Results 1 to 10 of about 22,951 (177)

CXCR5 Signals Fine-Tune Dendritic Cell Transcription and Regulate T_H2 Development [PDF]

Vaccines
Background/Objectives: We previously demonstrated that dendritic cell (DC) expression of CXCR5 is required for TH2 priming in mice infected with the helminth Heligmosomoides polygyrus (Hp).
Miranda L. Curtiss, Natalia Ballesteros Benavides, Alexander F. Rosenberg, Christopher D. Scharer, Beatriz León, Frances E. Lund   +5 more
doaj   +2 more sources

Unraveling porcine dendritic-cell diversity: welcome tDC and DC3 [PDF]

Frontiers in Immunology
Dendritic cells (DC) are professional antigen presenting cells playing a major role in orchestrating adaptative immune responses. To adapt to various immune challenges, such as different classes of pathogens, specialized subsets of DC have evolved across
Ambre Baillou, Ambre Baillou, Gaël Auray, Gaël Auray, Francisco Brito, Francisco Brito, Marius Botos, Marius Botos, Alizée Huber, Alizée Huber, Artur Summerfield, Artur Summerfield, Stephanie C. Talker, Stephanie C. Talker   +13 more
doaj   +2 more sources

Role of cDC2 in priming CD8+ T cells in cancer [PDF]

Journal for ImmunoTherapy of Cancer
Type 2 conventional dendritic cell (cDC2) gene signature was shown to be associated with better overall survival in patients with lung cancer and a fraction of patients with breast carcinoma, indicating that they may possess antitumoral function ...
Damya Laoui, Ahmed E I Hamouda
doaj   +2 more sources

Structural Basis of MERS‐CoV Receptor Interactions and Antibody Neutralisations [PDF]

Rev Med Virol
ABSTRACT Increasing outbreaks of coronaviruses underscore the importance of antivirals and vaccines that can combat a wide range of coronaviruses. Neutralising antibodies (nAbs), along with vaccines and small‐molecule drugs, are among the most promising treatments and prevention options against coronaviruses.
Gavor E, Choong Y, Singh S, Sivaraman H, Yin E, Sivaraman J.   +5 more
europepmc   +2 more sources

Natriuretic peptides as novel regulators of dendritic cells-mediated inflammation [PDF]

Cellular and Molecular Life Sciences
Natriuretic Peptides (NPs), including atrial (ANP) and brain (BNP) types, exert pleiotropic effects in regulating immune responses via the Natriuretic Peptide Receptor-1 (NPR1), expressed across various immune cells.
Giorgia Manni, Estevao Carlos Silva Barcelos, Doriana Ricciuti, Benedetta Pieroni, Marco Gargaro, Giulia Mencarelli, Hans Acha-Orbea, Vincenzo Nicola Talesa, Letizia Mezzasoma, Francesca Fallarino   +9 more
doaj   +2 more sources

Granulocyte-macrophage colony-stimulating factor may contribute to spondyloarthritis development in HLA-B27 transgenic rat by affecting conventional dendritic cells function [PDF]

Arthritis Research & Therapy
Background Spondyloarthritis (SpA) is a chronic inflammatory disorder with axial and peripheral manifestations. A strong association between HLA-B27 and SpA has been known for more than 50 years.
Amel Ait Ali Said, Chiara Rizzo, Hendrick Mambu Mambueni, Félicie Costantino, Maxime Breban, Simon Glatigny   +5 more
doaj   +2 more sources

Absence of Batf3 reveals a new dimension of cell state heterogeneity within conventional dendritic cells

iScience, 2021
Summary: Conventional dendritic cells (cDCs) are traditionally subdivided into cDC1 and cDC2 lineages. Batf3 is a cDC1-required transcription factor, and we observed that Batf3−/− mice harbor a population of cDC1-like cells co-expressing cDC2-associated ...
Samuel W. Lukowski, Inga Rødahl, Samuel Kelly, Meihua Yu, James Gotley, Chenhao Zhou, Susan Millard, Stacey B. Andersen, Angelika N. Christ, Gabrielle Belz, Ian H. Frazer, Janin Chandra   +11 more
doaj   +1 more source

The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe [PDF]

Open Biology, 2011
Target of rapamycin complexes (TORCs), which are vital for nutrient utilization, contain a catalytic subunit with the phosphatidyl inositol kinase-related kinase (PIKK) motif.
Nobuyasu Ikai, Norihiko Nakazawa, Takeshi Hayashi, Mitsuhiro Yanagida   +3 more
doaj   +1 more source

Conventional type 2 lung dendritic cells are potent inducers of follicular helper T cells in the asthmatic lung

Allergology International, 2021
Background: Follicular helper T (Tfh) cells represent a unique subset of helper CD4+ T cells in lymphoid follicles. Recently, Tfh cells were shown to play an important role in asthma through B cell differentiation.
Shogo Sakurai, Kazuki Furuhashi, Ryo Horiguchi, Fumiya Nihashi, Hideki Yasui, Masato Karayama, Yuzo Suzuki, Hironao Hozumi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Naoki Inui, Takafumi Suda   +12 more
doaj   +1 more source

Optimization of the analogue-sensitive Cdc2/Cdk1 mutant by in vivo selection eliminates physiological limitations to its use in cell cycle analysis [PDF]

Open Biology, 2014
Analogue-sensitive (as) mutants of kinases are widely used to selectively inhibit a single kinase with few off-target effects. The analogue-sensitive mutant cdc2-as of fission yeast (Schizosaccharomyces pombe) is a powerful tool to study the cell cycle ...
Yuki Aoi, Shigehiro A. Kawashima, Viesturs Simanis, Masayuki Yamamoto, Masamitsu Sato   +4 more
doaj   +1 more source