Results 1 to 10 of about 24,248 (145)

A novel anti-CD47 antibody with therapeutic potential for NK/T-cell lymphoma

Human Vaccines & Immunotherapeutics
NK/T-cell lymphoma (NKTCL) is a rare type of non-Hodgkin lymphoma (NHL). Although L-asparaginase-based chemotherapy has significantly improved survival in early-stage patients, the prognosis is poor in advanced and relapsed or refractory patients.
Liping Qin, Yajun Li, Ruolan Zeng, Yizi He, Xiaoyan Chen, Ling Xiao, Hui Zhou   +6 more
doaj   +2 more sources

CD47: an immunoregulatory nexus in liver and gastrointestinal disorders. [PDF]

eGastroenterology
Otuagomah J, Newcomb A, Gwag T, Wang S.
europepmc   +3 more sources

Immunotherapeutic Blockade of CD47 Increases Virus Neutralization Antibodies [PDF]

Vaccines
Background/Objectives: CD47 is a cell surface glycoprotein moderately expressed in healthy cells and upregulated in cancer and viral infected cells.
Lamin B. Cham, Thamer A. Hamdan, Hilal Bhat, Bello Sirajo, Murtaza Ali, Khaled Saeed Tabbara, Eman Farid, Mohamed-Ridha Barbouche, Tom Adomati   +8 more
doaj   +2 more sources

HCB101: a novel potent ligand-trap Fc-fusion protein targeting the CD47-SIRPα pathway with high safety and preclinical efficacy for hematological and solid tumors. [PDF]

J Hematol Oncol
Wang JT, Tseng CL, Teng HF, Kuo PH, Cheng YC, Chen YJ, Lu YH, Wang CC, Shen TK, Wang HF, Tsai PL, Wu YC, Ho CH, Sun WT, Li YC, Lee YH, Hung YJ, Chen M, Li Z, Juo ZS, Zhai W, Liu SS.   +21 more
europepmc   +3 more sources

CD47 cross-dressing by extracellular vesicles expressing CD47 inhibits phagocytosis without transmitting cell death signals

eLife, 2022
Transgenic CD47 overexpression is an encouraging approach to ameliorating xenograft rejection and alloresponses to pluripotent stem cells, and the efficacy correlates with the level of CD47 expression. However, CD47, upon ligation, also transmits signals
Yang Li, Yan Wu, Elena A Federzoni, Xiaodan Wang, Andre Dharmawan, Xiaoyi Hu, Hui Wang, Robert J Hawley, Sean Stevens, Megan Sykes, Yong-Guang Yang   +10 more
doaj   +1 more source

Human lung adenocarcinoma CD47 is upregulated by interferon-γ and promotes tumor metastasis

Molecular Therapy: Oncolytics, 2022
Tumor cells can evade attack by phagocytes by upregulating the self-marker CD47. The mechanisms underlying tumor CD47 upregulation, however, remain unclear.
Shuang Qu, Zichen Jiao, Geng Lu, Jiahan Xu, Bing Yao, Ting Wang, Jun Wang, Yongzhong Yao, Xin Yan, Tao Wang, Hongwei Liang, Ke Zen   +11 more
doaj   +1 more source

PYGO1 drives gastric cancer progression via the ITGB1/CD47 axis and is therapeutically targeted by pentagalloylglucose. [PDF]

J Transl Med
Jia Y, Li Y, Li Y, Li Y, Qu T, Fu Z, Ma Y, Li Z, Wang W, Yu M, Jin X, Gao X, Liu Y.   +12 more
europepmc   +3 more sources

EGFR‐Induced and c‐Src‐Mediated CD47 Phosphorylation Inhibits TRIM21‐Dependent Polyubiquitylation and Degradation of CD47 to Promote Tumor Immune Evasion

Advanced Science, 2023
Tumor cells often overexpress immune checkpoint proteins, including CD47, for immune evasion. However, whether or how oncogenic activation of receptor tyrosine kinases, which are crucial drivers in tumor development, regulates CD47 expression is unknown.
Linyong Du, Zhipeng Su, Silu Wang, Ying Meng, Fei Xiao, Daqian Xu, Xinjian Li, Xu Qian, Su Bin Lee, Jong‐Ho Lee, Zhimin Lu, Jianxin Lyu   +11 more
doaj   +1 more source

CD47 Potentiates Inflammatory Response in Systemic Lupus Erythematosus

Cells, 2021
Background: To investigate the role of CD47 in inflammatory responses in systemic lupus erythematosus (SLE). Methods: Expression of CD47 and signal regulatory protein alpha (SIRPα) by peripheral blood mononuclear cells (PBMCs) and changes in CD47 ...
Jin Kyun Park, Ye Ji Lee, Ji Soo Park, Eun Bong Lee, Yeong Wook Song   +4 more
doaj   +1 more source

CD47 expression is critical for CAR T-cell survival in vivo

Journal for ImmunoTherapy of Cancer, 2023
Background CD47 is an attractive immunotherapeutic target because it is highly expressed on multiple solid tumors. However, CD47 is also expressed on T cells.
Stephen Gottschalk, Phuong Nguyen, Christopher DeRenzo, Giedre Krenciute, Alex N Beckett, Peter Chockley, Shondra M Pruett-Miller, Peter Vogel, Heather Sheppard   +8 more
doaj   +1 more source