Results 1 to 10 of about 93,380 (181)

CTLA-4 and PD-1 Ligand Gene Expression in Epithelial Thyroid Cancers [PDF]

International Journal of Endocrinology, 2018
The dysregulation of PD-1 ligands (PD-L1 and PD-L2) and CTLA-4 ligands (CD80 and CD86) represents a tumor strategy to escape the immune surveillance.
Chiara Tuccilli, Enke Baldini, Salvatore Sorrenti, Antonio Catania, Alessandro Antonelli, Poupak Fallahi, Francesco Tartaglia, Susi Barollo, Caterina Mian, Andrea Palmieri, Giovanni Carbotta, Stefano Arcieri, Daniele Pironi, Massimo Vergine, Massimo Monti, Salvatore Ulisse   +15 more
doaj   +3 more sources

CD80 expression promotes immune surveillance in Barrett’s metaplasia [PDF]

OncoImmunology, 2019
Esophageal adenocarcinoma (EAC) is the final step of a pathway starting with esophageal reflux disease, Barrett’s metaplasia and Barrett’s dysplasia.
Melania Scarpa, Matteo Fassan, Andromachi Kotsafti, Stefano Realdon, Luigi Dall’Olmo, Tiziana Morbin, Francesco Cavallin, Luca Saadeh, Matteo Cagol, Rita Alfieri, Carlo Castoro, Massimo Rugge, Ignazio Castagliuolo, Marco Scarpa   +13 more
doaj   +4 more sources

Rigid, bivalent CTLA-4 binding to CD80 is required to disrupt the cis CD80/PD-L1 interaction

Cell Reports
Summary: The CTLA-4 and PD-1 checkpoints control immune responses and are key targets in immunotherapy. Both pathways are connected via a cis interaction between CD80 and PD-L1, the ligands for CTLA-4 and PD-1, respectively. This cis interaction prevents
Maximillian A. Robinson, Alan Kennedy, Carolina T. Orozco, Hung-Chang Chen, Erin Waters, Dalisay Giovacchini, Kay Yeung, Lily Filer, Claudia Hinze, Christopher Lloyd, Simon J. Dovedi, David M. Sansom   +11 more
doaj   +3 more sources

FLT3-ITD promotes immune checkpoint CD80 via ROS elevation in acute myeloid leukemia [PDF]

Frontiers in Immunology
Acute myeloid leukemia (AML), a malignant hematological stem cell disease, arises from the malignant transformation of myeloid progenitor cells. Among the genetic aberrations in AML, mutations in the tyrosine kinase receptor FLT3, especially FLT3-ITD ...
Libo Yan, Weiming Zhang, Qiyan Mo, Daogang Wang, Ning Xu, Mengzhe Yang, Tao Ren   +6 more
doaj   +2 more sources

IRX-2, a Novel Immunotherapeutic, Enhances Functions of Human Dendritic Cells [PDF]

, 2013
Background: In a recent phase II clinical trial for HNSCC patients, IRX-2, a cell-derived biologic, promoted T-cell infiltration into the tumor and prolonged overall survival. Mechanisms responsible for these IRX-2-mediated effects are unknown.
A Lopez-Albaitero, A Pinzon-Charry, AD Rapidis, B Almand, B Schilling, Bastian Schilling, C Reis e Sousa, C Sadhu, C Visus, D Agnello, Derya Unutmaz, DI Gabrilovich, DS Heo, DY Ma, E Procko, GG Kim, GT Wolf, H Jonuleit, H Jonuleit, H Okada, IK Poon, J Banchereau, James Egan, JE Egan, JM Kirkwood, L Frasca, LH Butterfield, M Ahmadi, M Temponi, Malgorzata Harasymczuk, MC Dieu, MR Young, N Bandoh, NL Berinstein, P Chaux, P Kalinski, P Langlade-Demoyen, Patrick Schuler, R Muthuswamy, S Amigorena, Soldano Ferrone, T Ogino, Theresa L. Whiteside, TK Hoffmann, TK Hoffmann, TL Whiteside, TL Whiteside, X Wang   +47 more
core   +26 more sources

CD80 Antibody and MTX Co-Engineered Extracellular Vesicles Targets CD80+ Macrophages to Suppress Inflammation and Alleviate Chronic Inflammatory Diseases

International Journal of Nanomedicine
Jianhua Yang,1,* Handan Zhang,2,* Wenzhe Wang,1,* Qiqi Yin,2,* Xiaoning He,1 Dihao Tao,1 Hanzhe Wang,1 Wenhao Liu,1 Yiming Wang,1 Zhiwei Dong,3 Xin Chen,2 Bei Li1 1State Key Laboratory of Oral & Maxillofacial ...
Yang J, Zhang H, Wang W, Yin Q, He X, Tao D, Wang H, Liu W, Wang Y, Dong Z, Chen X, Li B   +11 more
doaj   +2 more sources

Expression of CD80 and HLA-DR molecules on blood monocytes in patients with pulmonary tuberculosis

Медицинская иммунология, 2021
We examined expression pattern of CD80 and HLA-DR pro-inflammatory molecules on the monocytes in patients with pulmonary tuberculosis (TB), depending on the clinical form of the disease and susceptibility of the pathogen to anti-tuberculosis drugs.
E. G. Churina, A. V. Popova, O. I. Urazova, M. R. Patysheva, S. P. Chumakova, Yu. V. Kolobovnikova, E. O. Kazakova   +6 more
doaj   +1 more source

Elevated urinary CD80 excretion in children with steroid-responsive nephrotic syndrome

Biomedical and Biotechnology Research Journal, 2022
Background: Idiopathic nephrotic syndrome (INS) is one of the most common glomerular diseases in children with different pathological types and different responses to corticosteroids.
Nakysa Hooman, Hasan Otukesh, Rozita Hosseini, Azar Nickavar, Farzaneh Dastan, Mahboubeh Jafari Sarouei, Parisa Honarpisheh   +6 more
doaj   +1 more source

Novel approaches to increase resistance to acute respiratory infections

RUDN Journal of Medicine, 2021
Relevance . Respiratory infections are the most common in the world. In order to prevent epidemics, there is a need to improve the strategies for organizing medical care and develop new approaches in order to increase the nonspecific resistance, mobilize
Svetlana V. Guryanova, Natalia A. Kudryashova, Anastasiya A. Kataeva, Bubusaira T. Orozbekova, Natalia V. Kolesnikova, Alexandr G. Chuchalin   +5 more
doaj   +1 more source

Expression of pro-inflammatory and co-stimulatory molecules on the surface of macrophages in vitro in patients with pulmonary tuberculosis

Бюллетень сибирской медицины, 2021
The aim of this study was to identify features of the expression of pro-inflammatory and co-stimulatory molecules on the surface of macrophages in vitro in patients with pulmonary tuberculosis, depending on the clinical form of the disease and ...
E. G. Churina, A. V. Sitnikova, O. I. Urazova, V. V. Novitskiy, M. R. Patysheva, P. N. Golubchikov, E. P. Stepanova   +6 more
doaj   +1 more source