Results 1 to 10 of about 7,732 (197)

Increased CD112 expression in methylcholanthrene-induced tumors in CD155-deficient mice. [PDF]

PLoS ONE, 2014
Tumor recognition by immune effector cells is mediated by antigen receptors and a variety of adhesion and costimulatory molecules. The evidence accumulated since the identification of CD155 and CD112 as ligands for DNAM-1 in humans and mice has suggested
Yoko Nagumo, Akiko Iguchi-Manaka, Yumi Yamashita-Kanemaru, Fumie Abe, Günter Bernhardt, Akira Shibuya, Kazuko Shibuya   +6 more
doaj   +5 more sources

CD155-based chimeric antigen receptor T cells: a promising immunotherapy for cervical and breast cancer [PDF]

Frontiers in Immunology
IntroductionAs an immune checkpoint molecule that is overexpressed in cervical and breast cancer, CD155 represents an attractive target for chimeric antigen receptor (CAR) T-cell therapy.
Jun Ma, Jun Ma, Jun Ma, Wenjing Zhu, Wenjing Zhu, Rui Zhao, Rui Zhao, Qianqian Shi, Qianqian Shi, Qianqian Shi, Fang Yang, Fang Yang, Fang Yang, Yangnan Ding, Yangnan Ding, Yangnan Ding, Enwu Yuan, Enwu Yuan, Enwu Yuan, Enwu Yuan, Kai Zhang, Kai Zhang, Kai Zhang, Xin Zhao, Xin Zhao   +24 more
doaj   +2 more sources

Dual targeting of CD155 augments the antitumor efficacy of ROR1-CAR-T cells in ovarian cancer [PDF]

Cancer Immunology, Immunotherapy
Background Exploring novel therapeutic targets and developing targeted therapies constitute an urgent clinical need for improving the prognosis of ovarian cancer (OC), particularly among patients with advanced stages. Currently, chimeric antigen receptor
Yingjun Ye, Tingwei Liu, Chao Cheng, Huajing Wang, Jiacheng Shen, Xiaowen He, Shaohua Xu   +6 more
doaj   +2 more sources

HSP47 inhibition-induced CD155 expression through TRAF2 deubiquitination promotes tumor immune evasion [PDF]

Journal for ImmunoTherapy of Cancer
Background Heat shock protein 47 (HSP47) is crucial for protein quality control and tumor progression. While its role in cancer biology is well established, its impact on cancer immunity remains poorly understood.
Liang Chen, Hao Zhou, Jiahao Zhang, Yucheng Xue, Wenkan Zhang, Zenan Wang, Hangxiang Sun, Binghao Li, Zhaoming Ye, Haochen Mou, Hao Qu, Shixin Chen, Zhuli Wang, Yinwang Eloy, Zhenxuan Shao, Fangqian Wang, Xupeng Chai, Minjun Yao, Shenzhi Zhao, Jiangchu Lei, Lingxiao Jin, Senxu Lu   +21 more
doaj   +2 more sources

Arecoline upregulates CD155 expression to facilitate immune evasion in oral squamous cell carcinoma [PDF]

Journal for ImmunoTherapy of Cancer
Background Areca nut is the fourth most addictive substance worldwide and is a known Group 1 carcinogen. Chronic areca nut chewing has been strongly associated with the development of oral squamous cell carcinoma (OSCC), although the underlying ...
Qian Wang, Ming Zhou, Bo Xiang, Wei Xiong, Pan Chen, Zhaoyang Zeng, Shanshan Zhang, Junshang Ge, Yi Meng, Yuhang Liu, Yian Wang, Zhaojian Gong   +11 more
doaj   +2 more sources

Targeting CD155 in lung adenocarcinoma: A5 nanobody-based therapeutics for precision treatment and enhanced drug delivery [PDF]

Signal Transduction and Targeted Therapy
This study presents a novel approach targeting CD155, an overexpressed protein in lung adenocarcinoma (LUAD), using nanobodies with exceptional precision and efficacy.
Kyunghee Noh, Soyeon Yi, Hyeran Kim, Jieun Lee, Suhyeon Kim, Wonbeak Yoo, Eunkyeong Jung, Jinsol Choi, Hwangseo Park, Seungha Hwang, Jin Young Kang, Kwang-Hyun Park, Heewon Park, Yong-kyu Lee, Eun-Kyung Lim, Taejoon Kang, Juyeon Jung   +16 more
doaj   +2 more sources

CD155 as a therapeutic target in alveolar echinococcosis: insights from an Echinococcus multilocularis infection mouse model [PDF]

Frontiers in Microbiology
IntroductionAlveolar echinococcosis (AE) is a life-threatening zoonotic parasitic disease caused by the metacestode stage of Echinococcus multilocularis, characterized by granulomatous lesions and liver fibrosis. Immune exhaustion is the key mechanism by
Xue Zhang, Liang Li, Tao Sun, Ning Yang, Hui Liu, Jin Chu, Junlong Xue, Guodong Lü, Tuerganaili Aji, Xiaojuan Bi, Renyong Lin, Renyong Lin   +11 more
doaj   +2 more sources

Pan-cancer analysis identifies CD155 as a promising target for CAR-T cell therapy [PDF]

Genome Medicine
Background Chimeric antigen receptor T (CAR-T) cell therapy has shown remarkable success in treating hematologic malignancies. However, its efficacy against solid tumors remains limited. One of the major challenges is the lack of specific tumor antigens.
Xiaohong Liu, Yue Sun, Boxu Lin, Hao Xiong, Xinyue Lu, Binghe Tan, Chenglin Zhang, Mingyao Liu, Juliang Qin, Na Zhang, Bing Du   +10 more
doaj   +2 more sources

Prognostic and Predictive Significance of B7-H3 and CD155 Expression in Gastric Cancer Patients [PDF]

Diagnostics
Background/Objectives: This study aimed to characterize the expression patterns of B7 homolog 3 (B7-H3) and cluster of differentiation 155 (CD155), two immune-related transmembrane glycoproteins, in resectable gastric adenocarcinoma and to elucidate ...
Ozlem Dalda, Zehra Bozdag, Sami Akbulut, Hasan Gokce, Yasin Dalda, Ayse Nur Akatli, Mustafa Huz   +6 more
doaj   +2 more sources

CD155 blockade enhances allogeneic natural killer cell-mediated antitumor response against osteosarcoma [PDF]

Journal for ImmunoTherapy of Cancer
Background Allogeneic bone marrow transplant (alloBMT) is curative for hematologic malignancies through the graft-versus-tumor (GVT) effect but has been ineffective for solid tumors like osteosarcoma (OS). OS expresses CD155 which interacts strongly with
Lei Shi, Christian M Capitini, Amy K Erbe, Fernanda Szewc, Longzhen Song, Matthew H Forsberg, David P Turicek, Paul D Bates, Devin M Burpee, Aicha E Quamine, Johnathan D Ebben, Jillian M Kline, Emily O Lafeber, Madison F Phillips, Monica M Cho, Amanda S Ceas, John A Kink   +16 more
doaj   +2 more sources