Results 201 to 210 of about 34,716 (235)
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CCR4 Expression in Hodgkin Lymphoma
Blood, 2011Abstract Abstract 2626 In Hodgkin lymphoma (HL) a minority (<1%) of tumor cells is found in a reactive background. The tumor cells shape their environment by the production of several chemokines and cytokines. Production of the chemokine TARC will lead to the attraction of Th2 and Treg cells specifically to involved ...
Lydia Visser +4 more
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Optimization of 2-aminothiazole derivatives as CCR4 antagonists
Bioorganic & Medicinal Chemistry Letters, 2006A series of 2-aminothiazole-derived antagonists of the CCR4 receptor has been synthesized and their affinity for the receptor evaluated using a [(125)I]TARC (CCL17) displacement assay. Optimization of these compounds for potency and pharmacokinetic properties led to the discovery of potent, orally bioavailable antagonists.
Xuemei, Wang +13 more
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Clinical Application of Anti-CCR4 Monoclonal Antibody
Oncology, 2015Mogamulizumab (KW-0761) is a humanized anti-CCR4 monoclonal antibody with a defucosylated Fc region (Potelligent® Technology), which markedly enhances antibody-dependent cellular cytotoxicity by increasing its binding affinity to the Fcγ receptor expressed on effector cells. It is an effective agent for patients with CCR4-positive adult T-cell
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Increased CCR4 expression in active systemic lupus erythematosus
Journal of Leukocyte Biology, 2001AbstractCC chemokine receptor (CCR)4 is selectively expressed on Th2-type Tcells and has been shown to be responsible for Th2-dominant immuneresponses. In this study, we analyzed the expression of CCR4 in activesystemic lupus erythematosus (SLE) patients by FACS analysis usinganti-human CCR4 monoclonal antibody and determined the clinicalrelevance in ...
K, Hase +5 more
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2000
CCR4 receptor antagonists are used for treatment and/or prevention of sepsis and/or septic shock. The antagonists of this invention typically are selected among several classes but preferably are anti-CCR4 antibodies.
APPLIED RESEARCH SYSTEMS +2 more
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CCR4 receptor antagonists are used for treatment and/or prevention of sepsis and/or septic shock. The antagonists of this invention typically are selected among several classes but preferably are anti-CCR4 antibodies.
APPLIED RESEARCH SYSTEMS +2 more
openaire +1 more source
Novel roles of the
The CCR4–NOT complex is a multi‐subunit protein complex evolutionarily conserved across eukaryotes which regulates several aspects of gene expression. A fascinating model is emerging in which this complex acts as a regulation platform, controlling gene products ‘from birth to death’ through the coordination of different cellular machineries involved in
Clément, Chapat, Laura, Corbo
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Expression of CCR4 in adult T-cell leukemia
Leukemia & Lymphoma, 2005Adult T-cell leukemia (ATL) is a malignancy of mature T cells that is etiologically associated with human T-cell leukemia virus type 1 (HTLV-1). The frequent manifestation of ATL is infiltration of leukemic cells into various organs. Besides certain cell adhesion molecules and matrix metalloproteineses, chemokine receptors may play important roles in ...
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The Ccr4-Not complex monitors the translating ribosome for codon optimality
Science, 2020Robert Buschauer +2 more
exaly
CCR4 in cutaneous T‐cell lymphoma: Therapeutic targeting of a pathogenic driver
European Journal of Immunology, 2021Silvia Alberti-Violetti, Emilio Berti
exaly