Results 1 to 10 of about 38,316 (246)

Harnessing the innate immune system: a novel bispecific antibody targeting CD47 and CD24 for selective tumor clearance [PDF]

Journal for ImmunoTherapy of Cancer
Background Tumor-associated macrophages (TAMs) abundantly infiltrate tumors and possess potent antitumor capabilities. “Don‘t eat me” signals like CD47 allow tumors to evade macrophages and proliferate unchecked.
Chao Wang, Juan Zhang, Yi Luo, Yifei Wang, Weifeng Huang, Shaogang Peng, Andy Tsun, Xiaoniu Miao, Liandi Chen, Lidi Nan, Huayuan Liao, Ziyue Cui, Yanqing Lv, Xiaomu Wang   +13 more
doaj   +2 more sources

CD47 expression in solid tumors correlates with phagocytic tumor-associated macrophage gene signature [PDF]

Frontiers in Immunology
BackgroundCD47 is a “don’t eat me” signal that is overexpressed in tumors to evade phagocytosis by tumor associated macrophages (TAM). Investigational agents targeting CD47, such as magrolimab, aim to induce phagocytosis of tumor cells by TAMs ...
Nicholas van Buuren, Nicholas van Buuren, Mengshu Xu, Mengshu Xu, Yi Zhang, Paola Correa, Shiva Zaboli, Azadeh Madjidi, Christina Moon, Szu-Wen Liu, Ruidong Li, Kai-Hui Sun, Shahed Iqbal, Abhishek Aggarwal, Min Wang, Li Li, Jared M. Odegard, Jared M. Odegard, Kelli Boyd   +18 more
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CD47 cross-dressing by extracellular vesicles expressing CD47 inhibits phagocytosis without transmitting cell death signals

eLife, 2022
Transgenic CD47 overexpression is an encouraging approach to ameliorating xenograft rejection and alloresponses to pluripotent stem cells, and the efficacy correlates with the level of CD47 expression. However, CD47, upon ligation, also transmits signals
Yang Li, Yan Wu, Elena A Federzoni, Xiaodan Wang, Andre Dharmawan, Xiaoyi Hu, Hui Wang, Robert J Hawley, Sean Stevens, Megan Sykes, Yong-Guang Yang   +10 more
doaj   +1 more source

Human lung adenocarcinoma CD47 is upregulated by interferon-γ and promotes tumor metastasis

Molecular Therapy: Oncolytics, 2022
Tumor cells can evade attack by phagocytes by upregulating the self-marker CD47. The mechanisms underlying tumor CD47 upregulation, however, remain unclear.
Shuang Qu, Zichen Jiao, Geng Lu, Jiahan Xu, Bing Yao, Ting Wang, Jun Wang, Yongzhong Yao, Xin Yan, Tao Wang, Hongwei Liang, Ke Zen   +11 more
doaj   +1 more source

EGFR‐Induced and c‐Src‐Mediated CD47 Phosphorylation Inhibits TRIM21‐Dependent Polyubiquitylation and Degradation of CD47 to Promote Tumor Immune Evasion

Advanced Science, 2023
Tumor cells often overexpress immune checkpoint proteins, including CD47, for immune evasion. However, whether or how oncogenic activation of receptor tyrosine kinases, which are crucial drivers in tumor development, regulates CD47 expression is unknown.
Linyong Du, Zhipeng Su, Silu Wang, Ying Meng, Fei Xiao, Daqian Xu, Xinjian Li, Xu Qian, Su Bin Lee, Jong‐Ho Lee, Zhimin Lu, Jianxin Lyu   +11 more
doaj   +1 more source

CD47 Potentiates Inflammatory Response in Systemic Lupus Erythematosus

Cells, 2021
Background: To investigate the role of CD47 in inflammatory responses in systemic lupus erythematosus (SLE). Methods: Expression of CD47 and signal regulatory protein alpha (SIRPα) by peripheral blood mononuclear cells (PBMCs) and changes in CD47 ...
Jin Kyun Park, Ye Ji Lee, Ji Soo Park, Eun Bong Lee, Yeong Wook Song   +4 more
doaj   +1 more source

CD47 expression is critical for CAR T-cell survival in vivo

Journal for ImmunoTherapy of Cancer, 2023
Background CD47 is an attractive immunotherapeutic target because it is highly expressed on multiple solid tumors. However, CD47 is also expressed on T cells.
Stephen Gottschalk, Phuong Nguyen, Christopher DeRenzo, Giedre Krenciute, Alex N Beckett, Peter Chockley, Shondra M Pruett-Miller, Peter Vogel, Heather Sheppard   +8 more
doaj   +1 more source

CD47 as a Potential Target to Therapy for Infectious Diseases

Antibodies, 2020
The integrin associated protein (CD47) is a widely and moderately expressed glycoprotein in all healthy cells. Cancer cells are known to induce increased CD47 expression.
Lamin B. Cham, Tom Adomati, Fanghui Li, Murtaza Ali, Karl S. Lang   +4 more
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CD47(low) status on CD4 effectors is necessary for the contraction/resolution of the immune response in humans and mice. [PDF]

PLoS ONE, 2012
How do effector CD4 T cells escape cell death during the contraction of the immune response (IR) remain largely unknown. CD47, through interactions with thrombospondin-1 (TSP-1) and SIRP-α, is implicated in cell death and phagocytosis of malignant cells.
Vu Quang Van, Nobuyasu Baba, Manuel Rubio, Keiko Wakahara, Benoit Panzini, Carole Richard, Genevieve Soucy, Denis Franchimont, Genevieve Fortin, Ana Carolina Martinez Torres, Lauriane Cabon, Santos Susin, Marika Sarfati   +12 more
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CD47 Enhances Cell Viability and Migration Ability but Inhibits Apoptosis in Endometrial Carcinoma Cells via the PI3K/Akt/mTOR Signaling Pathway

Frontiers in Oncology, 2020
Purposes: To measure expression levels of CD47 during endometrial carcinoma development, and to determine specific modulatory effects.Methods: CD47 expression levels in endometrial carcinoma tissues and adjacent tissues were analyzed using qRT-PCR.
Yun Liu, Yue Chang, Xinhong He, Yixuan Cai, Hao Jiang, Ru Jia, Jiyan Leng   +6 more
doaj   +1 more source