regulation step of gene expression at the post-transcriptional level. The CCR4-NOT1 complex contains two key components, CCR4 and CAF1, which are the main cytoplasmic deadenylases in eukaryotic cells.
Wei-Lun, Chou, Yue-Lin, Chung, Jhen-Cheng, Fang, Chung-An, Lu   +3 more
openaire   +2 more sources

Internalization of CCR4 and Inhibition of Chemotaxis by K777, a Potent and Selective CCR4 Antagonist

Pharmacology, 2013
CC chemokine receptor 4 (CCR4) is a G protein-coupled receptor that regulates the chemotaxis of Th2 lymphocytes, which are key players in allergic diseases. K777 is a small compound identified in a binding assay using a CCR4 ligand, CCL17. K777 inhibited both CCL17 binding and CCL17-induced chemotaxis in Hut78 cells (IC₅₀: 57 and
Takashi, Sato, Miho, Iwase, Motoki, Miyama, Masato, Komai, Etsuo, Ohshima, Akira, Asai, Hiroshi, Yano, Ichiro, Miki   +7 more
openaire   +2 more sources

Antagonists of CCR4 as Immunomodulatory Agents

Current Topics in Medicinal Chemistry, 2006
The chemokine receptor CCR4 is broadly expressed on cells of the immune system. It is known to play a central role in T cell migration to the thymus, and T cell maturation and education. In addition, CCR4 is known to modulate T cell migration to several sites of inflammation in the body, including the skin, and lungs.
Ashok V, Purandare, John E, Somerville
openaire   +2 more sources