Results 51 to 60 of about 16,236 (209)

A sustained decrease in serum CD83 in pregnant women

Journal of Reproductive Immunology, 2022
Maternal immunity regulates tolerance to the semi-allogeneic fetus during pregnancy via modulation of immune regulatory factors. The serum factor CD83 is known to undergo changes during gestation in mice. Here we characterize serum levels of CD83 in women for the first time, revealing a consistent decline as pregnancy progresses and recovery to non ...
Kameliya Vinketova, Vesselina Koleva, Elena Puncheva, Suzana Nashar, Tsvetelina Oreshkova   +4 more
openaire   +2 more sources

The role of CD83 in the pathogenesis of immune thrombocytopenia

Hematology
Background CD83 are closely related to the pathogenesis of immune thrombocytopenia (ITP), but the exact mechanism remains unclear.Aim To explore the relationship between CD83 and CD4+ T cell subsets and clarify the role of CD83 in the pathogenesis of ITP.
Xiuli Wang, Qiyuan Zhou, Wen Yang, Hui Bi, Honghui Wang, Yacan Wang, Yadong Du, Lin Liu, Yuebo Liu, Liefen Yin, Jin Yao, Jingxing Yu, Wei Tao, Yongchun Zhou, Zeping Zhou   +14 more
doaj   +1 more source

Microsatellite unstable colorectal cancers are associated with increased CD1a- and CD83-positive dendritic cell infiltration

Biotechnology & Biotechnological Equipment, 2023
Microsatellite instability (MSI) is characterized by a highly immunogenic tumor phenotype and abundant lymphocytic infiltrates. The aim of this study was to investigate the association between four immunohistochemically determined classes of dendritic ...
Maya Gulubova, Elina Aleksandrova, Yovcho Yovchev, Dimitar Chonov, Petio Chilingirov, Tatyana Vlaykova   +5 more
doaj   +1 more source

Unique Features and Distribution of the Chicken CD83+ Cell [PDF]

The Journal of Immunology, 2007
Abstract The central importance of dendritic cells (DC) in both innate and acquired immunity is well recognized in the mammalian immune system. By contrast DC have yet to be characterized in avian species despite the fact that avian species such as the chicken have a well-developed immune system. CD83 has proven to be an excellent marker
Chris, Hansell, Xing Wu, Zhu, Heather, Brooks, Mark, Sheppard, Sam, Withanage, Duncan, Maskell, Ian, McConnell   +6 more
openaire   +2 more sources

CD83: Activation Marker for Antigen Presenting Cells and Its Therapeutic Potential

Frontiers in Immunology, 2019
CD83 is a member of the immunoglobulin (Ig) superfamily and is expressed in membrane bound or soluble forms. Membrane CD83 (mCD83) can be detected on a variety of activated immune cells, although it is most highly and stably expressed by mature dendritic
Ziduo Li, Ziduo Li, Xinsheng Ju, Xinsheng Ju, Pablo A. Silveira, Pablo A. Silveira, Edward Abadir, Edward Abadir, Wei-Hsun Hsu, Wei-Hsun Hsu, Derek N. J. Hart, Derek N. J. Hart, Georgina J. Clark, Georgina J. Clark   +13 more
doaj   +1 more source

The expression and characterization of functionally active soluble CD83 by Pichia pastoris using high-density fermentation.

PLoS ONE, 2014
CD83 is a highly glycosylated type I transmembrane glycoprotein that belongs to the immunoglobulin superfamily. CD83 is upregulated during dendritic cell (DC) maturation, which is critical for the initiation of adaptive immune responses.
Yugang Guo, Rui Li, Xiaoping Song, Yongjun Zhong, Chenguang Wang, Hao Jia, Lidan Wu, Dong Wang, Fang Fang, Jiajia Ma, Wenyao Kang, Jie Sun, Zhigang Tian, Weihua Xiao   +13 more
doaj   +1 more source

Dendritic cell CD83: A therapeutic target or innocent bystander? [PDF]

Immunology Letters, 2008
CD83 represents an intriguing target for immunotherapy due to its preferential expression on mature DCs, the most efficient of antigen presenting cells. Based on its restricted expression pattern, structure, and the paucity of CD4+ T cells in CD83-deficient mice, multiple immunologically important functions for CD83 during immune responses have been ...
Charlene M, Prazma, Thomas F, Tedder
openaire   +2 more sources

Bioengineered Pancreatic Cancer Immunosuppressive Microenvironment Models for Screening Immunotherapies

Advanced Healthcare Materials, EarlyView.
Bioengineering tumor‐stroma pancreatic cancer models with potential to emulate the native immunosuppressive tumor microenvironment. Cancer‐on‐a‐bead models exhibited higher relevance for screening immunotherapies and modulating the protumoral PDAC microenvironment. ABSTRACT Pancreatic cancer is notably resistant to treatment, primarily due to its dense
Maria V. Monteiro, Margarida Henriques‐Pereira, Bruno M. Neves, Vítor M. Gaspar, João F. Mano   +4 more
wiley   +1 more source

Single‐Cell Profiling Across Immune Tissues and Organs Reveals Immunosenescence Signatures in Male Rhesus Monkeys

Advanced Science, EarlyView.
Single‐cell profiling across bone marrow, spleen, mesenteric lymph, and blood in rhesus monkeys reveals organ Immunosenescence. GZMB rises with age, particularly in cytotoxic and terminally exhausted CD8+ T cells, and BHLHE40 emerges as a key transcription factor enriched across multiple CD8+ subsets, regulating pro‐inflammatory and exhaustion‐related ...
Shengnan Wang, Zhengna Zhu, Hongju Yang, Yaping Yan, Luyao Ran, Naixue Yang, Yichao Wang, Li Wu, Bing Bai, Weizhi Ji, Wei Si   +10 more
wiley   +1 more source

Pregnancy-related factors induce immune tolerance through regulation of sCD83 release

Frontiers in Immunology
A well-balanced maternal immune system is crucial to maintain fetal tolerance in case of infections during pregnancy. Immune adaptations include an increased secretion of soluble mediators to protect the semi-allogeneic fetus from excessive pro ...
Pauline Krupa, Hannah Wein, Lea Sophie Zemmrich, Marek Zygmunt, Damián Oscar Muzzio   +4 more
doaj   +1 more source