Results 131 to 140 of about 38,316 (246)

B7-H3 and CD47 co-expression in gastric cancer is a predictor of poor prognosis and potential targets for future dual-targeting immunotherapy [PDF]

, 2023
Siji Chen, Shenghua Zhan, Sisi Ding, Qiange Zhang, Hanqin Xuan, Xueguang Zhang, Lei Cao   +6 more
openalex   +1 more source

Beyond PD‐1: Mechanisms of Resistance to Checkpoint Blockade in Classical Hodgkin Lymphoma and Next‐Generation Immune Strategies

European Journal of Haematology, EarlyView.
ABSTRACT PD‐1 inhibitors have reshaped the treatment landscape of classical Hodgkin lymphoma, yet a substantial proportion of patients exhibit primary or acquired resistance driven by tumor‐intrinsic alterations, immunosuppressive microenvironmental signals, metabolic constraints, and EBV‐mediated modulation.
Santino Caserta, Enrica Antonia Martino, Mamdouh Skafi, Maria Eugenia Alvaro, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Ernesto Vigna, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

CD47 Ligation Repositions the Inhibitory Receptor SIRPA to Suppress Integrin Activation and Phagocytosis

, 2020
Meghan A. Morrissey, Nadja Kern, Ronald D. Vale   +2 more
openalex   +2 more sources

Promising alternatives of CD47 monoclonal antibody: an injectable degradable hydrogel loaded with PQ912 for postoperative immunotherapy effectively blocks CD47-SIRPα signal [PDF]

, 2022
Chang Li, Yubo Liu, Dan Li, Qiu Wang, Shuang Zhou, Haotian Zhang, Yongjun Wang, Zhonggui He, Hongzhuo Liu, Jin Sun   +9 more
openalex   +1 more source

Xenotransplantation at a Crossroads: Breakthroughs, Challenges, and the Path Forward

Organ Medicine, EarlyView.
Xiaoyu Gan, Jizhang Yu, Jie Wu, Junjie Zong   +3 more
wiley   +1 more source

MyD88 Deficiency Protects Mice From Experimental Autoimmune Encephalomyelitis by Influencing Both Dendritic Cells and T Cells

Immunology, EarlyView.
This study investigates the role of MyD88 in dendritic cells (DCs) and T cells during experimental autoimmune encephalomyelitis (EAE). We found that MyD88 is highly expressed in DCs and CD4+ T cells in people with multiple sclerosis, and its deficiency impairs DC maturation, reduces pro‐inflammatory cytokine production, weakens DC–T cell interactions ...
Wen Si, Gaochen Zhu, Qianling Jiang, Xin Ma, Guan Yang   +4 more
wiley   +1 more source

Is CD47 an innate immune checkpoint for tumor evasion? [PDF]

, 2017
Xiaojuan Liu, Hyunwoo Kwon, Zihai Li, Yang-Xin Fu   +3 more
openalex   +1 more source

589 Enhancement of the anti-tumor effects of CD47 blockade in solid tumors by combination with targeted radioimmunotherapy [PDF]

, 2021
Sagarika Pachhal, Emily Greer, Jesse Hwang, Qing Liang, Mary Chen, Eileen M. Geoghegan, Helen Kotanides, Dale L. Ludwig, Denis Beckford   +8 more
openalex   +1 more source

Bacterial Extracellular Vesicles in the Pathogenesis and Treatment of Liver Diseases

Journal of Gastroenterology and Hepatology, EarlyView.
Liver diseases are a major global health challenge, with current treatments inadequate. This review highlights the role of bacterial extracellular vesicles in liver inflammation, fibrosis, and metabolism. We also explore these from commensals and probiotics, their protective effects, and discuss research challenges and future therapeutic potential ...
Yakun Li, Jia Li, Robin P. F. Dullaart, Han Moshage   +3 more
wiley   +1 more source

Immune involvement in neuropsychiatric disorders: Insights from single‐cell transcriptomic studies

Psychiatry and Clinical Neurosciences, EarlyView.
Neuropsychiatric disorders pose profound challenges to both research and treatment, largely due to their clinical heterogeneity and the limited understanding of their underlying biological mechanisms. While bulk RNA sequencing (bulk RNA‐seq) has been widely used to study gene expression, it cannot resolve cell‐type‐specific signals or detect rare ...
Tsutomu Takeda, Michihiro Toritsuka, Hiroto Tamakoshi, Nakao Iwata, Manabu Makinodan   +4 more
wiley   +1 more source