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CCR4 as a Therapeutic Target for Cancer Immunotherapy [PDF]

Cancers, 2021
CCR4 is a chemokine receptor mainly expressed by T cells. It is the receptor for two CC chemokine ligands, CCL17 and CCL22. Originally, the expression of CCR4 was described as highly selective for helper T type 2 (Th2) cells. Later, its expression was extended to other T cell subsets such as regulatory T (Treg) cells and Th17 cells.
Osamu Yoshie
exaly   +3 more sources

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The Ccr4–Not complex

Gene, 2012
The Ccr4-Not complex is a unique, essential and conserved multi-subunit complex that acts at the level of many different cellular functions to regulate gene expression. Two enzymatic activities, namely ubiquitination and deadenylation, are provided by different subunits of the complex.
Collart, Martine, Panasenko, Olesya
openaire   +3 more sources

Mogamulizumab (Anti-CCR4) in HTLV-1–Associated Myelopathy

New England Journal of Medicine, 2018
Human T-lymphotropic virus type 1 (HTLV-1) causes the debilitating neuroinflammatory disease HTLV-1-associated myelopathy-tropical spastic paraparesis (HAM-TSP) as well as adult T-cell leukemia-lymphoma (ATLL). In patients with HAM-TSP, HTLV-1 infects mainly CCR4+ T cells and induces functional changes, ultimately causing chronic spinal cord ...
Tomoo Sato, Ariella L G Coler-Reilly, Eisuke Inoue   +2 more
exaly   +3 more sources

Architecture of the Nuclease Module of the Yeast Ccr4-Not Complex: the Not1-Caf1-Ccr4 Interaction [PDF]

Molecular Cell, 2012
Shortening eukaryotic poly(A) tails represses mRNA translation and induces mRNA turnover. The major cytoplasmic deadenylase, the Ccr4-Not complex, is a conserved multisubunit assembly. Ccr4-Not is organized around Not1, a large scaffold protein that recruits two 3'-5' exoribonucleases, Caf1 and Ccr4.
Jerome Basquin, Bertrand Séraphin, Elena Conti   +2 more
exaly   +4 more sources

North American Adult T-Cell Leukemia/Lymphoma Has Frequent Mutations in CCR4 and Responds in Vitro to a Small Molecule CCR4 Antagonist, CCR4-351

Blood, 2023
Adult T-cell leukemia/lymphoma (ATLL) is a rare and aggressive disease of malignant CD4+ T cells that develops in human T-lymphotropic virus-1 (HTLV-1) carriers. Patients diagnosed with ATLL have the worst survival among all peripheral T-cell lymphomas.
B. Hilda Ye, Eric Liu, Kith Pradhan, Erik Guillen, Urvi A Shah, Aditi Shastri, Gregoire Lauvau, Murali Janakiram, Alejandro Sica, Paul D. Kassner, Amit Verma   +10 more
openaire   +1 more source

Novel interaction between CCR4 and CAF1 in rice CCR4–NOT deadenylase complex

Plant Molecular Biology, 2016
Rice is an important crop in the world. However, little is known about rice mRNA deadenylation, which is an important regulation step of gene expression at the post-transcriptional level. The CCR4-NOT1 complex contains two key components, CCR4 and CAF1, which are the main cytoplasmic deadenylases in eukaryotic cells.
Wei-Lun, Chou, Yue-Lin, Chung, Jhen-Cheng, Fang, Chung-An, Lu   +3 more
openaire   +2 more sources

Identification of chemokine receptor CCR4 antagonist

Bioorganic & Medicinal Chemistry Letters, 2005
The present study reports the identification and hits to leads optimization of chemokine receptor CCR4 antagonists. Compound 12 is a high affinity, non-cytotoxic antagonist of CCR4 that blocks the functional activity mediated by the receptor.
Ashok V, Purandare, Aiming, Gao, Honghe, Wan, John, Somerville, Christine, Burke, Carrie, Seachord, Wayne, Vaccaro, John, Wityak, Michael A, Poss   +8 more
openaire   +2 more sources

Antagonists of CCR4 as Immunomodulatory Agents

Current Topics in Medicinal Chemistry, 2006
The chemokine receptor CCR4 is broadly expressed on cells of the immune system. It is known to play a central role in T cell migration to the thymus, and T cell maturation and education. In addition, CCR4 is known to modulate T cell migration to several sites of inflammation in the body, including the skin, and lungs.
Ashok V, Purandare, John E, Somerville
openaire   +2 more sources

Optimization of CCR4 Antagonists: Side‐Chain Exploration.

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ashok V, Purandare, Honghe, Wan, Aiming, Gao, John, Somerville, Christine, Burke, Wayne, Vaccaro, Xiaoxia, Yang, Kim W, McIntyre, Michael A, Poss   +8 more
openaire   +2 more sources

Internalization of CCR4 and Inhibition of Chemotaxis by K777, a Potent and Selective CCR4 Antagonist

Pharmacology, 2013
CC chemokine receptor 4 (CCR4) is a G protein-coupled receptor that regulates the chemotaxis of Th2 lymphocytes, which are key players in allergic diseases. K777 is a small compound identified in a binding assay using a CCR4 ligand, CCL17. K777 inhibited both CCL17 binding and CCL17-induced chemotaxis in Hut78 cells (IC₅₀: 57 and
Takashi, Sato, Miho, Iwase, Motoki, Miyama, Masato, Komai, Etsuo, Ohshima, Akira, Asai, Hiroshi, Yano, Ichiro, Miki   +7 more
openaire   +2 more sources