Results 21 to 30 of about 34,015 (256)

Systematic characterization of extracellular vesicle sorting domains and quantification at the single molecule – single vesicle level by fluorescence correlation spectroscopy and single particle imaging

open access: yesJournal of Extracellular Vesicles, 2019
Extracellular vesicles (EV) convey biological information by transmitting macromolecules between cells and tissues and are of great promise as pharmaceutical nanocarriers, and as therapeutic per se. Strategies for customizing the EV surface and cargo are
Giulia Corso   +13 more
doaj   +1 more source

Co-expression of TIMP-1 and its cell surface binding partner CD63 in glioblastomas

open access: yesBMC Cancer, 2018
Background We have previously identified tissue inhibitor of metalloproteinases-1 (TIMP-1) as a prognostic marker in glioblastomas. TIMP-1 has been associated with chemotherapy resistance, and CD63, a known TIMP-1-binding protein, has been suggested to ...
Charlotte Aaberg-Jessen   +6 more
doaj   +1 more source

The prognostic significance of CD63 expressionin patients with non-small cell lung cancer

open access: yesPolish Journal of Pathology, 2019
CD63 has been suggested to participate in tumorigenesis, invasion, and metastasis. In this study, we aimed to investigate the prognostic significance of CD63 expression in non-small cell lung cancer (NSCLC).
Hyun Koh, Hyo An, Jae Jung, Dae Song
doaj   +1 more source

Universal extracellular vesicles and PD-L1+ extracellular vesicles detected by single molecule array technology as circulating biomarkers for diffuse large B cell lymphoma

open access: yesOncoImmunology, 2021
Plasma extracellular vesicles (EVs) have been reported to be a promising source of diagnostic and prognostic biomarkers in various cancers. However, further research in this area is needed due to the limitations of circulating extracellular vesicles ...
Ji-Wei Li   +10 more
doaj   +1 more source

CD63+ Cancer‐Associated Fibroblasts Confer Tamoxifen Resistance to Breast Cancer Cells through Exosomal miR‐22

open access: yesAdvanced Science, 2020
Tamoxifen remains the most effective treatment for estrogen receptor α (ERα)‐positive breast cancer. However, many patients still develop resistance to tamoxifen in association with metastatic recurrence, which presents a tremendous clinical challenge ...
Yuan Gao   +14 more
doaj   +1 more source

Plasma extracellular vesicles detected by Single Molecule array technology as a liquid biopsy for colorectal cancer

open access: yesJournal of Extracellular Vesicles, 2020
Circulating extracellular vesicles (EVs) were recognized as a promising source of diagnostic biomarker. However, there are limited studies published in this area, partly due to the limited number of detection platforms capable of detecting extracellular ...
Ping Wei   +7 more
doaj   +1 more source

Expression of CD63 in Lung Tissue of Guinea Pigs Dying of Anaphylactic Shock [PDF]

open access: yesFayixue Zazhi, 2019
Objective To study the protein expression of cluster of differentiation 63 (CD63) in lung tissues of guinea pigs that died of anaphylactic shock and discuss the diagnostic value of CD63 for death from anaphylactic shock.
ZHANG Chu-nan, YU Hao, WANG Xiao-long,et al
doaj   +1 more source

The Exosome‐Associated Tetraspanin CD63 Contributes to the Efficient Assembly and Infectivity of the Hepatitis B Virus

open access: yesHepatology Communications, 2021
Currently, the hepatocellular trafficking pathways that are used by the hepatitis B virus (HBV) during viral infection and shedding are poorly defined. It is known that the HBV uses late endosomal and multivesicular body (MVB) compartments for assembly ...
Masashi Ninomiya   +6 more
doaj   +1 more source

The tetraspanin Cd63 is required for eye morphogenesis in Xenopus

open access: yesmicroPublication biology, 2020
Tetraspanins (TSPAN) are a family of (33 in humans) scaffold proteins consisting of the name-giving four membrane-spanning domains, two extracellular loops, and an intracellular N- and C-terminus. By forming ‘tetraspanin-enriched microdomains’ they participate in organizing the plasma membrane and serve as multipurpose adapters.
Kreis, Jennifer   +2 more
openaire   +2 more sources

Regulation of Tumor Metabolism and Extracellular Acidosis by the TIMP-10–CD63 Axis in Breast Carcinoma

open access: yesCells, 2021
A hallmark of malignant solid tumor is extracellular acidification coupled with metabolic switch to aerobic glycolysis. Using the human MCF10A progression model of breast cancer, we show that glycolytic switch and extracellular acidosis in aggressive ...
Abdo J. Najy   +4 more
doaj   +1 more source

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