Results 111 to 120 of about 293,060 (357)

Strategies to Design and Optimize Artificial Antigen‐Presenting Cells for T Cell Expansion in Cancer Immunotherapy

Advanced Functional Materials, EarlyView.
This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley   +1 more source

Genomic Variants Associated with Haematological Parameters and T Lymphocyte Subpopulations in a Large White and Min Pig Intercross Population

Animals
The breeding of disease-resistant pigs has consistently been a topic of significant interest and concern within the pig farming industry. The study of pig blood indicators has the potential to confer economic benefits upon the pig farming industry ...
Naiqi Niu, Runze Zhao, Ming Tian, Wencheng Zong, Xinhua Hou, Xin Liu, Ligang Wang, Lixian Wang, Longchao Zhang   +8 more
doaj   +1 more source

MicroRNA-29 family expression and its relation to antiviral immune response and viro-immunological markers in HIV-1-infected patients [PDF]

, 2015
BACKGROUND: Several in vitro studies suggested the microRNA-29 (miRNA-29) family is involved in regulating HIV-1 and modulating the expression of interleukin (IL)-32, an anti-HIV-1 cytokine.
ANTONELLI, Guido, Cacciotti G, D'ETTORRE, Gabriella, FALASCA, FRANCESCA, MEZZAROMA, Ivano, MONTELEONE, Katia, SCAGNOLARI, CAROLINA, SELVAGGI, CARLA, TURRIZIANI, Ombretta, VULLO, Vincenzo   +9 more
core   +2 more sources

Endocytic Programming via Porous Silicon Nanoparticles Enhances TLR4 Nanoagonist Potency for Macrophage‐Mediated Immunotherapy

Advanced Functional Materials, EarlyView.
Porous silicon nanoparticles (PSiNPs) reprogram macrophage endocytosis of manganese@albumin‐based TLR4 nanoagonists, driving TRIF‐biased TLR4 signaling, eliciting robust proinflammatory responses, and potentiating macrophage‐mediated immunotherapeutic effects against NSCLC.
Xiaomei Zhang, Huiying Li, Shuodan Huang, Linxuan Zhang, Yan Gao, Ruoran Wang, Xiaoyu Wang, Hélder A. Santos, Zhenyu Yin, Bing Xia   +9 more
wiley   +1 more source

Assessment of HIV disease progression before and after initiation of anti­retroviral therapy by CD4 & CD8 T-lymphocyte count and viral load assay

Bangabandhu Sheikh Mujib Medical University Journal, 2016
Backgrounds: As there is no published data regarding the response to Anti-retroviral therapy (ART) among HIV patients from Bangladesh. The present study was designed to determine the immunological and virological responses of HIV infected Bangladeshi ...
Sahina Tabassum, S.M. Rashed-ul Islam, Afzalun Nessa, Munira Jahan, Saif Ullah Munshi   +4 more
doaj   +1 more source

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

Effect of HIV infection and antiretroviral therapy on hepatitis B virus (HBV)-specific T cell responses in patients who have resolved HBV infection [PDF]

, 2005
Coinfection with hepatitis B virus (HBV) is a common occurrence in human immunodeficiency virus (HIV)–positive patients and an increasing cause of morbidity and mortality.
Bertoletti, A., Copas, A., Dunn, C., Gilson, R.J., Johnstone, R., Lascar, R.M., Lopes, A.R., Maini, M.K., Reignat, S., Webster, G.   +9 more
core   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Real World Lab Data: Patterns of Lymphocyte Counts in Fingolimod Treated Patients

Frontiers in Immunology, 2018
Objective:Fingolimod is approved for the treatment of highly active relapsing remitting multiple sclerosis (MS) patients and acts by its unique mechanism of action via sphingosine-1-phosphate receptor-modulation.
Maxi Kaufmann, Rocco Haase, Undine Proschmann, Tjalf Ziemssen, Katja Akgün   +4 more
doaj   +1 more source

STAT3 mutation impacts biological and clinical features of T-LGL leukemia [PDF]

, 2017
STAT3 mutations have been described in 30-40% of T-large granular lymphocyte (T-LGL) leukemia patients, leading to STAT3 pathway activation. Considering the heterogeneity of the disease and the several immunophenotypes that LGL clone may express, the aim
BARILA', GREGORIO, BERNO, TAMARA, BOSCARO, ELISA, CABRELLE, ANNA, CALABRETTO, GIULIA, DE MARCH, ELENA, ERCOLIN, CHIARA, FACCO, MONICA, GATTAZZO, CRISTINA, Lamy, Thierry, LEONCIN, MATTEO, Moignet, Aline, PAGNIN, ELISA, Pastoret, C\ue9dric, PIAZZA, FRANCESCO, Roussel, Mikael, SEMENZATO, GIANPIETRO CARLO, Teolato, Sara, TERAMO, ANTONELLA, TRENTIN, LIVIO, ZAMBELLO, RENATO   +20 more
core   +1 more source