Results 111 to 120 of about 90,382 (271)

CCR5: Window of Biocapitalism [PDF]

Cell, 2015
The author of the Genealogy of a Gene, Myles W. Jackson, uses the gene CCR5 as a window framing a vista of biocapitalism. With many compartmentalized panes, this window looks at different edges of its scene as the author retells the scientific and pharmaceutical history of CCR5, discusses the world of intellectual property, and ends with thought ...
openaire   +1 more source

Immune non‐response despite effective antiretroviral therapy in people living with HIV: A review of potential mechanisms, biomarkers and therapeutic approaches

HIV Medicine, EarlyView.
Abstract Introduction A proportion of people living with HIV (PLWH) fail to restore their CD4 count or their CD4/CD8 ratio despite effective antiretroviral therapy (ART). PLWH with immune non‐response (INR) are at a higher risk of both AIDS and non‐AIDS events. The underlying mechanisms of INR remain unclear.
Charlotte Silvestre, Antoine Gross, Alain Makinson   +2 more
wiley   +1 more source

Carrying SNP rs17506395 (T > G) in TP63 gene and CCR5Δ32 mutation associated with the occurrence of breast cancer in Burkina Faso

Open Life Sciences
Genetic alterations in the TP63 (GenBank: NC_000003.12, ID: 8626) and CCR5 (receptor 5 chemokine co-receptor) (GenBank: NC_000003.12, ID: 1234) genes may increase the risk of developing breast cancer. The aim of this study was to investigate the probable
Traoré Lassina, Savadogo Mousso, Zouré Abdou Azaque, Kiendrebeogo Touwendpoulimdé Isabelle, Soudre Fabienne Marie B. T. B., Dabre Soayebo, Traore Aida Djé Djénéba, Adico Marc Donald Wilfried, Lare Tilate, Ouedraogo Teega-Wendé Clarisse, Ouedraogo Rogomenoma Alice, Ouattara Abdoul Karim, Yelemkoure Edwige T., Sawadogo Alexis Yobi, Zongo Nayi, Bambara Hierrhum Aboubacar, Nadembega Christelle W., Djigma Florencia W., Simpore Jacques   +18 more
doaj   +1 more source

The Role of Viruses in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the presence and potential pathogenic role of viruses in periodontitis. Design: Narrative Review; Population: Patients with periodontitis; Exposure: Detection of viruses in oral samples (biopsies, saliva, gingival crevicular fluid, subgingival plaque, blood); Outcome: Viral prevalence, load ...
Kim Natalie Stolte, Jørgen Slots, Henrik Dommisch   +2 more
wiley   +1 more source

Infection of Fetal Human Astrocytes by M-Tropic HIV Is Not Inhibited by Prostaglandin-Mediated CCR5 Downregulation [PDF]

, 1999
Nahed Abdel‐Haq, Hsiao‐Nan Hao, William D. Lyman   +2 more
openalex   +1 more source

The frequency of CCR5 promoter polymorphisms and CCR5 Δ 32 mutation in Iranian populations.

Iranian journal of basic medical sciences, 2015
Evidence showed that chemokines serve as pro-migratory factors for immune cells. CCL3, CCL4 and CCL5, as the main CC chemokines subfamily members, activate immune cells through binding to CC chemokine receptor 5 or CCR5. Macrophages, NK cells and T lymphocytes express CCR5 and thus, affected CCR5 expression or functions could be associated with altered
Zare-Bidaki, Mohammad, Karimi-Googheri, Masoud, Hassanshahi, Gholamhossein, Zainodini, Nahid, Kazemi Arababadi, Mohammad   +4 more
openaire   +3 more sources

Immune involvement in neuropsychiatric disorders: Insights from single‐cell transcriptomic studies

Psychiatry and Clinical Neurosciences, EarlyView.
Neuropsychiatric disorders pose profound challenges to both research and treatment, largely due to their clinical heterogeneity and the limited understanding of their underlying biological mechanisms. While bulk RNA sequencing (bulk RNA‐seq) has been widely used to study gene expression, it cannot resolve cell‐type‐specific signals or detect rare ...
Tsutomu Takeda, Michihiro Toritsuka, Hiroto Tamakoshi, Nakao Iwata, Manabu Makinodan   +4 more
wiley   +1 more source

Evaluation of CCR5Δ32 Polymorphism in Patients with Systemic Lupus Erythematosus and Healthy Individuals

Medical Laboratory Journal, 2018
Background and Objectives: C-C chemokine receptor type 5 (CCR5) is a chemokine receptor expressed at high levels on the surface of T-cells. A 32-bp deletion in the coding region of the CCR5 (CCR5Δ32) leads to production of an incomplete protein that is ...
Zahra Heydarifard, Alijan Tabarraei, Nafiseh Abdollahi, Abdolvahab Moradi, Yosef Khanjari   +4 more
doaj  

565. CCR5-Uco-TALEN – A Novel Transcription Activator-Like Effector Nuclease That Mediates High-Efficiency Knockout of HIV Co-Receptor CCR5 in Primary T Cells After mRNA Transfection [PDF]

, 2015
Ulrike Mock, Rafał Machowicz, Ilona Hauber, Stefan Horn, Pierre Abramowski, Belinda Berdien, Joachim Hauber, Boris Fehse   +7 more
openalex   +1 more source

Etiology, pathogenesis and treatment of peri‐implantitis: A European perspective

Periodontology 2000, EarlyView.
Abstract Peri‐implantitis is a plaque‐associated pathological condition occurring in tissues around dental implants. It is characterized by inflammation in the peri‐implant mucosa and progressive loss of supporting bone. Over the last 30 years, peri‐implantitis has become a major disease burden in dentistry.
Tord Berglundh, Andrea Mombelli, Frank Schwarz, Jan Derks   +3 more
wiley   +1 more source