Results 11 to 20 of about 93,479 (280)

CD80 expression is upregulated by TP53 activation in human cancer epithelial cells

OncoImmunology, 2021
CD80 is recognized as one of the most potent costimulatory molecules by which immune cells limit cancer progression; however, the current understanding of the regulation of its expression on human tumor cells is limited. The TP53 tumor suppressor plays a
Melania Scarpa, Chiara Marchiori, Marco Scarpa, Ignazio Castagliuolo   +3 more
doaj   +1 more source

Characterization of Co-Stimulatory Ligand CD80/86 and Its Effect as a Molecular Adjuvant on DNA Vaccine Against Vibrio anguillarum in Flounder (Paralichthys olivaceus)

Frontiers in Immunology, 2022
The CD80/86 molecule is one of the important co-stimulatory ligands and involves antigen-specific immune responses by ligating with CD28 and then delivering the required second signal to T-cell activation. In this study, a CD80/86 homolog was identified,
Wenjing Liu, Jing Xing, Jing Xing, Xiaoqian Tang, Xiaoqian Tang, Xiuzhen Sheng, Heng Chi, Wenbin Zhan, Wenbin Zhan   +8 more
doaj   +1 more source

The landscape of CD28, CD80, CD86, CTLA4, and ICOS DNA methylation in head and neck squamous cell carcinomas

Epigenetics, 2020
CTLA-4 blocking therapeutic antibodies are currently under investigation in head and neck squamous cell carcinoma (HNSCC). A better understanding of the epigenetic regulation of the CD28 superfamily members CD28, CTLA-4, and ICOS and their B7 ligands ...
Luka de Vos, Ingela Grünwald, Emma Grace Bawden, Jörn Dietrich, Kathrin Scheckenbach, Constanze Wiek, Romina Zarbl, Friedrich Bootz, Jennifer Landsberg, Dimo Dietrich   +9 more
doaj   +1 more source

Maximal ‘CD80-uria’ with minimal change [PDF]

Kidney International, 2010
Differentiation between minimal-change disease and focal segmental glomerulosclerosis remains challenging, particularly at early stages in children and adults. Garin et al. identify urinary CD80 excretion levels as a potential marker to differentiate the former entity from the latter. Thus, CD80 expression on podocytes, which was initially described in
Kistler, Andreas D., Reiser, Jochen
openaire   +2 more sources

Inclusion of CD80 in HSV targets the recombinant virus to PD-L1 on DCs and allows productive infection and robust immune responses. [PDF]

PLoS ONE, 2014
CD80 plays a critical role in stimulation of T cells and subsequent control of infection. To investigate the effect of CD80 on HSV-1 infection, we constructed a recombinant HSV-1 virus that expresses two copies of the CD80 gene in place of the latency ...
Kevin R Mott, Sariah J Allen, Mandana Zandian, Omid Akbari, Pedram Hamrah, Hadi Maazi, Steven L Wechsler, Arlene H Sharpe, Gordon J Freeman, Homayon Ghiasi   +9 more
doaj   +1 more source

Extending the B7 (CD80) gene family [PDF]

Protein Science, 1994
AbstractB7‐1 and B7‐2 are members of the immunoglobulin superfamily (IgSF) and important regulators of T cell‐mediated immune responses. Despite sharing only limited sequence identity, B7‐1 and B7‐2 bind common receptors, CD28 and CTLA‐4, on T cells and have similar functional properties.
P S, Linsley, R, Peach, P, Gladstone, J, Bajorath   +3 more
openaire   +2 more sources

Clinicopathologic Evaluation of CD80, CD86, and PD-L1 Expressions with Immunohistochemical Methods in Malignant Melanoma Patients [PDF]

Türk Patoloji Dergisi
Objective: Diagnostic and prognostic biomarkers for malignant melanoma are crucial for treatment and for developing targeted therapies. Malignant melanoma is a highly immunogenic tumor, and its regression, treatment, and prognostic evaluation are ...
Esra COBANKENT AYTEKIN, Betul UNAL, Cumhur Ibrahim BASSORGUN, Ozlenen OZKAN   +3 more
doaj   +1 more source

Molecular and Clinical Characterization of CD80 Expression via Large-Scale Analysis in Breast Cancer

Frontiers in Pharmacology, 2022
Cancer immunotherapy is emerging as a novel promising therapy option for cancer patients. Despite the critical role of CD80 in the regulation of immune responses, the expression and biological functions of CD80 in breast cancer remain unknown.
Qin Zhang, Chaowei Gao, Jianqiang Shao, Shengze Zhang, Peng Wang, Zunyi Wang   +5 more
doaj   +1 more source

برهمکنش های مولکولی بین CTLA-4 و CD80/CD86 در تنظیم پاسخ های ایمنی: مقاله مروری [PDF]

Majallah-i Dānishkadah-i Pizishkī-i Dānishgāh-i ̒ Ulūm-i Pizishkī-i Mashhad.
یکی از اصلی ترین مکانیسم های تنظیم پاسخ های ایمنی برهم کنش متقابل CTLA-4 و CD80/CD86 است. CTLA-4 نوعی رسپتور مهاری و دارای لیگاندهای CD80/CD86 و مشترک با گیرنده کمک محرک CD28 است. CTLA-4 طی فرآیندی به نام ترانس ‌اندوسیتوزیس این لیگاندها را اندوسیتوز کرده
زهرا درویش خلیل آبادی, آمنه رئوف رحمتی, سید علیرضا اسماعیلی   +2 more
doaj   +1 more source

Bisdemethoxycurcumin and Its Cyclized Pyrazole Analogue Differentially Disrupt Lipopolysaccharide Signalling in Human Monocyte-Derived Macrophages [PDF]

, 2018
open11noSeveral studies suggest that curcumin and related compounds possess antioxidant and anti-inflammatory properties including modulation of lipopolysaccharide- (LPS-) mediated signalling in macrophage cell models. We here investigated the effects of

core   +1 more source