Results 11 to 20 of about 16,236 (209)
Targeting CD83 in mantle cell lymphoma with anti‐human CD83 antibody [PDF]
Clinical & Translational Immunology, 2020 Objectives Effective antibody–drug conjugates (ADCs) provide potent targeted cancer therapies. CD83 is expressed on activated immune cells including B cells and is a therapeutic target for Hodgkin lymphoma.
Ziduo Li +11 more
doaj +4 more sources
The CD83 Molecule – An Important Immune Checkpoint
Frontiers in Immunology, 2020 The CD83 molecule has been identified to be expressed on numerous activated immune cells, including B and T lymphocytes, monocytes, dendritic cells, microglia, and neutrophils.
Linda Grosche +9 more
doaj +3 more sources
Human Decidua Contains Potent Immunostimulatory CD83+ Dendritic Cells [PDF]
The American Journal of Pathology, 2000 Dendritic cells (DCs) are sentinel cells of the immune system important in initiating antigen-specific T-cell responses to microbial and transplantation antigens. DCs are particularly found in surface tissues such as skin and mucosa, where the organism is threatened by infectious agents.
Ulrike Kämmerer +6 more
openalex +4 more sources
Inhibition of Cd83 Cell Surface Expression during Dendritic Cell Maturation by Interference with Nuclear Export of Cd83 mRNA [PDF]
The Journal of Experimental Medicine, 2000 Dendritic cells (DCs), nature's adjuvant, must mature to sensitize T cells. However, although the maturation process is essential, it is not yet fully understood at the molecular level. In this study, we investigated the course of expression of the unique hypusine-containing protein eukaryotic initiation factor 5A (eIF-5A), which is part of a ...
Monika Kruse +7 more
openalex +4 more sources
Haematologica, 2018 The development of combined chemotherapy with or without radiotherapy for classical Hodgkin lymphoma (HL) can be considered as a major success story in onocology. With current treatment protocols, a long-term cure is obtained in about 80-90% of patients.[1][1] However, these therapies come ...
Ralf Küppers
doaj +4 more sources
CD83 Expression in CD4+ T Cells Modulates Inflammation and Autoimmunity [PDF]
The Journal of Immunology, 2008 Abstract The transmembrane protein CD83 has been initially described as a maturation marker for dendritic cells. Moreover, there is increasing evidence that CD83 also regulates B cell function, thymic T cell maturation, and peripheral T cell activation.
Simone Reinwald +8 more
openalex +4 more sources
High Concentrations of β<sub>2</sub>-Microglobulin Do Not Inhibit In Vitro Generation of Functional Dendritic Cells. [PDF]
J Immunol Resβ2‐microglobulin (β2M) is a small protein playing a critical role in stabilizing major histocompatibility complex class I (MHC‐I) molecules on nucleated cells. Elevated levels of β2M have been observed in several cancers, inflammatory and autoimmune conditions, and renal failures.
Taborska P +4 more
europepmc +2 more sources
Decoding innate lymphoid cell heterogeneity and plasticity in colorectal cancer. [PDF]
Clin Transl MedThis schematic outlines the origin, heterogeneity, and plasticity of ILCs in colorectal cancer. Created in BioRender. Yiyi, X. (2026) https://BioRender.com/0kwrvq7. Abstract Background In colorectal cancer (CRC), innate lymphoid cells (ILCs) play a vital role in preserving and modulating immune homeostasis within the intestinal environment.
Zhang S +11 more
europepmc +2 more sources
The role of CD83: Autoimmunity, transplantation and beyond [PDF]
Research Outreach, 2020 openalex +2 more sources