Results 11 to 20 of about 6,241 (179)

Conventional type 1 dendritic cells (cDC1) in cancer immunity

Biology Direct, 2023
Cancer immunotherapy, alone or in combination with conventional therapies, has revolutionized the landscape of antineoplastic treatments, with dendritic cells (DC) emerging as key orchestrators of anti-tumor immune responses.
Peng Liu, Liwei Zhao, Guido Kroemer, Oliver Kepp   +3 more
doaj   +4 more sources

The role of cDC1s in vivo: CD8 T cell priming through cross-presentation [version 1; referees: 3 approved] [PDF]

F1000Research, 2017
The cDC1 subset of classical dendritic cells is specialized for priming CD8 T cell responses through the process of cross-presentation. The molecular mechanisms of cross-presentation remain incompletely understood because of limited biochemical analysis ...
Derek Theisen, Kenneth Murphy
doaj   +3 more sources

cDC1 dysregulation in cancer: An opportunity for intervention [PDF]

Journal of Experimental Medicine, 2020
Conventional dendritic cells driven by the transcription factor Batf3 (cDC1 cells) are critical for the activation and maintenance of tumor-specific CD8+ T cells. In this issue of JEM, Lin et al. (https://doi.org/10.1084/jem.20190673) demonstrate systemic dysfunction of cDC1 cells in pancreatic cancer, which offers potential treatment strategies to ...
Thomas F. Gajewski, Kyle R. Cron
openaire   +2 more sources

Type 1 conventional dendritic cells and interferons are required for spontaneous CD4+ and CD8+ T‐cell protective responses to breast cancer

Clinical & Translational Immunology, 2021
Objectives To better understand how immune responses may be harnessed against breast cancer, we investigated which immune cell types and signalling pathways are required for spontaneous control of a mouse model of mammary adenocarcinoma.
Raphaël Mattiuz, Carine Brousse, Marc Ambrosini, Jean‐Charles Cancel, Gilles Bessou, Julie Mussard, Amélien Sanlaville, Christophe Caux, Nathalie Bendriss‐Vermare, Jenny Valladeau‐Guilemond, Marc Dalod, Karine Crozat   +11 more
doaj   +1 more source

STAT3 Inhibits CD103+ cDC1 Vaccine Efficacy in Murine Breast Cancer [PDF]

Cancers, 2020
Conventional dendritic cells (cDCs) are a critical immune population, composed of multiple subsets, and responsible for controlling adaptive immunity and tolerance. Although migratory type 1 cDCs (CD103+ cDC1s in mice) are necessary to mount CD8+ T cell-mediated anti-tumor immunity, whether and how tumors modulate CD103+ cDC1 function remain ...
Taylor T. Chrisikos, Yifan Zhou, Haiyan S. Li, Rachel L. Babcock, Xianxiu Wan, Bhakti Patel, Kathryn Newton, James J. Mancuso, Stephanie S. Watowich   +8 more
openaire   +2 more sources

Priority lane to cDC1 open for IRF8+ progenitors [PDF]

Blood, 2019
In this issue of Blood , Kurotaki et al demonstrate that IRF8 expression delineates a subset of lymphoid-primed multipotent progenitors (LMPPs) biased toward the generation of conventional type 1 dendritic cells (cDC1s) by epigenetically priming the precursors for the expression of dendritic cell (DC) lineage genes ...
Martin Guilliams, Charlotte L. Scott
openaire   +2 more sources

The transcription factor Zeb1 controls homeostasis and function of type 1 conventional dendritic cells

Nature Communications, 2023
Type 1 conventional dendritic cells (cDC1) are the most efficient cross-presenting cells that induce protective cytotoxic T cell response. However, the regulation of their homeostasis and function is incompletely understood.
Yan Wang, Quan Zhang, Tingting He, Yechen Wang, Tianqi Lu, Zengge Wang, Yiyi Wang, Shen Lin, Kang Yang, Xinming Wang, Jun Xie, Ying Zhou, Yazhen Hong, Wen-Hsien Liu, Kairui Mao, Shih-Chin Cheng, Xin Chen, Qiyuan Li, Nengming Xiao   +18 more
doaj   +1 more source

STAT3 signaling modulates the immune response induced after antigen targeting to conventional type 1 dendritic cells through the DEC205 receptor

Frontiers in Immunology, 2022
Conventional dendritic cells (cDC) are a group of antigen-presenting cells specialized in priming T cell responses. In mice, splenic cDC are divided into conventional type 1 DC (cDC1) and conventional type 2 (cDC2).
Fernando Bandeira Sulczewski, Larissa Alves Martino, Davi Salles, Márcio Massao Yamamoto, Daniela Santoro Rosa, Daniela Santoro Rosa, Silvia Beatriz Boscardin, Silvia Beatriz Boscardin   +7 more
doaj   +1 more source

IL-6 selectively suppresses cDC1 specification via C/EBPβ

Journal of Experimental Medicine, 2023
Cytokines produced in association with tumors can impair antitumor immune responses by reducing the abundance of type 1 conventional dendritic cells (cDC1), but the mechanism remains unclear. Here, we show that tumor-derived IL-6 generally reduces cDC development but selectively impairs cDC1 development in both murine and human systems through the ...
Sunkyung Kim, Jing Chen, Suin Jo, Feiya Ou, Stephen T. Ferris, Tian-Tian Liu, Ray A. Ohara, David A. Anderson, Renee Wu, Michael Y. Chen, William E. Gillanders, William E. Gillanders, Theresa L. Murphy, Kenneth M. Murphy   +13 more
openaire   +3 more sources

Sterile liver injury induces a protective tissue-resident cDC1-ILC1 circuit through cDC1-intrinsic cGAS-STING-dependent IL-12 production

Cell Reports, 2023
Tissue-resident immune cells are critical to the initiation and potentiation of inflammation. However, the tissue-protective cellular communication networks initiated by resident immunity during sterile inflammation are not well understood. Using single-cell transcriptomic analysis, we show the liver-resident cell connectome and signalome during acute ...
Andrew D. Hildreth, Eddie T. Padilla, Rana Yakhshi Tafti, Akshara R. Legala, Timothy E. O’Sullivan   +4 more
openaire   +5 more sources