Results 21 to 30 of about 93,479 (280)

Calreticulin arms NK cells against leukemia

OncoImmunology, 2020
Calreticulin (CALR) exposed on the surface of cancer cells succumbing to therapy delivers robust phagocytic signals that support the activation of adaptive anticancer immune responses. Recent data from our group demonstrate that spontaneous CARL exposure
Jitka Fucikova, Justin P. Kline, Lorenzo Galluzzi, Radek Spisek   +3 more
doaj   +1 more source

Characterisation of the immune-related transcriptome in resected biliary tract cancers [PDF]

, 2017
Although biliary tract cancers (BTCs) are known to have an inflammatory component, a detailed characterisation of immune-related transcripts has never been performed.
Braconi, Chiara, Carotenuto, Pietro, Cascione, Luciano, Cillo, Umberto, Fassan, Matteo, Ghidini, Michele, Hahne, Jens C., Lampis, Andrea, Mescoli, Claudia, Previdi, Maria Chiara, Raj, Maya, Rimassa, Lorenza, Roncalli, Massimo, Rugge, Massimo, Said-Huntingford, Ian, Santoro, Armando, Torzilli, Guido, Trevisani, Francesco, Valeri, Nicola, Zerbi, Alessandro   +19 more
core   +3 more sources

A mucin-like peptide from Fasciola hepatica instructs dendritic cells with parasite specific Th1-polarizing activity [PDF]

, 2017
Fasciolosis is a trematode zoonosis of interest in public health and cattle production. We report here the immunostimulatory effect of a 66 mer mucin-like peptide from Fasciola hepatica (Fhmuc), which synergizes with lipopolysaccharide (LPS) to promote ...
Brossard, Natalie, Carmona, Carlos, Dergan Dylon, Leonardo Sebastian, Freire, Teresa, Noya, Verónica, Rabinovich, Gabriel Adrián, Rodríguez, Ernesto   +6 more
core   +1 more source

Tumor membrane-based vaccine immunotherapy in combination with anti-CTLA-4 antibody confers protection against immune checkpoint resistant murine triple-negative breast cancer

Human Vaccines & Immunotherapeutics, 2020
Triple-negative breast cancer (TNBC) afflicts women at a younger age than other breast cancers and is associated with a worse clinical outcome. This poor clinical outcome is attributed to a lack of defined targets and patient-to-patient heterogeneity in ...
Christopher D. Pack, Ramireddy Bommireddy, Luis E. Munoz, Jaina M. Patel, Erica N. Bozeman, Paulami Dey, Vijayaraghavan Radhakrishnan, Vincent F. Vartabedian, Kalpana Venkat, Sampath Ramachandiran, Shaker J. C. Reddy, Periasamy Selvaraj   +11 more
doaj   +1 more source

Molecular and Functional Analyses of the Primordial Costimulatory Molecule CD80/86 and Its Receptors CD28 and CD152 (CTLA-4) in a Teleost Fish

Frontiers in Immunology, 2022
The moderate activation of T cells in mammals requires the costimulatory molecules, CD80 and CD86, on antigen-presenting cells to interact with their respective T cell receptors, CD28 and CD152 (CTLA-4), to promote costimulatory signals.
Tao-Zhen Lu, Xun Liu, Chang-Song Wu, Zi-You Ma, Yang Wang, Yong-An Zhang, Yong-An Zhang, Yong-An Zhang, Yong-An Zhang, Yong-An Zhang, Xu-Jie Zhang, Xu-Jie Zhang, Xu-Jie Zhang   +12 more
doaj   +1 more source

CD5L promotes M2 macrophage polarization through autophagy-mediated upregulation of ID3 [PDF]

, 2018
CD5L (CD5 molecule-like) is a secreted glycoprotein that controls key mechanisms in inflammatory responses, with involvement in processes such as infection, atherosclerosis, and cancer.
Amézaga, Núria, Aran, Gemma, Armengol, Carolina, López Codina, Daniel, Prats Soler, Clara, Sanjurjo, Lucía, Sarrias, Maria Rosa, Téllez, Érica   +7 more
core   +2 more sources

Increased CD86 but Not CD80 and PD-L1 Expression on Liver CD68+ Cells during Chronic HBV Infection. [PDF]

PLoS ONE, 2016
The failure to establish potent anti-HBV T cell responses suggests the absence of an effective innate immune activation. Kupffer cells and liver-infiltrating monocytes/macrophages have an essential role in establishing anti-HBV responses.
Elias A Said, Iman Al-Reesi, Marwa Al-Riyami, Khalid Al-Naamani, Shadia Al-Sinawi, Mohammed S Al-Balushi, Crystal Y Koh, Juma Z Al-Busaidi, Mohamed A Idris, Ali A Al-Jabri   +9 more
doaj   +1 more source

Immunologic Significance of CD80/CD86 or Major Histocompatibility Complex-II Expression in Thymic Epithelial Tumors

JTO Clinical and Research Reports, 2023
Introduction: Unresectable or recurrent thymic epithelial tumors (TETs) have a poor prognosis, and treatment options are limited. This study aimed to investigate the immunologic significance of CD80/CD86 or major histocompatibility complex class II (MHC ...
Hideki Ikeda, MD, Joji Nagasaki, MD, PhD, Daiki Shimizu, MD, Yuki Katsuya, MD, PhD, Hidehito Horinouchi, MD, PhD, Yukio Hosomi, MD, PhD, Etsuko Tanji, MS, Takekazu Iwata, MD, PhD, Makiko Itami, MD, PhD, Masahito Kawazu, MD, PhD, Yuichiro Ohe, MD, PhD, Takuji Suzuki, MD, PhD, Yosuke Togashi, MD, PhD   +12 more
doaj   +1 more source

A non-conserved amino acid variant regulates differential signalling between human and mouse CD28 [PDF]

, 2018
CD28 superagonistic antibodies (CD28SAb) can preferentially activate and expand immunosuppressive regulatory T cells (Treg) in mice. However, pre-clinical trials assessing CD28SAbs for the therapy of autoimmune diseases reveal severe systemic ...
Alarcon, Balbino, Borroto, Aldo, Campese, Antonio F., Caristi, Silvana, Favre, Cédric, Grazioli, Paola, Kunkl, Martina, Mastrogiovanni, Marta, Muscolini, Michela, Nunès, Jacques A., Porciello, Nicla, Screpanti, Isabella, Spadaro, Francesca, Tuosto, Loretta   +13 more
core   +5 more sources

CD80/CD86 Costimulation Regulates Acute Vascular Rejection [PDF]

The Journal of Immunology, 2005
Abstract Xenotransplantation may provide the only solution to the shortage of human donor organs. Although hyperacute rejection associated with xenotransplantation can now be overcome, acute vascular rejection (AVR) remains a primary barrier to xenotransplantation.
Karoline A, Hosiawa, Hao, Wang, Mark E, DeVries, Bertha, Garcia, Weihua, Liu, Dejun, Zhou, Ali, Akram, Jifu, Jiang, Hongtao, Sun, Mark J, Cameron, Robert, Zhong, David J, Kelvin   +11 more
openaire   +2 more sources