Results 1 to 10 of about 378,585 (147)
The Scientific World Journal, 2012 As many members of the tumor necrosis factor receptor superfamily, glucocorticoid-induced TNFR-related gene (GITR) plays multiple roles mostly in the cells of immune system.
Simona Ronchetti +3 more
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CD8+ T Cells in Atherosclerosis [PDF]
Cells, 2020 Atherosclerotic lesions are populated by cells of the innate and adaptive immune system, including CD8+ T cells. The CD8+ T cell infiltrate has recently been characterized in mouse and human atherosclerosis and revealed activated, cytotoxic, and possibly
Sarah Schäfer, Alma Zernecke
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KIR+CD8+ and NKG2A+CD8+ T cells are distinct innate-like populations in humans
Cell Reports, 2023 Summary: Subsets of the human CD8+ T cell population express inhibitory NK cell receptors, such as killer immunoglobulin-like receptors (KIRs) and NKG2A.
Seong Jin Choi +7 more
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CD8+ T Cell Exhaustion in Cancer [PDF]
Frontiers in Immunology, 2021 A paradigm shift in the understanding of the exhausted CD8+ T cell (Tex) lineage is underway. Originally thought to be a uniform population that progressively loses effector function in response to persistent antigen, single-cell analysis has now revealed that CD8+ Tex is composed of multiple interconnected subpopulations.
Joseph S. Dolina +3 more
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Frontiers in Immunology, 2021 BackgroundThis study aimed to assess the host immune signatures associated with EBV infection and its clinical value in indicating the severity of children with acute infectious mononucleosis (IM).MethodsTwenty-eight pediatric patients with IM aged 3–8 ...
Yun Wang +14 more
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CD40 ligand stimulation affects the number and memory phenotypes of human peripheral CD8+ T cells
BMC Immunology, 2023 Background CD40L is primarily expressed on activated CD4+ T cells and binds to CD40 which is expressed by various cells including dendritic cells, macrophages and B lymphocytes.
Haeyoun Choi +3 more
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Frontiers in Immunology, 2021 The role of Ly49+CD8 T-cells in the immune system is not clear. Previously, several papers suggested Ly49+CD8 T-cells as immunosuppressors, while multiple studies also suggested their role as potent participants of the immune response.
Dmytro Shytikov +10 more
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CD8 T cell memory recall is enhanced by novel direct interactions with CD4 T cells enabled by MHC class II transferred from APCs. [PDF]
PLoS ONE, 2013 Protection against many intracellular pathogens is provided by CD8 T cells, which are thought to need CD4 T cell help to develop into effective memory CD8 T cells.
Pablo A Romagnoli +3 more
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Frontiers in Immunology, 2022 IntroductionIncreased CCL5 expression and CD8 T cells have been shown to be pivotal regulators of immunopathology in primary Sjögren’s syndrome (pSS) and pSS-like disease. Increased CCL5 expression by CCR9+ CD4 T cells has previously been implicated as a
Anneline C. Hinrichs +8 more
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CD8 T cell quiescence revisited [PDF]
Trends in Immunology, 2012 Naïve T cells are typically considered to be in a default state of quiescence, whereas memory T cells undergo basal proliferation and quickly exhibit effector responses when stimulated. Over the past few years, however, a more complex picture has emerged, with evidence that naïve T cell quiescence is actively enforced, and that heterogeneity among ...
Sara E, Hamilton, Stephen C, Jameson
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