Results 31 to 40 of about 6,241 (179)

Human cDC1s display constitutive activation of the UPR sensor IRE1

European Journal of Immunology, 2022
AbstractThe intracellular mechanisms safeguarding DC function are of biomedical interest in several immune‐related diseases. Type 1 conventional DCs (cDC1s) are prominent targets of immunotherapy typified by constitutive activation of the unfolded protein response (UPR) sensor IRE1.
Paulina García‐González, Dominique Fernández, Diane Gutiérrez, Mauro Parra‐Cordero, Fabiola Osorio   +4 more
openaire   +3 more sources

Longitudinal analysis of DC subsets in patients with ovarian cancer: Implications for immunotherapy

Frontiers in Immunology, 2023
BackgroundThe use of circulating cDC1 to generate anti-cancer vaccines is among the most promising approaches to overcome the limited immunogenicity and clinical efficacy of monocyte-derived DC.
Beatris Mastelic-Gavillet, Beatris Mastelic-Gavillet, Apostolos Sarivalasis, Leyder Elena Lozano, Leyder Elena Lozano, Sebastien Lofek, Sebastien Lofek, Tania Wyss, Tania Wyss, Tania Wyss, Ignacio Melero, Ignacio Melero, Ignacio Melero, Ignacio Melero, I. Jolanda M. de Vries, Alexandre Harari, Alexandre Harari, Pedro Romero, Pedro Romero, Lana Elias Kandalaft, Lana Elias Kandalaft, Selena Viganó, Selena Viganó   +22 more
doaj   +1 more source

Beyond cDC1: Emerging Roles of DC Crosstalk in Cancer Immunity [PDF]

Frontiers in Immunology, 2019
Dendritic cells (DCs) efficiently process and present antigens to T cells, and by integrating environmental signals, link innate and adaptive immunity. DCs also control the balance between tolerance and immunity, and are required for T-cell mediated anti-tumor immunity.
Rajkumar Noubade, Sonia Majri-Morrison, Kristin V. Tarbell   +2 more
openaire   +3 more sources

T cell infiltration on local CpG-B delivery in early-stage melanoma is predominantly related to CLEC9A+CD141+ cDC1 and CD14+ antigen-presenting cell recruitment

Journal for ImmunoTherapy of Cancer, 2021
Background We previously reported CpG-B injection at the primary tumor excision site prior to re-excision and sentinel node biopsy to result in immune activation of the sentinel lymph node (SLN), increased melanoma-specific CD8+ T cell rates in ...
Tanja D de Gruijl, M Petrousjka van den Tol, Bas D Koster, Rik J Scheper, Barbara G Molenkamp, Alfons JM van den Eertwegh, Mari FCM van den Hout, Berbel JR Sluijter, Paul AM van Leeuwen, Marta López González, Annelies W Turksma, Saskia Vosslamber, Ekaterina J Jordanova   +12 more
doaj   +1 more source

Conventional Type 1 Dendritic Cells (cDC1) in Human Kidney Diseases: Clinico-Pathological Correlations [PDF]

Frontiers in Immunology, 2021
BackgroundcDC1 is a subset of conventional DCs, whose most recognized function is cross-presentation to CD8+ T cells. We conducted this study to investigate the number and location of cDC1s in various human kidney diseases as well as their correlation with clinico-pathological features and CD8+ T cells.MethodsWe analyzed 135 kidney biopsies samples ...
Titi Chen, Titi Chen, Titi Chen, Qi Cao, Qi Cao, Ruifeng Wang, Guoping Zheng, Guoping Zheng, Farhana Azmi, Farhana Azmi, Jeffery Wang, Jeffery Wang, Vincent W. Lee, Vincent W. Lee, Vincent W. Lee, Yuan Min Wang, Hong Yu, Manish Patel, Manish Patel, Chow Heok P’ng, Stephen I. Alexander, Natasha M. Rogers, Natasha M. Rogers, Natasha M. Rogers, Yiping Wang, Yiping Wang, David C. H. Harris, David C. H. Harris, David C. H. Harris   +28 more
openaire   +3 more sources

cDC1 are required for the initiation of collagen-induced arthritis

Journal of Translational Autoimmunity, 2020
Rheumatoid arthritis (RA) is chronic autoimmune disease which etiology remains unknown. Several cell types have been described to potentiate/aggravate the arthritic process however the initiating event in synovial inflammation is still elusive. Dendritic cells (DCs) are essential for the initiation of primary immune responses and thus we hypothesized ...
Ramos, Maria Ines, Garcia, Samuel, Helder, Boy, Aarrass, Saida, Reedquist, Kris A., Jacobsen, Sten E., Tak, Paul, Lebre, Maria Cristina   +7 more
openaire   +4 more sources

Cryptic activation of an Irf8 enhancer governs cDC1 fate specification [PDF]

Nature Immunology, 2019
Induction of the transcription factor Irf8 in the common dendritic cell progenitor (CDP) is required for classical type 1 dendritic cell (cDC1) fate specification, but the mechanisms controlling this induction are unclear. In the present study Irf8 enhancers were identified via chromatin profiling of dendritic cells and CRISPR/Cas9 genome editing was ...
Vivek Durai, Prachi Bagadia, Jeffrey M. Granja, Ansuman T. Satpathy, Devesha H. Kulkarni, Jesse T. Davidson, Renee Wu, Swapneel J. Patel, Arifumi Iwata, Tian-Tian Liu, Xiao Huang, Carlos G. Briseño, Gary E. Grajales-Reyes, Miriam Wöhner, Hiromi Tagoh, Barbara L. Kee, Rodney D. Newberry, Meinrad Busslinger, Howard Y. Chang, Theresa L. Murphy, Kenneth M. Murphy   +20 more
openaire   +2 more sources

ALCAM-mediated cDC1 CD8 T cells interactions are suppressed in advanced lung tumors

OncoImmunology
Conventional type 1 dendritic cells (cDC1) are critical regulators of anti-tumoral T-cell responses. The structure and abundance of intercellular contacts between cDC1 and CD8 T cells in cancer tissues is important to determine the outcome of the T-cell ...
Luciano G. Morosi, Giulia M. Piperno, Lucía López, Roberto Amadio, Sonal Joshi, Alessandra Rustighi, Giannino Del Sal, Federica Benvenuti   +7 more
doaj   +1 more source

Conventional type 2 lung dendritic cells are potent inducers of follicular helper T cells in the asthmatic lung

Allergology International, 2021
Background: Follicular helper T (Tfh) cells represent a unique subset of helper CD4+ T cells in lymphoid follicles. Recently, Tfh cells were shown to play an important role in asthma through B cell differentiation.
Shogo Sakurai, Kazuki Furuhashi, Ryo Horiguchi, Fumiya Nihashi, Hideki Yasui, Masato Karayama, Yuzo Suzuki, Hironao Hozumi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Naoki Inui, Takafumi Suda   +12 more
doaj   +1 more source

CD4 + helper T cells endow cDC1 with cancer-impeding functions in the human tumor micro-environment

Nature Communications, 2023
The presence of classical type 1 dendritic cells (cDC1) positively influences prognosis in cancer, but their intricate networking with the various T cell types found in the tumour microenvironment is not fully appreciated. Here the authors show that cDC1
Xin Lei, Indu Khatri, Tom de Wit, Iris de Rink, Marja Nieuwland, Ron Kerkhoven, Hans van Eenennaam, Chong Sun, Abhishek D. Garg, Jannie Borst, Yanling Xiao   +10 more
doaj   +1 more source