Results 51 to 60 of about 36,599 (239)

Digitonin‐Loaded Nanoscale Metal–Organic Framework for Mitochondria‐Targeted Radiotherapy‐Radiodynamic Therapy and Disulfidptosis

Advanced Materials, EarlyView.
A mitochondria‐targeted cationic nanoscale metal organic framework shows strong radiotherapy‐radiodynamic therapy effects and selectively releases digitonin in acidic tumor microenvironments to induce disulfidptosis of cancer cells and downregulate immune checkpoints in cancer and T cells, thereby eliciting strong antitumor immunity to effectively ...
Wenyao Zhen, Yingjie Fan, Tomas Germanas, Langston Tillman, Jinhong Li, Abigail L. Blenko, Ralph R. Weichselbaum, Wenbin Lin   +7 more
wiley   +1 more source

Rapid Dendritic Cell Activation and Resistance to Allotolerance Induction in Anti-CD154-Treated Mice Receiving CD47-Deficient Donor-Specific Transfusion

Cell Transplantation, 2014
CD47–SIRPα signaling plays an important role in regulating macrophage and dendritic cell (DC) activation. Here we investigated the role of CD47 expression on donor cells in tolerance induction by combined treatment with donor-specific transfusion (DST ...
Yuantao Wang, Hui Wang, Roderick Bronson, Yaowen Fu M.D., Ph.D., Yong-Guang Yang M.D., Ph.D.   +4 more
doaj   +1 more source

Deletion of CD47 from Schwann cells and macrophages hastens myelin disruption/dismantling and scavenging in Schwann cells and augments myelin debris phagocytosis in macrophages

Journal of Neuroinflammation, 2023
Background Myelin that surrounds axons breaks in trauma and disease; e.g., peripheral nerve and spinal cord injuries (PNI and SCI) and multiple sclerosis (MS).
Miri Gitik, Gerard Elberg, Fanny Reichert, Michael Tal, Shlomo Rotshenker   +4 more
doaj   +1 more source

CD47 Deficiency Ameliorates Ocular Autoimmune Inflammation

Frontiers in Immunology, 2021
Autoimmune uveitis is a sight-threatening ocular inflammatory condition in which the retina and uveal tissues become a target of autoreactive immune cells.
Yoko Okunuki, Steven J. Tabor, May Y. Lee, Kip M. Connor   +3 more
doaj   +1 more source

Multimodal Actuation and Environment Adaptive Strategies of Bio‐Inspired Micro/Nanorobots in Precision Medicine

Advanced Robotics Research, EarlyView.
An introduction for multidrive and environment‐adaptive micro/nanorobotics: design and fabrication strategies, intelligent actuation, and their applications. Various intelligent actuation approaches—magnetic, acoustic, optical, chemical, and biological—can be synergistically designed to enhance flexibility and adaptive behavior for precision medicine ...
Aiqing Ma, Han Gong, Jiacheng Ouyang, Liqi Chen, Tianfang Kang, Yiran He, Guojun Huang, Sidi Zheng, Ting Yin, Hong Pan, Lintao Cai   +10 more
wiley   +1 more source

CD47 is a direct target of SNAI1 and ZEB1 and its blockade activates the phagocytosis of breast cancer cells undergoing EMT

OncoImmunology, 2018
We report that CD47 was upregulated in different EMT-activated human breast cancer cells versus epithelial MCF7 cells. Overexpression of SNAI1 or ZEB1 in epithelial MCF7 cells activated EMT and upregulated CD47 while siRNA-mediated targeting of SNAI1 or ...
Muhammad Zaeem Noman, Kris Van Moer, Vanessa Marani, Robert M. Gemmill, Léon-Charles Tranchevent, Francisco Azuaje, Arnaud Muller, Salem Chouaib, Jean Paul Thiery, Guy Berchem, Bassam Janji   +10 more
doaj   +1 more source

CD47 Expression in Natural Killer Cells Regulates Homeostasis and Modulates Immune Response to Lymphocytic Choriomeningitis Virus

Frontiers in Immunology, 2018
CD47 is a ubiquitous cell surface receptor that directly regulates T cell immunity by interacting with its inhibitory ligand thrombospondin-1 and limits clearance of cells by phagocytes that express its counter-receptor signal-regulatory protein-α ...
Pulak Ranjan Nath, Arunakumar Gangaplara, Dipasmita Pal-Nath, Ajeet Mandal, Dragan Maric, John M. Sipes, Maggie Cam, Ethan M. Shevach, David D. Roberts   +8 more
doaj   +1 more source

Analysis of meteorological data from RRS Charles Darwin cruises CD46 and CD47 (BOFS experiment) [PDF]

, 1993
The IOSDL MultiMet meteorological instrumentation system was used during the BOFS experiment on RRS Charles Darwin cruises 46 and 47. This report describes and evaluates the quality of the meteorological data obtained.
Birch, K.G., Pascal, R.W., Taylor, P.K., Tiddy, R.J.   +3 more
core  

Lifespan‐Regulated CAR‐Macrophages from Myeloid Progenitors for Enhanced Colorectal Cancer Therapy

Advanced Science, EarlyView.
Using a tamoxifen‐inducible Hoxb8 system, proliferative bone marrow progenitors can be generated, which are subsequently engineered with an anti‐CEA CAR construct containing a suicide gene (iCas9) and differentiated into CAR‐macrophages. This method facilitates scale up the production of CAR‐macrophages.
Chuancheng Gao, Fangling Hong, Yao Dong, Yong Fu, Yunong Ma, Xuedi Sun, Junfeng Zhang, Jiangning Chen, Zhen Huang   +8 more
wiley   +1 more source

MGMT unmethylation and high levels of CD47 and TIGIT indicate a poor prognosis in adult diffuse gliomas

Frontiers in Immunology
IntroductionIn 2021, the World Health Organization published a new classification system for central nervous system tumors. This study reclassified the adult diffuse glioma (ADG) into astrocytoma, oligodendroglioma, and glioblastoma (GBM) according to ...
Lingbo Ma, Yi Shi, Chang Li, Bin Deng, Jinfang Jiang, Yuwen Cao, Lianghai Wang, Hongyan Li   +7 more
doaj   +1 more source