Results 61 to 70 of about 14,542 (144)

Inflammatory cell expression of Toll-like receptor-2 (TLR2) within refractory periapical granuloma. [version 1; referees: 2 approved]

F1000Research, 2018
Background: Toll-like receptor-2 (TLR2) is highly important within the immune system. Characterization of the expression of TLR2 within inflammatory cells in periapical lesions could help in diagnosis and management of refractory cases.
Eric Chen, Mahmoud M. Bakr, Norman Firth, Robert M. Love   +3 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, Volume 20, Issue 3, Page 753-778, March 2026.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Nanoparticle Immunoadjuvant Complexes Augment Germinal Center Responses to Vaccination

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Scaffolding IL‐21 on the surface of a self‐assembling nanoparticle immunogen drives improved germinal center and humoral immune responses. These nanoparticle immunoadjuvant complexes (NICs) functionally modulate the germinal center driving improved somatic hypermutation and antibody maturation, suggesting this platform has potential utility as a ...
Nicholas J. Tursi, Colby J. Agostino, Jinwei Huang, Toshitha Kannan, Niklas Laenger, Jennifer Londregan, Katlyn Lederer, Michaela Helble, Nicole Bedanova, Cory Livingston, Ebony N. Gary, Madison McCanna, Marta Tarquis Medina, Rumi Habib, Ignacio Rodriguez Relaño, Ivan Maillard, Ami Patel, David Allman, Andrew Kossenkov, Amelia Escolano, Daniel W. Kulp, David. B. Weiner   +21 more
wiley   +1 more source

Neutrophils in Atlantic salmon (Salmo salar L.) are MHC class II+ and secret IL-12p40 upon bacterial exposure

Aquaculture and Fisheries
Antigen-presentation via major histocompatibility complex (MHC) to T cells is the key event to initiate adaptive immune responses. In teleosts, as in mammals, the main types of professional antigen-presenting cells (APCs) are dendritic cells (DCs ...
Gyri Teien Haugland, Anita Rønneseth, Lene Gundersen, Harald Sæbø Lunde, Kaja Nordland, Heidrun Inger Wergeland   +5 more
doaj   +1 more source

Efficient Maturation and Cytokine Production of Neonatal DCs Requires Combined Proinflammatory Signals

Clinical and Developmental Immunology, 2005
Specific functional properties of dendritic cells (DCs) have been suspected as being responsible for the impaired specific immune responses observed in human neonates.
Doreen Krumbiegel, Jan Rohr, Peter Schmidtke, Markus Knuf, Fred Zepp, Claudius U. Meyer   +5 more
doaj   +1 more source

Dendritic cells matured with recombinant human sperm associated antigen 9 (rhSPAG9) induce CD4+, CD8+ T cells and activate NK cells: a potential candidate molecule for immunotherapy in cervical cancer

Cancer Cell International, 2021
Background Dendritic cell (DC)-based immunotherapy is capable of activating the immune system and in particular tumor-specific cytotoxic T lymphocytes (CTLs) to eradicate the tumor.
Hemavathi Dhandapani, Hascitha Jayakumar, Abirami Seetharaman, Shirley Sunder Singh, Selvaluxmy Ganeshrajah, Nirmala Jagadish, Anil Suri, Rajkumar Thangarajan, Priya Ramanathan   +8 more
doaj   +1 more source

Senescent Synovial Intimal Fibroblasts Aggravate Osteoarthritis by Regulating Macrophage Polarization and Chondrocyte Phenotype Through ANGPTL4‐α5β1 Axis

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Senescent synovial intimal fibroblasts (SIF) are identified as key drivers of osteoarthritis. They promote M1 macrophage polarization and cartilage degeneration via the ANGPTL4–α5β1 axis, regulated by transcription factors EGR1 and ATF3. Pharmacological inhibition of this pathway alleviates disease, revealing SIF senescence as a promising therapeutic ...
Muhai Deng, Yunsheng Jiang, Zhiyu Chen, Kaiquan Chen, Na Cao, Yang Huang, Zhengxue Quan, Cheng Chen   +7 more
wiley   +1 more source

Leukemia-derived exosomes induce immunosuppression of dendritic cell function via TGFB2-MRPL58 axis

Hematology
Objectives To elucidate the mechanisms by which leukemia-derived exosomes induce immunosuppression in dendritic cells (DCs) and identify potential therapeutic targets.Methods The optimal exosome dosage (20 µg/ml) for DC treatment was determined via ...
Jinglong Lv, Yang Tao, Hui Zhong, Xiaohong Xie, Hongxia Chen, Zhudan Hou, Wenfang Luo, Yangjun Liu, Rui Huang   +8 more
doaj   +1 more source

Rutaceae Zanthoxylum–Derived 7‐Demethylsuberosin Alleviates the Rheumatoid Arthritis Through Inhibiting the Maturation of Dendritic Cells via Targeting MAPK14 Functional Food‐Based 7‐Demethylsuberosin

Food Frontiers, Volume 7, Issue 2, March 2026.
This study revealed that 7‐demethylsuberosin exhibits immunosuppressive effects both in vivo and in vitro. Furthermore, it inhibits the phosphorylation of MAPK14 by targeting it, thereby modulating dendritic cell (DC) maturation and function and reducing inflammation across various in vivo models.
Peng Han, Bo Wang, Luyang Han, Yanbo Zhu, Jiawei Dong, Yuekang Xu, Xiaoying Liu, Jinyao Li   +7 more
wiley   +1 more source

Expression of chicken DEC205 reflects the unique structure and function of the avian immune system.

PLoS ONE, 2013
The generation of appropriate adaptive immune responses relies critically on dendritic cells, about which relatively little is known in chickens, a vital livestock species, in comparison with man and mouse. We cloned and sequenced chicken DEC205 cDNA and
Karen Staines, John R Young, Colin Butter   +2 more
doaj   +1 more source