Results 131 to 140 of about 90,382 (271)

Deciphering the Transcriptomic Signatures of Aging Across Organs in Mice

Aging Cell, Volume 25, Issue 2, February 2026.
Comprehensive transcriptomic profiling of eight mouse organs across six ages reveals how aging reshapes biological processes. Trajectory and network analyses distinguish shared and organ‐specific signatures, charting the molecular landscape of systemic aging.
Sarah Morsy, Enzo Scifo, Kan Xie, Kristina Schaaf, Jenny Russ, Stefan Paulusch, Elena De Domenico, Paolo Salomoni, Daniele Bano, Dan Ehninger   +9 more
wiley   +1 more source

663. Protecting the CNS from Inflammation and Excitotoxic Neuron Loss by Prior Intra Marrow Injection of a rSV40-Derived Vector Carrying an Interfering RNA Against CCR5 [PDF]

, 2008

openalex   +1 more source

Supplementary Figures 1-10 from Maximal T Cell–Mediated Antitumor Responses Rely upon CCR5 Expression in Both CD4⁺ and CD8⁺ T Cells

, 2023
Alicia González-Martín, Lucio Gómez, Joseph Lustgarten, E. Mira, Santos Mañes   +4 more
openalex   +1 more source

Hevin Promotes Aging‐Related Cardiac Dysfunction via Facilitating Cardiac Inflammation in Male Mice

Aging Cell, Volume 25, Issue 2, February 2026.
Hevin released by iWAT into circulation stimulates cardiac macrophages through TLR4, inducing their polarization and CCL5 secretion, leading to worsened cardiac dysfunction and subsequent recruitment of additional inflammatory cells for pro‐inflammatory factor release.
Shi‐Yu Huang, Yu‐Jie Chen, Yu‐Xin Hu, Jia‐Chen Liu, Min Hu   +4 more
wiley   +1 more source

Host factors and early treatments to restrict paediatric HIV infection and early disease progression [PDF]

, 2015
open6noA body of evidence indicates that a threshold level of the virus is required to establish systemic and persistent HIV infection in the host and that this level depends on virus-host interactions.
De Rossi, Anita, Freguja, Riccardo, Gianesin, Ketty, Giaquinto, Carlo, Petrara, Raffaella, Zanchetta, Marisa   +5 more
core   +1 more source

Tumor Microenvironments in Malignant Ovarian Germ Cell Tumors: MHC Class I Loss and T‐Cell Exhaustion in Dysgerminoma

Cancer Science, Volume 117, Issue 2, Page 566-575, February 2026.
Malignant ovarian germ cell tumor subtypes exhibit distinct tumor microenvironments. Dysgerminomas harbor abundant nonexhausted T cells, with progenitor exhausted T cells present in 60% of PD‐1–positive cases. However, MHC class I expression is lost across all analyzed subtypes, suggesting that restoring class I expression in dysgerminomas may enhance ...
Miya Nakashima, Takeshi Iwasaki, Yoshihiro Katayama, Masatoshi Shimo, Ken Takigawa, Naomi Shimada, Michiko Matsushita, Satoshi Kuwamoto, Shinya Sato, Masato Toya, Kohta Miyawaki, Koichi Akashi, Kiyoko Kato, Yoshinao Oda   +13 more
wiley   +1 more source

CRISPR in HIV: Dangers of CCR5 Deletion

, 2020
Stefano Rusconi, Andrea Giacomelli
openalex   +2 more sources

МУТАЦІЯ ГЕНУ CCR5: ОСОБЛИВОСТІ ПРОЦЕСУ ШТУЧНОГО МУТАГЕНЕЗУ

, 2022
Сергій Прилуцький
openalex   +2 more sources

Unveiling the Crucial Nexus: Mitochondrial Quality Control as a Central Driver in Metabolic Dysfunction‐Associated Steatotic Liver Disease Pathogenesis

Cell Proliferation, Volume 59, Issue 2, February 2026.
Mitochondrial quality control (MQC) impairment plays a central role in driving the pathogenesis of metabolism‐associated steatotic liver disease (MASLD). Specifically, this is manifested as reduced mitophagy; increased mitochondrial fission and decreased fusion; and impaired mitochondrial biogenesis.
Wenkai Fu, Junqi Wang, Nan Lu, Zhijiang Guo, Sang‐Bing Ong, Yong Gao, Hao Zhou, Xing Chang, Miao Meng   +8 more
wiley   +1 more source

CD4 and CCR5 Constitutively Interact at the Plasma Membrane of Living Cells [PDF]

, 2006
Gérald Gaibelet, Thierry Planchenault, Serge Mazères, Fabrice Dumas, Fernando Arenzana‐Seisdedos, André Lopez, Bernard Lagane, Françoise Bachelerie   +7 more
openalex   +1 more source