Results 191 to 200 of about 50,598 (255)

Nanomedicine Targeting Macrophage Immunometabolism in Atherosclerosis: Mechanisms and Therapeutic Prospects

Organ Medicine, Volume 3, Issue 1, Page 27-53, March 2026.
ABSTRACT Atherosclerosis, a chronic inflammatory–metabolic disorder, remains a leading cause of cardiovascular morbidity worldwide. This review explores the emerging paradigm of nanomedicine‐based targeting of macrophage immunometabolic reprogramming as a potentially transformative strategy for atherosclerosis treatment.
Zhenyu Liu, Wenfan Yang, Na Wang, Ya Wu
wiley   +1 more source

CD39 in the pathogenesis of neuro-Behçet disease: is it an immune regulator marker? [PDF]

Front Immunol
Bahrini K, Stiti A, Boughariou S, Belghith M.   +3 more
europepmc   +1 more source

Physiologically Based Pharmacokinetic Virtual Twin Approach for Fludarabine Dosing in Pediatric Hematopoietic Stem Cell Transplantation

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 3, March 2026.
ABSTRACT Fludarabine (Flu), administered as a prodrug Flu monophosphate, is a lymphodepleting agent used prior to hematopoietic stem cell transplantation (HSCT) which exhibits substantial pharmacokinetics (PK) variability, contributing to suboptimal outcomes.
Mourad Mseddi, Christa Nath, Khalil Ben Hassine, Vid Mlakar, Yvonne Gloor, Fanny Gonzales, Chakradhara Rao S. Uppugunduri, Youssef Daali, Steven Keogh, Marc Ansari   +9 more
wiley   +1 more source

Targeting CD73 and correcting adenosinergic signaling in critically ill patients. [PDF]

Front Pharmacol
Lunderberg JM, Spicer AJ, Cassavaugh J, Jalkanen J, Haskó G, Robson SC.   +5 more
europepmc   +1 more source

Anti-CD73 Monoclonal Antibody NZV930 [PDF]

, 2020
openaire   +1 more source

T‐Cell Immunity and Lung Cancer

Respirology, Volume 31, Issue 3, Page 236-249, March 2026.
ABSTRACT Lung cancer remains a leading cause of cancer mortality worldwide. Although immune checkpoint inhibitors (ICIs) have reshaped therapeutic strategies in lung cancer, their benefits remain limited. ICIs exert their therapeutic efficacy by activating T‐cell effector functions, underscoring the central role of T cells in antitumor immunity.
Kotaro Yamada, Yosuke Togashi
wiley   +1 more source

Spatiotemporal dynamics of ecto-5'-nucleotidase (CD73) in mouse retina under physiological conditions. [PDF]

Development
Ishii R, Sakurai K, Hosomi N, Fleischmann BK, Mizuno S, Kimura K, Yanagisawa H.   +6 more
europepmc   +1 more source

The X Factor in Immunity: Sex Differences Shaped by the X Chromosome

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT There are sex differences with immune responses where females exhibit stronger immune responses compared to males. Both sex hormones and sex chromosome differences between males and females contribute to the observed sex differences with innate and adaptive immune cell composition and function.
Katherine B. Radovanovic, Megan Wynalda, Montserrat C. Anguera   +2 more
wiley   +1 more source

Ecto-5'-nucleotidase/CD73 reduces COX-2 expression in activated macrophages. [PDF]

Sci Rep
Rahman MM, Sircar A, Lakhina S, Kumar P, Gupta RD, Akundi RS.   +5 more
europepmc   +1 more source

Sex Differences in Metabolite–Immune Circuits of Neuroinflammation

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Sex is a fundamental yet underexplored determinant of human neuroinflammation. Across autoimmune, neurodegenerative, and post‐infectious neurological syndromes, males and females exhibit consistent differences in disease vulnerability, progression, and immune tone.
Priyanka Saminathan, Maija Corey, Alicia Gibbons, Mahati Rayadurgam, Neha Reddy, Pavithra Ramesh, Sonia Sharma   +6 more
wiley   +1 more source