Results 71 to 80 of about 14,609 (214)

Evaluation of the diagnostic potential of CD1a immunohistochemistry for visceral leishmaniasis [PDF]

Revista do Instituto de Medicina Tropical de São Paulo, 2019
Visceral Leishmaniasis is a public health problem caused by protozoans of the genus Leishmania. K39 serological test is commonly used in the initial investigation, with high specificity, but variable sensitivity. Amastigotes can be identified by optical microscopy, however, the differential diagnosis with cellular debris or other intracellular ...
Gadelha, Sami de Andrade Cordeiro, Cunha, Maria do Perpétuo Socorro Saldanha da, Coelho, Gabriela Maia, Marinho, Tamises Melo Siqueira, Hirth, Carlos Gustavo   +4 more
openaire   +5 more sources

A Comparative Study of Clinicopathological and Immunohistochemical Expression of CD1a, RANK and RANKL in Langerhans Cell Histiocytosis of Jaw and Skull Lesions

Journal of Baghdad College of Dentistry, 2016
Background: Langerhans' cell histiocytosis (LCH) is a group of conditions affecting the reticuloendothelial system. It includes Letterer-Siwe disease, Hand-Schuller-Christian disease and eosinophilic granuloma and most often presents in childhood ...
Alyaa K Mohammed, Bashar H Abdullah
doaj   +1 more source

Cutaneous Crystal‐Storing Histiocytosis With Marginal Zone Lymphoma. A Case Report With A Striking Clinical Presentation

Journal of Cutaneous Pathology, Volume 53, Issue 7, Page 576-580, July 2026.
ABSTRACT Cutaneous crystal‐storing histiocytosis (CSH) is an extremely rare histopathologic finding of histiocytes accumulating crystals of immunoglobulin or paraproteins, often associated with lymphoplasmacytic malignancies. It commonly presents in a wide age range of both female and male adults with a history of a lymphoproliferative disorder ...
Ashton Arlen, Brad S. Graham, Gregory A. Hosler, Marsha C. Kinney   +3 more
wiley   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Langerhans cells in odontogenic epithelia of odontogenic fibromas

, 2017
Background/Purpose: Langerhans cell (LC) is an antigen-presenting cell that is very important for T-cell-mediated immune reactions. Our previous studies have shown the presence of LCs in some odontogenic tumors and cysts.
Wu, Yang-Che;Wang, Yi-Ping;Chang, Julia Yu-Fong;Chen, Hsin-Ming;Sun, Andy;Chiang, Chun-Pin, 江俊斌;王逸平;張玉芳;孫安迪;陳信銘   +1 more
core   +1 more source

11‐year‐old girl presenting with blurred vision and progressive right arm weakness

Brain Pathology, EarlyView.
Trung Toan Tran, Thi My Hanh Luong, Bérengère Dadone‐Montaudié, Hong Nhung Ta, Thai Hoc Nguyen, Fanny Burel‐Vandenbos, Gia Du Pham   +6 more
wiley   +1 more source

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, Volume 13, Issue 35, 24 June 2026.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

Cytokine production by CD1a+ and CD1a−negative DC derived from septic patients.

, 2013
IL-10 (A) and IL-12p40 (B) levels were assayed in culture supernatants of CD1a+ and CD1a−negative DC purified at day 3 of monocyte differentiation and cultured an additional 48 h in the absence (0) or the presence of LPS (10 ng/ml) for maturation (LPS ...
Arnaud Alves (303754), Alain Haziot (303755), Dominique Charron (159655), Didier Payen (58727), Valérie Faivre (159641), Anne Claire Lukaszewicz (303753)   +5 more
core   +1 more source

CD-1a immunoexpression in oral lichen planus and oral lichenoid reaction

Caspian journal of dental research, 2020
Introduction: Oral lichen planus (OLP) is an immunologically mediated mucocutaneous diseases. Langerhans cells (LCs) are antigen presenting cells resident within oral mucosa which, together with intraepithelial lymphocytes, play a role in mucosal defense.
Azadeh Majidian, Maryam Seyedmajidi, Hamid Abbaszadeh, Majid Sharbatdaran, Sina Jafari, Hemmat Gholinia   +5 more
doaj  

New Role of P. brasiliensis α-Glucan: Differentiation of Non-conventional Dendritic Cells

Frontiers in Microbiology, 2019
The cell wall has a critical role in the host immune response to fungal pathogens. In this study, we investigated the influence of two cell wall fractions of the dimorphic fungi Paracoccidioides brasiliensis (Pb) in the in vitro generation of monocyte ...
Ana Camila Oliveira Souza, Cecília Favali, Naiara Caroline Soares, Natalia Machado Tavares, Márcio Sousa Jerônimo, Paulo Henrique Veloso Junior, Clara Luna Marina, Claire Santos, Cláudia Brodskyn, Anamelia Lorenzetti Bocca   +9 more
doaj   +1 more source