Results 11 to 20 of about 7,732 (197)

CD155 promotes the progression of colorectal cancer by restraining CD8+ T cells via the PI3K/AKT/NF-κB pathway [PDF]

Cancer Immunology, Immunotherapy
Background CD155 is a crucial factor in the regulation of T cell function and contributes to immune escape. CD155 upregulation has been found in several types of cancer.
Rongpu Liang, Liting Liu, Dongbing Ding, Yiquan Li, Jiannan Ren, Bo Wei   +5 more
doaj   +2 more sources

Troxerutin suppresses the stemness of osteosarcoma via the CD155/SRC/β-catenin signaling axis [PDF]

Cellular & Molecular Biology Letters
Background Osteosarcoma is the most prevalent primary malignant bone tumor affecting pediatric and adolescent individuals. However, despite the passage of three decades, there has been no notable enhancement in the overall survival rate of patients with ...
Junkai Chen, Hongbo Li, Qinglin Jin, Xiaoguang Li, Yiwen Zhang, Jingnan Shen, Gang Huang, Junqiang Yin, Changye Zou, Xinyu Li, Xin He, Xianbiao Xie, Tiao Lin   +12 more
doaj   +2 more sources

Potential Roles of Serum Exosomal CD155 and its Impact on NK Cell Immunosuppression in Hepatocellular Carcinoma [PDF]

Balkan Medical Journal
Background: Targeted therapies directed at tumor immune checkpoint, like programmed death-ligand (PD-L)1/programmed death (PD)-1, have shown remarkable progress.
Wenzheng Han, Jinrong Lv, Mintuo Wang, Xiaoxin Wu, Dongdong Sun, Wenwen Chen, Yingying Wang, Wenjie Zhou, Yuxuan Yang, Jia Bao, Qingzhen Han, Xiaopeng Chen, Fei Guo, Gang Feng, Min Li, Qing Chen   +15 more
doaj   +2 more sources

CD155 as a prognostic and predictive biomarker in acute myeloid leukemia [PDF]

Discover Oncology
Background Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy with different molecular and genetic alterations. CD155 is expressed on myeloid cells and serves as a recognition molecule for natural killer (NK) cells to induce ...
Ashraf Zeidan Abdalla, Salah Mabrouk Khallaf, Asmaa Mohammed Zahran, Nehal Adel Rayan, Ahmed Refaat Abd Elzaher   +4 more
doaj   +2 more sources

CAR-T cells targeting CD155 reduce tumor burden in preclinical models of leukemia and solid tumors [PDF]

The Journal of Clinical Investigation
CAR-T cells are a powerful yet expensive tool in cancer immunotherapy. Although their use in targeting hematological malignancies is well established, using a single CAR-T cell therapy to treat both hematological and solid tumors, which can reduce cost ...
Tianchen Xiong, Ge Wang, Peng Yu, Zhenlong Li, Debao Li, Jianying Zhang, Song Lu, Ruiqi Yang, Xiaolong Lian, Jianhong Mi, Rui Ma, Zhiyao Li, Guido Marcucci, Tingting Zhao, Michael A. Caligiuri, Jianhua Yu   +15 more
doaj   +2 more sources

NECTIN4 regulates the cell surface expression of CD155 in non-small cell lung cancer cells and induces tumor resistance to PD-1 inhibitors [PDF]

Cancer Immunology, Immunotherapy
The development of immune checkpoint inhibitors has changed treatment strategies for some patients with non-small cell lung cancer (NSCLC). However, resistance remains a major problem, requiring the elucidation of resistance mechanisms, which might aid ...
Shun Mizusaki, Yasuto Yoneshima, Eiji Iwama, Tadayuki Nakashima, Ritsu Ibusuki, Daisuke Shibahara, Kohei Otsubo, Kentaro Tanaka, Isamu Okamoto   +8 more
doaj   +2 more sources

CD155

, 2022
Esophageal cancer is the sixth leading cause of death (4%) among all tumors in males, China has the largest number of esophageal cancer patients in the world, with about 193,000 deaths per year, 90% of which are esophageal squamous cell cancer (ESCA).
  +4 more sources

Tumor-associated macrophage-specific CD155 contributes to M2-phenotype transition, immunosuppression, and tumor progression in colorectal cancer

Journal for ImmunoTherapy of Cancer, 2022
Background Onco-immunogenic molecule CD155 is overexpressed in various tumor microenvironments (TME) including in colorectal cancer (CRC). Tumor-associated macrophages (TAMs) are the most abundant immune cells in CRC TME and play a vital role in CRC ...
Yong Huang, Xudong Zhu, Bo Wei, Rongpu Liang, Tianyun Lan, Dongbing Ding, Shengxin Huang, Jun Shao, Zongheng Zheng, Tufeng Chen, Jianpei Liu, Janak L Pathak, Hongbo Wei   +12 more
doaj   +1 more source

CD155 Promotes the Progression of Cervical Cancer Cells Through AKT/mTOR and NF-κB Pathways

Frontiers in Oncology, 2021
Expression of the immunoglobulin superfamily member CD155 was increased in a variety of human malignancies, but the role of CD155 in tumorigenesis and tumor development in cervical cancer has not been elucidated.
Lu Liu, Lu Liu, Lu Liu, Ying Wang, Chen Geng, Chen Geng, Chen Geng, Aihong Wang, Sai Han, Sai Han, Sai Han, Xuewu You, Xuewu You, Xuewu You, Yu Sun, Yu Sun, Yu Sun, Junhua Zhang, Junhua Zhang, Junhua Zhang, Wei Lu, Wei Lu, Wei Lu, Youzhong Zhang, Youzhong Zhang, Youzhong Zhang   +25 more
doaj   +1 more source

Immunohistochemical analysis of CD155 expression in triple-negative breast cancer patients.

PLoS ONE, 2021
IntroductionCD155 is an immune checkpoint protein. Its overexpression is an indicator of poor prognosis in some types of cancer. However, the significance of CD155 expression in patients with triple-negative breast cancer, and the relationship between ...
Katsuhiro Yoshikawa, Mitsuaki Ishida, Hirotsugu Yanai, Koji Tsuta, Mitsugu Sekimoto, Tomoharu Sugie   +5 more
doaj   +1 more source