Results 111 to 120 of about 6,241 (179)

Inflammatory niches as spatial drivers of disease mechanisms and targets for personalized treatment

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 3, Page 423-430, March 2026.
This study provides a comprehensive review of how spatial transcriptomics reveals disease‐specific inflammatory niches across multiple skin disorders, highlighting key immune–stromal, neuro–immune and metabolic interactions that were previously unappreciated in non‐spatial analyses. Abstract Disease states are increasingly recognized as being shaped by
Rundong Jiang, Zhiqin Fang, Lam C. Tsoi, Johann E. Gudjonsson   +3 more
wiley   +1 more source

Intestinal cDC1s provide cues required for CD4+ T cell–mediated resistance to Cryptosporidium

Journal of Experimental Medicine
Cryptosporidium is an enteric pathogen and a prominent cause of diarrheal disease worldwide. Control of Cryptosporidium requires CD4+ T cells, but how protective CD4+ T cell responses are generated is poorly understood. Here, Cryptosporidium parasites that express MHCII-restricted model antigens were generated to understand the basis for CD4+ T cell ...
Ian S. Cohn, Bethan A. Wallbank, Breanne E. Haskins, Keenan M. O’Dea, Ryan D. Pardy, Sebastian Shaw, Maria I. Merolle, Jodi A. Gullicksrud, David A. Christian, Boris Striepen, Christopher A. Hunter   +10 more
openaire   +2 more sources

FcRn regulates antigen presentation in dendritic cells downstream of DEC205-targeted vaccines

npj Vaccines
Dendritic cell (DC)-targeted vaccination is a new mode of antigen delivery that relies on the use of monoclonal antibodies (mAb) to target antigen to specific DC subsets.
Christophe Macri, Matthew Paxman, Devi Jenika, Xiao Peng Lin, Zahra Elahi, Paul A. Gleeson, Irina Caminschi, Mireille H. Lahoud, Jose A. Villadangos, Justine D. Mintern   +9 more
doaj   +1 more source

Granulocyte-macrophage colony-stimulating factor may contribute to spondyloarthritis development in HLA-B27 transgenic rat by affecting conventional dendritic cells function

Arthritis Research & Therapy
Background Spondyloarthritis (SpA) is a chronic inflammatory disorder with axial and peripheral manifestations. A strong association between HLA-B27 and SpA has been known for more than 50 years.
Amel Ait Ali Said, Chiara Rizzo, Hendrick Mambu Mambueni, Félicie Costantino, Maxime Breban, Simon Glatigny   +5 more
doaj   +1 more source

Development and migration of cDC1 in the spleen

Precursor of dendritic cells (preDCs) develop in the bone marrow and continuously seed in tissues where preDCs further differentiate and migrate to and within secondary lymphoid organs to orchestrate adaptive immunity. Where preDCs seed the splenic red pulp, locally develop into type 1 conventional dendritic cells (cDC1s) and migrate to the white pulp ...
openaire   +2 more sources

1143 cDC1 engagement induces Th1 differentiation and tumor regression in vivo

Regular and Young Investigator Award Abstracts, 2023
Qi Hao, Meng Sun, Yue Liu, Jonathan Powell, Fiona Harding, Janani Sridar, Marcia Stickler, Seonhui Shim, Maria Pokrovskii, Kenneth Finn, Marc Creixell, Chirag Partel, Clint Remarcik   +12 more
openaire   +2 more sources

Enhancing immunogenic cell death by targeting the GPX4-ZP3 immune checkpoint. [PDF]

Oncoimmunology
Tang D, Kang R, Liu P, Kroemer G.
europepmc   +1 more source

Chemoradiation of glioblastoma cells alters expression of activation and immune checkpoint molecules on type 1 and 2 dendritic cells and impacts on subsequent T cell proliferation. [PDF]

Clin Transl Radiat Oncol
Schuster C, Frey B, Fietkau R, Corradini S, Gaipl US, Derer A.   +5 more
europepmc   +1 more source

NK cell-mediated tumor cell killing by bispecific innate cell engagers induces ADCC-mediated activation of primary human dendritic cells. [PDF]

Oncoimmunology
Heger L, Kaszubowski T, Amon L, Lehmann CHK, Wingert S, Medina-Echeverz J, Koch J, Hackstein H, Purbojo A, Hartmann A, Alexiou C, Cesnjevar R, Pahl J, Dudziak D.   +13 more
europepmc   +1 more source

Type 1 and CD103⁺ Type 2 Conventional Dendritic Cells Are Decreased in Active Patients with Ulcerative Colitis but Not with Crohn's Disease. [PDF]

Eur J Immunol
Arribas-Rodríguez E, de Castro CG, Fiz-López A, De Prado Á, Martín-Muñoz Á, Fernández Salazar L, Barrio J, Izquierdo S, García Alonso J, de Andrés B, García-Abril JM, Romero A, Sánchez González J, Santander C, Arranz E, Chaparro M, Garrote JA, Gisbert JP, Bernardo D.   +18 more
europepmc   +1 more source