Results 131 to 140 of about 36,599 (239)

CD47, a novel YAP target gene, contributes to hepatic stellate cell activation and liver fibrosis induced by high-fat diet

Heliyon
Activated hepatic stellate cells (HSCs) have been widely recognized as a primary source of pathological myofibroblasts, leading to the accumulation of extracellular matrix and liver fibrosis. CD47, a transmembrane glycoprotein expressed on the surface of
Ya Li, Lin Dong, Xuecui Yin, Xiaohan Wang, Xiaohui Zhu, Pengyuan Zheng, Youcai Tang   +6 more
doaj   +1 more source

Engineering macrophages to eat cancer: from “marker of self” CD47 and phagocytosis to differentiation [PDF]

, 2017
Cory Alvey, Dennis E. Discher
openalex   +1 more source

Bioengineered Extracellular Vesicles in Emerging Cancer Vaccine Platforms

Small Science, EarlyView.
This review highlights recent advances in engineering extracellular vesicles (EVs) as next‐generation cancer vaccines. It outlines their biological roles and antigen‐presenting capacity, explores key strategies for antigen loading and delivery optimization, and summarizes preclinical and clinical applications using EVs from diverse immune and tumor ...
Wonkyung Ahn, Yeram Lee, Gi‐Hoon Nam, Jae Bem You, Eun Jung Lee   +4 more
wiley   +1 more source

CD47 blockade ameliorates autoimmune vasculitis via efferocytosis of neutrophil extracellular traps [PDF]

, 2023
Satoka Shiratori‐Aso, Daigo Nakazawa, Takashi Kudo, Masatoshi Kanda, Y Ueda, Kanako Watanabe‐Kusunoki, Saori Nishio, Sari Iwasaki, Takahiro Tsuji, Sakiko Masuda, Utano Tomaru, Akihiro Ishizu, Tatsuya Atsumi   +12 more
openalex   +1 more source

Unlocking the Architecture and Component Distribution of Bioengineered and Derived Colloidal Structures from Blood with Neutron Scattering

Small Structures, EarlyView.
Blood‐ and red blood cell (RBC)‐derived colloids are promising biomedical materials but are structurally complex. This work demonstrates how small‐ and ultra‐small‐angle neutron scattering (SANS and USANS) with contrast variation reveal the micro/nanoarchitectures of RBC ghosts, extracellular vesicles (EVs), and plasma proteins.
Cuong Viet Pham, Haikun Liu, Joshua P. King, Shulei Ren, Sylvain Trépout, Alexis I. Bishop, Rico F. Tabor, Karlheinz Peter, Liliana de Campo, Mark Louis P. Vidallon, Xiaowei Wang   +10 more
wiley   +1 more source

PET/NIR‐II fluorescence imaging and image‐guided surgery of breast cancer using a CD47‐specific nanobody

VIEW, EarlyView.
A CD47‐targeted dual‐modal imaging probe combining positron emission tomography and second near‐infrared fluorescence enables precise preoperative tumor localization and intraoperative guidance for complete resection of breast cancer lesions, including metastases, offering a promising strategy to enhance surgical accuracy and improve clinical outcomes.
Jun Li, Runge Zhao, Jinyuan Zhang, Zixuan Huang, Xiaoyan Wang, Rui Zhang, Chenghui Zheng, Mengjie Dong, Yongsheng Zhao, Jing Mu   +9 more
wiley   +1 more source

Bionic nanobombs target nasopharyngeal carcinoma to enhance the efficacy of chemoradiotherapy by destroying DNA damage repair systems

VIEW, EarlyView.
A bionic nanomedicine system with core–shell structure (Nm‐pAu/CP/KU) was constructed. PEGylated gold nanoparticles (pAu) were loaded with cisplatin (CP) and a radiochemotherapy sensitizer (KU‐60019) to form the core pAu/CP/KU, and homologous nasopharyngeal carcinoma cell membrane vesicles (Nm) were used as the shell.
Junhua Zhang, Xinying Xiang, Xinmin Nie, Jian Li, Rong Gui   +4 more
wiley   +1 more source

“Marker of Self” CD47 on lentiviral vectors decreases macrophage-mediated clearance and increases delivery to SIRPA-expressing lung carcinoma tumors [PDF]

, 2016
Nisha Sosale, Irena I. Ivanovska, Richard Tsai, Joe Swift, Jake Hsu, Cory Alvey, Philip W. Zoltick, Dennis E. Discher   +7 more
openalex   +1 more source

1096 A novel viral immunotherapeutic targeting the CD47/SIRPα axis demonstrates potent anti-tumor effects

, 2023
Anne R. Diers, Qiuchen Guo, John D. Christie, David Krisky, Paul P. Tak, Francesca Barone   +5 more
openalex   +1 more source

Oncolytic adenovirus H101 enhanced antitumor effects of PD-1 blockade by downregulating CD47 on tumor cells [PDF]

, 2023
Chenxiao Qiao, Song Wang, Yipeng Xu, Yedie He, Zhijian Cai, Hua Wang   +5 more
openalex   +1 more source