Results 201 to 210 of about 34,412 (225)

North American Adult T-Cell Leukemia/Lymphoma Has Frequent Mutations in CCR4 and Responds in Vitro to a Small Molecule CCR4 Antagonist, CCR4-351

Blood, 2023
Adult T-cell leukemia/lymphoma (ATLL) is a rare and aggressive disease of malignant CD4+ T cells that develops in human T-lymphotropic virus-1 (HTLV-1) carriers. Patients diagnosed with ATLL have the worst survival among all peripheral T-cell lymphomas.
B. Hilda Ye, Eric Liu, Kith Pradhan, Erik Guillen, Urvi A Shah, Aditi Shastri, Gregoire Lauvau, Murali Janakiram, Alejandro Sica, Paul D. Kassner, Amit Verma   +10 more
openaire   +1 more source

Novel interaction between CCR4 and CAF1 in rice CCR4–NOT deadenylase complex

Plant Molecular Biology, 2016
Rice is an important crop in the world. However, little is known about rice mRNA deadenylation, which is an important regulation step of gene expression at the post-transcriptional level. The CCR4-NOT1 complex contains two key components, CCR4 and CAF1, which are the main cytoplasmic deadenylases in eukaryotic cells.
Wei-Lun, Chou, Yue-Lin, Chung, Jhen-Cheng, Fang, Chung-An, Lu   +3 more
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Identification of chemokine receptor CCR4 antagonist

Bioorganic & Medicinal Chemistry Letters, 2005
The present study reports the identification and hits to leads optimization of chemokine receptor CCR4 antagonists. Compound 12 is a high affinity, non-cytotoxic antagonist of CCR4 that blocks the functional activity mediated by the receptor.
Ashok V, Purandare, Aiming, Gao, Honghe, Wan, John, Somerville, Christine, Burke, Carrie, Seachord, Wayne, Vaccaro, John, Wityak, Michael A, Poss   +8 more
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Antagonists of CCR4 as Immunomodulatory Agents

Current Topics in Medicinal Chemistry, 2006
The chemokine receptor CCR4 is broadly expressed on cells of the immune system. It is known to play a central role in T cell migration to the thymus, and T cell maturation and education. In addition, CCR4 is known to modulate T cell migration to several sites of inflammation in the body, including the skin, and lungs.
Ashok V, Purandare, John E, Somerville
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Optimization of CCR4 Antagonists: Side‐Chain Exploration.

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ashok V, Purandare, Honghe, Wan, Aiming, Gao, John, Somerville, Christine, Burke, Wayne, Vaccaro, Xiaoxia, Yang, Kim W, McIntyre, Michael A, Poss   +8 more
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Internalization of CCR4 and Inhibition of Chemotaxis by K777, a Potent and Selective CCR4 Antagonist

Pharmacology, 2013
CC chemokine receptor 4 (CCR4) is a G protein-coupled receptor that regulates the chemotaxis of Th2 lymphocytes, which are key players in allergic diseases. K777 is a small compound identified in a binding assay using a CCR4 ligand, CCL17. K777 inhibited both CCL17 binding and CCL17-induced chemotaxis in Hut78 cells (IC₅₀: 57 and
Takashi, Sato, Miho, Iwase, Motoki, Miyama, Masato, Komai, Etsuo, Ohshima, Akira, Asai, Hiroshi, Yano, Ichiro, Miki   +7 more
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CCR4 Expression in Hodgkin Lymphoma

Blood, 2011
Abstract Abstract 2626 In Hodgkin lymphoma (HL) a minority (<1%) of tumor cells is found in a reactive background. The tumor cells shape their environment by the production of several chemokines and cytokines. Production of the chemokine TARC will lead to the attraction of Th2 and Treg cells specifically to involved ...
Lydia Visser, Myrna van West, Bea Rutgers, Sibrand Poppema, Anke Van Den Berg   +4 more
openaire   +1 more source

Optimization of 2-aminothiazole derivatives as CCR4 antagonists

Bioorganic & Medicinal Chemistry Letters, 2006
A series of 2-aminothiazole-derived antagonists of the CCR4 receptor has been synthesized and their affinity for the receptor evaluated using a [(125)I]TARC (CCL17) displacement assay. Optimization of these compounds for potency and pharmacokinetic properties led to the discovery of potent, orally bioavailable antagonists.
Xuemei, Wang, Feng, Xu, Qingge, Xu, Hossen, Mahmud, Jonathan, Houze, Liusheng, Zhu, Michelle, Akerman, George, Tonn, Liang, Tang, Brian E, McMaster, Daniel J, Dairaghi, Thomas J, Schall, Tassie L, Collins, Julio C, Medina   +13 more
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Clinical Application of Anti-CCR4 Monoclonal Antibody

Oncology, 2015
Mogamulizumab (KW-0761) is a humanized anti-CCR4 monoclonal antibody with a defucosylated Fc region (Potelligent® Technology), which markedly enhances antibody-dependent cellular cytotoxicity by increasing its binding affinity to the Fc&#947; receptor expressed on effector cells. It is an effective agent for patients with CCR4-positive adult T-cell
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Increased CCR4 expression in active systemic lupus erythematosus

Journal of Leukocyte Biology, 2001
AbstractCC chemokine receptor (CCR)4 is selectively expressed on Th2-type Tcells and has been shown to be responsible for Th2-dominant immuneresponses. In this study, we analyzed the expression of CCR4 in activesystemic lupus erythematosus (SLE) patients by FACS analysis usinganti-human CCR4 monoclonal antibody and determined the clinicalrelevance in ...
K, Hase, K, Tani, T, Shimizu, Y, Ohmoto, K, Matsushima, S, Sone   +5 more
openaire   +2 more sources