Results 101 to 110 of about 82,628 (226)

Immune involvement in neuropsychiatric disorders: Insights from single‐cell transcriptomic studies

Psychiatry and Clinical Neurosciences, EarlyView.
Neuropsychiatric disorders pose profound challenges to both research and treatment, largely due to their clinical heterogeneity and the limited understanding of their underlying biological mechanisms. While bulk RNA sequencing (bulk RNA‐seq) has been widely used to study gene expression, it cannot resolve cell‐type‐specific signals or detect rare ...
Tsutomu Takeda, Michihiro Toritsuka, Hiroto Tamakoshi, Nakao Iwata, Manabu Makinodan   +4 more
wiley   +1 more source

Carrying SNP rs17506395 (T > G) in TP63 gene and CCR5Δ32 mutation associated with the occurrence of breast cancer in Burkina Faso

Open Life Sciences
Genetic alterations in the TP63 (GenBank: NC_000003.12, ID: 8626) and CCR5 (receptor 5 chemokine co-receptor) (GenBank: NC_000003.12, ID: 1234) genes may increase the risk of developing breast cancer. The aim of this study was to investigate the probable
Traoré Lassina, Savadogo Mousso, Zouré Abdou Azaque, Kiendrebeogo Touwendpoulimdé Isabelle, Soudre Fabienne Marie B. T. B., Dabre Soayebo, Traore Aida Djé Djénéba, Adico Marc Donald Wilfried, Lare Tilate, Ouedraogo Teega-Wendé Clarisse, Ouedraogo Rogomenoma Alice, Ouattara Abdoul Karim, Yelemkoure Edwige T., Sawadogo Alexis Yobi, Zongo Nayi, Bambara Hierrhum Aboubacar, Nadembega Christelle W., Djigma Florencia W., Simpore Jacques   +18 more
doaj   +1 more source

Modulation of CCR5 expression and R5 HIV-1 infection in primary macrophages exposed to sera from HESN, LTNP, and chronically HIV-1 infected people with or without natural antibodies to CCR5

Virus Research
CCR5 is the main co-receptor for HIV-1 cell entry and it plays key roles in HIV-1 mucosal transmission. Natural anti-CCR5 antibodies were found in HIV-1-exposed seronegative and long-term non-progressor subjects, suggesting a role in controlling viral ...
Iole Farina, Mauro Andreotti, Claudia Pastori, Roberta Bona, Clementina Maria Galluzzo, Roberta Amici, Cristina Purificato, Caterina Uberti-Foppa, Agostino Riva, Maria Cristina Gauzzi, Lucia Lopalco, Laura Fantuzzi   +11 more
doaj   +1 more source

Etiology, pathogenesis and treatment of peri‐implantitis: A European perspective

Periodontology 2000, EarlyView.
Abstract Peri‐implantitis is a plaque‐associated pathological condition occurring in tissues around dental implants. It is characterized by inflammation in the peri‐implant mucosa and progressive loss of supporting bone. Over the last 30 years, peri‐implantitis has become a major disease burden in dentistry.
Tord Berglundh, Andrea Mombelli, Frank Schwarz, Jan Derks   +3 more
wiley   +1 more source

The frequency of CCR5 promoter polymorphisms and CCR5 32 mutation in Iranian populations [PDF]

Iranian Journal of Basic Medical Sciences, 2015
Evidence showed that chemokines serve as pro-migratory factors for immune cells. CCL3, CCL4 and CCL5, as the main CC  chemokines subfamily members, activate immune cells through binding to CC chemokine receptor 5 or CCR5.
Mohammad Zare-Bidaki, Masoud Karimi-Googheri, Gholamhossein Hassanshahi, Nahid Zainodini, Mohammad Kazemi Arababadi   +4 more
doaj  

CCR5: Window of Biocapitalism [PDF]

Cell, 2015
The author of the Genealogy of a Gene, Myles W. Jackson, uses the gene CCR5 as a window framing a vista of biocapitalism. With many compartmentalized panes, this window looks at different edges of its scene as the author retells the scientific and pharmaceutical history of CCR5, discusses the world of intellectual property, and ends with thought ...
openaire   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

Evaluation of CCR5Δ32 Polymorphism in Patients with Systemic Lupus Erythematosus and Healthy Individuals

Medical Laboratory Journal, 2018
Background and Objectives: C-C chemokine receptor type 5 (CCR5) is a chemokine receptor expressed at high levels on the surface of T-cells. A 32-bp deletion in the coding region of the CCR5 (CCR5Δ32) leads to production of an incomplete protein that is ...
Zahra Heydarifard, Alijan Tabarraei, Nafiseh Abdollahi, Abdolvahab Moradi, Yosef Khanjari   +4 more
doaj  

Monocyte Chemotactic Factors in the Airways of Patients With Mild Asthma Before and After an Allergen Challenge

Allergy, EarlyView.
Nami Shrestha Palikhe, Yingqi Wu, Karen J. Howie, Caitlin Stevens, Jennifer Mitchell, Lesley Wiltshire, Gail M. Gauvreau, Harissios Vliagoftis   +7 more
wiley   +1 more source

Distribution and prognostic value of T‐cells in primary colorectal cancer and adjacent non‐tumor mucosa in stage IV versus stage I–III patients

International Journal of Cancer, Volume 158, Issue 10, Page 2760-2770, 15 May 2026.
What's New? While colonic mucosa lymphocytes have been quantified in the context of inflammatory diseases, T‐cells in non‐tumor mucosa adjacent to colorectal cancer remain understudied. This study found that in stage IV colorectal cancer (synchronous liver metastasis), higher Foxp3+ T‐cell density and Foxp3+/CD4+ and Foxp3+/CD8+ T‐cell ratios in non ...
Esraa Ali, Wenjing Ye, Sergii Pavlov, Lenka Červenková, Filip Ambrozkiewicz, Ondřej Vyčítal, Petr Hošek, Ondřej Daum, Václav Liška, Kari Hemminki, Andriy Trailin   +10 more
wiley   +1 more source