Results 131 to 140 of about 87,303 (273)

Evaluation of CCR5Δ32 Polymorphism in Patients with Systemic Lupus Erythematosus and Healthy Individuals

Medical Laboratory Journal, 2018
Background and Objectives: C-C chemokine receptor type 5 (CCR5) is a chemokine receptor expressed at high levels on the surface of T-cells. A 32-bp deletion in the coding region of the CCR5 (CCR5Δ32) leads to production of an incomplete protein that is ...
Zahra Heydarifard, Alijan Tabarraei, Nafiseh Abdollahi, Abdolvahab Moradi, Yosef Khanjari   +4 more
doaj  

Mice transgenic for human CD4 and CCR5 are susceptible to HIV infection [PDF]

, 1997
Jessie Browning, James W. Horner, Massimo Pettoello‐Mantovani, Christina Raker, Sergey Yurasov, Ronald A. DePinho, Harris Goldstein   +6 more
openalex   +1 more source

Autoimmunity in MASLD: Focus on autoantibodies, anti‐apolipoprotein A1 IgG and G protein‐coupled receptors

European Journal of Clinical Investigation, EarlyView.
This review outlines the potential role of anti‐GPCR autoantibodies in MASLD/MASH, given their involvement in a wide range of diseases and their possible contribution to MASLD/MASH pathophysiology. We also focused on anti‐ApoA1 autoantibodies, sharing functional features with anti‐GPCR autoantibodies and have been shown to promote liver steatosis in ...
Sabrina Pagano, Emmanuel Somm, François R. Jornayvaz, Nicolas Vuilleumier   +3 more
wiley   +1 more source

Interaction of Chemokine Receptor CCR5 with its Ligands: Multiple Domains for HIV-1 gp120 Binding and a Single Domain for Chemokine Binding [PDF]

, 1997
Lijun Wu, Greg LaRosa, Nasim Kassam, Cynthia J. Gordon, Heidi Heath, Nancy Ruffing, Howard Chen, Jason Humblias, Michel Samson, Marc Parmentier, John P. Moore, Charles R. Mackay   +11 more
openalex   +1 more source

The Fate of Gene Patents Under the New Utility Guidelines [PDF]

, 2001
The United States Patent and Trademark Office (PTO) recently finalized its patent utility guidelines. Promulgated by the PTO, the new guidelines will be used by patent examiners in determining whether a claimed invention should be awarded patent ...
Franzén, Johanna, Lundberg, Ida
core   +1 more source

Tertiary Lymphoid Structures Predict Prognosis and Immune Checkpoint Inhibitor Efficacy in Lung Squamous Cell Carcinoma

Immunology, EarlyView.
This study demonstrates that the presence, high density and maturity of TLSs in LUSC patients are strongly associated with significantly improved overall survival. TLS+ was an independent positive prognostic factor and predicted better outcomes even for patients receiving immunotherapy.
Kuifei Chen, Suna Zhou, Pin Zhou, Zhenwei Sun, Yixiu Xu, Ziran Chen, Liangmin Zhang, Wenhu Pi, Meifu Gan, Haihua Yang   +9 more
wiley   +1 more source

CCR5 Disruption in Induced Pluripotent Stem Cells Using CRISPR/Cas9 Provides Selective Resistance of Immune Cells to CCR5-tropic HIV-1 Virus

Molecular Therapy: Nucleic Acids, 2015
The chemokine (C-C motif) receptor 5 (CCR5) serves as an HIV-1 co-receptor and is essential for cell infection with CCR5-tropic viruses. Loss of functional receptor protects against HIV infection.
HyunJun Kang, Petra Minder, Mi Ae Park, Walatta-Tseyon Mesquitta, Bruce E Torbett, Igor I Slukvin   +5 more
doaj   +1 more source

Hepatic Inflammation and Liver Injury in a Model of Bacterial Infection Triggered Acute‐on‐Chronic Liver Injury

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background and Aim Acute‐on‐chronic liver failure (ACLF) is characterized by acute decompensation of chronic liver disease in the presence of an acute trigger, and bacterial infection (BI) is the most common trigger of ACLF. Therefore, we aimed to establish a mouse model that mimics bacterial infection‐related acute‐on‐chronic liver failure ...
S. C. Karatayli, S. N. Weber, R. A. Hall, M. Hohl, L. Kaps, J. M. Schattenberg, F. Lammert, E. Karatayli   +7 more
wiley   +1 more source

Microglia Express CCR5, CXCR4, and CCR3, but of These, CCR5 Is the Principal Coreceptor for Human Immunodeficiency Virus Type 1 Dementia Isolates [PDF]

, 1999
Andrew Albright, Joseph T.C. Shieh, Takayuki Itoh, Benhur Lee, David Pleasure, Michael J. O’Connor, Robert W. Doms, Francisco González‐Scarano   +7 more
openalex   +1 more source

Etiology, pathogenesis and treatment of peri‐implantitis: A European perspective

Periodontology 2000, EarlyView.
Abstract Peri‐implantitis is a plaque‐associated pathological condition occurring in tissues around dental implants. It is characterized by inflammation in the peri‐implant mucosa and progressive loss of supporting bone. Over the last 30 years, peri‐implantitis has become a major disease burden in dentistry.
Tord Berglundh, Andrea Mombelli, Frank Schwarz, Jan Derks   +3 more
wiley   +1 more source