Results 1 to 10 of about 6,241 (179)

Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression [PDF]

eLife
Atherosclerosis is characterized by lipid accumulation within plaques, leading to foam cell formation and an inflammatory response within the aortic lesions.
Tianhan Li, Liaoxun Lu, Juanjuan Qiu, Xin Dong, Le Yang, Kexin He, Yanrong Gu, Binhui Zhou, Tingting Jia, Toby Lawrence, Marie Malissen, Guixue Wang, Rong Huang, Hui Wang, Bernard Malissen, Yinming Liang, Lichen Zhang   +16 more
doaj   +2 more sources

Regnase-1 in cDC1 controls T cell priming and shapes the dynamics of experimental autoimmune encephalomyelitis [PDF]

Frontiers in Immunology
IntroductionMultiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system (CNS), in which various immune cells contribute to disease progression, yet the role of dendritic cells (DCs) remains incompletely understood ...
Xingyu Rong, Hai Wang, Shintaro Muraoka, Takuya Uehata, Masanori Yoshinaga, Tsuneyasu Kaisho, Osamu Takeuchi   +6 more
doaj   +2 more sources

Intratumoral delivery of FLT3L with CXCR3/CCR5 ligands promotes XCR1+ cDC1 infiltration and activates anti-tumor immunity [PDF]

Nature Communications
Tumor infiltration by XCR1⁺ conventional dendritic cells (cDC1) correlates strongly with favorable prognosis and improved responses to immunotherapy. Yet, tumor-driven immunosuppressive programs restrict efficient cDC1 recruitment, highlighting the need ...
Louise Gorline, Fillipe Luiz Rosa do Carmo, Pierre Bourdely, Jérémie Bornères, Nathan Vaudiau, Aurélie Semervil, Mathias Vetillard, Aboubacar Sidiki K Coulibaly, Natacha Jugniot, Agathe Ok, Mathilde Bausart, Oriane Fiquet, Marine Andrade, Dicken Fardol, Ikrame Haddar, Zeina Abou Nader, Judith Weber, Hannah Theobald, Matthieu Collin, Joseph Calmette, Giorgio Anselmi, Flavia Fico, Florent Ginhoux, Laleh Majlessi, Emmanuel L. Gautier, Loredana Saveanu, Julie Helft, Marc Dalod, Mathilde Dusseaux, James P. Di Santo, Stéphanie Hugues, Pierre Guermonprez   +31 more
doaj   +2 more sources

High Fat and Sugar Diet Increases Enteric cDC1 and Oral Antigen-Specific Tregs [PDF]

Journal of Immunology Research
Diet-induced obesity is a growing global health concern linked to various immunological alterations. Dendritic cells (DCs) are major regulators of the balance between pro-inflammatory and tolerogenic immune responses.
K. Fischer, O. Horno, B. Raposo, I. Godinho, H. Ribeiro, H. Veiga-Fernandes, M. Martínez-López   +6 more
doaj   +2 more sources

The 41BB-agonist potentiates the therapeutic efficacy of a combined irreversible electroporation ablation treatment of lung cancer by promoting unexpected CD8+CD103+ cDC1 and tissue-resident memory T cell responses [PDF]

Frontiers in Immunology
Irreversible electroporation (IRE) is a relatively new, non-thermal ablation technology for cancer treatment that requires further investigation to optimize its therapeutic efficacy.
Chen Fang, Chen Fang, Chen Fang, Zhaojia Wu, Zhaojia Wu, Scot C. Leary, Yiling Bai, Yiling Bai, Michelle Yu, Michelle Yu, Nicolas Baniak, Shahid Ahmed, Shahid Ahmed, Gary Groot, Michael Moser, Wenjun Zhang, Bing Zhang, Junqiong Huang, Haitao Ma, Yu Feng, Jim Xiang, Jim Xiang   +21 more
doaj   +2 more sources

Natural killer cells and dendritic epidermal γδ T cells orchestrate type 1 conventional DC spatiotemporal repositioning toward CD8+ T cells

iScience, 2021
Summary: Successful immune responses rely on a regulated delivery of the right signals to the right cells at the right time. Here we show that natural killer (NK) and dendritic epidermal γδ T cells (DETCs) use similar mechanisms to spatiotemporally ...
Sonia Ghilas, Marc Ambrosini, Jean-Charles Cancel, Carine Brousse, Marion Massé, Hugues Lelouard, Marc Dalod, Karine Crozat   +7 more
doaj   +1 more source

Conventional Type 1 Dendritic Cells in Intestinal Immune Homeostasis

Frontiers in Immunology, 2022
Dendritic cells (DC) play critical roles in linking innate and adaptive immunity. DC are heterogenous and there are subsets with various distinct functions.
Izumi Sasaki, Takashi Kato, Hiroaki Hemmi, Hiroaki Hemmi, Yuri Fukuda-Ohta, Naoko Wakaki-Nishiyama, Asumi Yamamoto, Tsuneyasu Kaisho   +7 more
doaj   +1 more source

Absence of Batf3 reveals a new dimension of cell state heterogeneity within conventional dendritic cells

iScience, 2021
Summary: Conventional dendritic cells (cDCs) are traditionally subdivided into cDC1 and cDC2 lineages. Batf3 is a cDC1-required transcription factor, and we observed that Batf3−/− mice harbor a population of cDC1-like cells co-expressing cDC2-associated ...
Samuel W. Lukowski, Inga Rødahl, Samuel Kelly, Meihua Yu, James Gotley, Chenhao Zhou, Susan Millard, Stacey B. Andersen, Angelika N. Christ, Gabrielle Belz, Ian H. Frazer, Janin Chandra   +11 more
doaj   +1 more source

Single cell RNA sequencing reveals distinct clusters of Irf8-expressing pulmonary conventional dendritic cells

Frontiers in Immunology, 2023
A single population of interferon-regulatory factor 8 (Irf8)-dependent conventional dendritic cell (cDC type1) is considered to be responsible for both immunogenic and tolerogenic responses depending on the surrounding cytokine milieu. Here, we challenge
Adan Chari Jirmo, Adan Chari Jirmo, Ruth Grychtol, Ruth Grychtol, Svenja Gaedcke, Bin Liu, Stephanie DeStefano, Christine Happle, Christine Happle, Olga Halle, Olga Halle, Joao T. Monteiro, Joao T. Monteiro, Anika Habener, Anika Habener, Oliver D. Breiholz, David DeLuca, Gesine Hansen, Gesine Hansen, Gesine Hansen   +19 more
doaj   +1 more source

Enhancing the immunogenicity of cancer vaccines by harnessing CLEC9A

Human Vaccines & Immunotherapeutics, 2022
Dendritic cell (DC) vaccines are a safe and effective means of inducing tumor immune responses, however, a better understanding of DC biology is required in order to realize their full potential.
M. H. Lahoud, K. J. Radford
doaj   +1 more source