Results 191 to 200 of about 23,452 (228)

Novel roles of the CCR4–NOT complex

WIREs RNA, 2014
The CCR4–NOT complex is a multi‐subunit protein complex evolutionarily conserved across eukaryotes which regulates several aspects of gene expression. A fascinating model is emerging in which this complex acts as a regulation platform, controlling gene products ‘from birth to death’ through the coordination of different cellular machineries involved in
Clément, Chapat, Laura, Corbo
openaire   +2 more sources

Optimization of CCR4 Antagonists: Side‐Chain Exploration.

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ashok V, Purandare, Honghe, Wan, Aiming, Gao, John, Somerville, Christine, Burke, Wayne, Vaccaro, Xiaoxia, Yang, Kim W, McIntyre, Michael A, Poss   +8 more
openaire   +2 more sources

Discovery and SAR of Trisubstituted Thiazolidinones as CCR4 Antagonists.

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Shelley, Allen, Bradley, Newhouse, Aaron S, Anderson, Benjamin, Fauber, Andrew, Allen, David, Chantry, Christine, Eberhardt, Joshua, Odingo, Laurence E, Burgess   +8 more
openaire   +2 more sources

Structure and assembly of the NOT module of the human CCR4–NOT complex

Nature Structural & Molecular Biology, 2013
The CCR4-NOT deadenylase complex is a master regulator of translation and mRNA stability. Its NOT module orchestrates recruitment of the catalytic subunits to target mRNAs. We report the crystal structure of the human NOT module formed by the CNOT1, CNOT2 and CNOT3 C-terminal (-C) regions.
Andreas Boland, Ying Chen, Tobias Raisch, Stefanie Jonas, Duygu Kuzuoğlu-Öztürk, Lara Wohlbold, Oliver Weichenrieder, Elisa Izaurralde   +7 more
openaire   +3 more sources

The Ccr4-Not Complex: Architecture and Structural Insights

2017
The Ccr4-Not complex is an essential multi-subunit protein complex that plays a fundamental role in eukaryotic mRNA metabolism and has a multitude of different roles that impact eukaryotic gene expression . It has a conserved core of three Not proteins, the Ccr4 protein, and two Ccr4 associated factors, Caf1 and Caf40.
Collart, Martine, Panasenko, Olesya
openaire   +4 more sources

CCR4 Expression in Hodgkin Lymphoma

Blood, 2011
Abstract Abstract 2626 In Hodgkin lymphoma (HL) a minority (<1%) of tumor cells is found in a reactive background. The tumor cells shape their environment by the production of several chemokines and cytokines. Production of the chemokine TARC will lead to the attraction of Th2 and Treg cells specifically to involved ...
Lydia Visser, Myrna van West, Bea Rutgers, Sibrand Poppema, Anke Van Den Berg   +4 more
openaire   +1 more source

Immunohistochemistry for CCR4 C-terminus predicts CCR4 mutations and mogamulizumab efficacy in adult T-cell leukemia/lymphoma

Journal of Pathology: Clinical Research, 2021
Hiroshi Inagaki, Shigeru Kusumoto, Yuma Sakamoto   +2 more
exaly  

CCR4

2011
openaire   +2 more sources

CCR4 ANTAGONISTS

2023
FAN PINGCHEN, LUI REBECCA M, SCAMP RYAN J, YANG JU, WANG YU, ZENG YIBIN, ZHANG PENGLIE   +6 more
openaire   +1 more source

PABP Cooperates with the CCR4-NOT Complex to Promote mRNA Deadenylation and Block Precocious Decay

Molecular Cell, 2018
Joha Park, Vic Narry Kim, Jaechul Lim
exaly