Results 191 to 200 of about 21,976 (228)

North American Adult T-Cell Leukemia/Lymphoma Has Frequent Mutations in CCR4 and Responds in Vitro to a Small Molecule CCR4 Antagonist, CCR4-351

Blood, 2023
Adult T-cell leukemia/lymphoma (ATLL) is a rare and aggressive disease of malignant CD4+ T cells that develops in human T-lymphotropic virus-1 (HTLV-1) carriers. Patients diagnosed with ATLL have the worst survival among all peripheral T-cell lymphomas.
B. Hilda Ye, Eric Liu, Kith Pradhan, Erik Guillen, Urvi A Shah, Aditi Shastri, Gregoire Lauvau, Murali Janakiram, Alejandro Sica, Paul D. Kassner, Amit Verma   +10 more
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Novel roles of the CCR4–NOT complex

WIREs RNA, 2014
The CCR4–NOT complex is a multi‐subunit protein complex evolutionarily conserved across eukaryotes which regulates several aspects of gene expression. A fascinating model is emerging in which this complex acts as a regulation platform, controlling gene products ‘from birth to death’ through the coordination of different cellular machineries involved in
Clément, Chapat, Laura, Corbo
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Optimization of CCR4 Antagonists: Side‐Chain Exploration.

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ashok V, Purandare, Honghe, Wan, Aiming, Gao, John, Somerville, Christine, Burke, Wayne, Vaccaro, Xiaoxia, Yang, Kim W, McIntyre, Michael A, Poss   +8 more
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CCR4 Expression in Hodgkin Lymphoma

Blood, 2011
Abstract Abstract 2626 In Hodgkin lymphoma (HL) a minority (<1%) of tumor cells is found in a reactive background. The tumor cells shape their environment by the production of several chemokines and cytokines. Production of the chemokine TARC will lead to the attraction of Th2 and Treg cells specifically to involved ...
Lydia Visser, Myrna van West, Bea Rutgers, Sibrand Poppema, Anke Van Den Berg   +4 more
openaire   +1 more source

Structure and assembly of the NOT module of the human CCR4–NOT complex

Nature Structural & Molecular Biology, 2013
The CCR4-NOT deadenylase complex is a master regulator of translation and mRNA stability. Its NOT module orchestrates recruitment of the catalytic subunits to target mRNAs. We report the crystal structure of the human NOT module formed by the CNOT1, CNOT2 and CNOT3 C-terminal (-C) regions.
Andreas Boland, Ying Chen, Tobias Raisch, Stefanie Jonas, Duygu Kuzuoğlu-Öztürk, Lara Wohlbold, Oliver Weichenrieder, Elisa Izaurralde   +7 more
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The Ccr4-Not Complex: Architecture and Structural Insights

2017
The Ccr4-Not complex is an essential multi-subunit protein complex that plays a fundamental role in eukaryotic mRNA metabolism and has a multitude of different roles that impact eukaryotic gene expression . It has a conserved core of three Not proteins, the Ccr4 protein, and two Ccr4 associated factors, Caf1 and Caf40.
Collart, Martine, Panasenko, Olesya
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Discovery and SAR of Trisubstituted Thiazolidinones as CCR4 Antagonists.

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Shelley, Allen, Bradley, Newhouse, Aaron S, Anderson, Benjamin, Fauber, Andrew, Allen, David, Chantry, Christine, Eberhardt, Joshua, Odingo, Laurence E, Burgess   +8 more
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Optimization of 2-aminothiazole derivatives as CCR4 antagonists

Bioorganic & Medicinal Chemistry Letters, 2006
A series of 2-aminothiazole-derived antagonists of the CCR4 receptor has been synthesized and their affinity for the receptor evaluated using a [(125)I]TARC (CCL17) displacement assay. Optimization of these compounds for potency and pharmacokinetic properties led to the discovery of potent, orally bioavailable antagonists.
Xuemei, Wang, Feng, Xu, Qingge, Xu, Hossen, Mahmud, Jonathan, Houze, Liusheng, Zhu, Michelle, Akerman, George, Tonn, Liang, Tang, Brian E, McMaster, Daniel J, Dairaghi, Thomas J, Schall, Tassie L, Collins, Julio C, Medina   +13 more
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The importance of CCR4 and CCR6 in experimental autoimmune encephalomyelitis

Journal of Neuroimmunology, 2013
Chemokine receptors (CCRs) play important roles in the pathogenesis of immune-mediated diseases, as well as in normal immune response. We examined the role of CCR6 and CCR4 in experimental autoimmune encephalomyelitis (EAE) by using CCR6(-/-)CCR4(-/-) double knockout (DKO) and single knockout mice.
Kota, Moriguchi, Katsuichi, Miyamoto, Noriko, Tanaka, Osamu, Yoshie, Susumu, Kusunoki   +4 more
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CCR4 ANTAGONISTS IN SEPSIS

2000
CCR4 receptor antagonists are used for treatment and/or prevention of sepsis and/or septic shock. The antagonists of this invention typically are selected among several classes but preferably are anti-CCR4 antibodies.
APPLIED RESEARCH SYSTEMS, POWER CHRISTINE A, CHVATCHKO YOLANDE   +2 more
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