Results 11 to 20 of about 22,951 (177)

Raptor is phosphorylated by cdc2 during mitosis. [PDF]

PLoS ONE, 2010
The appropriate control of mitotic entry and exit is reliant on a series of interlocking signaling events that coordinately drive the biological processes required for accurate cell division.
Dana M Gwinn, John M Asara, Reuben J Shaw   +2 more
doaj   +5 more sources

STAT3 signaling modulates the immune response induced after antigen targeting to conventional type 1 dendritic cells through the DEC205 receptor

Frontiers in Immunology, 2022
Conventional dendritic cells (cDC) are a group of antigen-presenting cells specialized in priming T cell responses. In mice, splenic cDC are divided into conventional type 1 DC (cDC1) and conventional type 2 (cDC2).
Fernando Bandeira Sulczewski, Larissa Alves Martino, Davi Salles, Márcio Massao Yamamoto, Daniela Santoro Rosa, Daniela Santoro Rosa, Silvia Beatriz Boscardin, Silvia Beatriz Boscardin   +7 more
doaj   +1 more source

Communication between Cyclin-dependent kinase Cdc2 and the Wis1-Spc1 MAPK pathway determines mitotic timing in Schizosaccharomyces pombe

Biology Open, 2020
Checkpoint activation and gene expression modulation represent key determinants of cellular survival in adverse conditions. The former is regulated by cyclin-dependent kinases (CDKs) while the latter can be controlled by mitogen-activated protein kinases
Agamani Ghosal, Priyanka Sarkar, Geetanjali Sundaram   +2 more
doaj   +1 more source

Role of cyclin B1/Cdc2 up-regulation in the development of mitotic prometaphase arrest in human breast cancer cells treated with nocodazole. [PDF]

PLoS ONE, 2011
During a normal cell cycle, the transition from G₂ phase to mitotic phase is triggered by the activation of the cyclin B1-dependent Cdc2 kinase. Here we report our finding that treatment of MCF-7 human breast cancer cells with nocodazole, a prototypic ...
Hye Joung Choi, Masayuki Fukui, Bao Ting Zhu   +2 more
doaj   +1 more source

Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2. [PDF]

Proceedings of the National Academy of Sciences, 1990
The human anti-oncoprotein p53 is shown to be a substrate of cdc2. The primary site of phosphorylation is serine-315. Serine-315 is phosphorylated by both p60-cdc2 and cyclin B-cdc2 enzymes. The phosphorylation of p53 is cell cycle-dependent. The abundance of p53 also oscillates during the cell cycle.
J R, Bischoff, P N, Friedman, D R, Marshak, C, Prives, D, Beach   +4 more
openaire   +2 more sources

Phosphatase PTPN22 Regulates Dendritic Cell Homeostasis and cDC2 Dependent T Cell Responses

Frontiers in Immunology, 2020
Dendritic cells (DCs) are specialized antigen presenting cells that instruct T cell responses through sensing environmental and inflammatory danger signals.
Harriet A. Purvis, Fiona Clarke, Anna B. Montgomery, Chloe Colas, Jack A. Bibby, Georgina H. Cornish, Xuezhi Dai, Xuezhi Dai, Xuezhi Dai, Diana Dudziak, David J. Rawlings, David J. Rawlings, David J. Rawlings, Rose Zamoyska, Pierre Guermonprez, Pierre Guermonprez, Andrew P. Cope   +16 more
doaj   +1 more source

Saponin-based adjuvants enhance antigen cross-presentation in human CD11c+ CD1c+ CD5− CD163+ conventional type 2 dendritic cells

Journal for ImmunoTherapy of Cancer, 2023
Background Adjuvants are key for effective vaccination against cancer and chronic infectious diseases. Saponin-based adjuvants (SBAs) are unique among adjuvants in their ability to induce robust cell-mediated immune responses in addition to antibody ...
Harry Dolstra, Gosse J Adema, Nataschja I Ho, Lisa G M Huis in 't Veld, Jesper van Eck van der Sluijs, Branco M H Heuts, Maaike W G Looman, Esther D Kers-Rebel, Koen van den Dries, Joost H A Martens, Willemijn Hobo   +10 more
doaj   +1 more source

TIM-3 increases the abundance of type-2 dendritic cells during Leishmania donovani infection by enhancing IL-10 production via STAT3

Cell Death and Disease, 2023
The outcome of the disease visceral leishmaniasis (VL), caused by Leishmania donovani (LD), largely relies on the relative dominance of host-protective type-1 T helper (Th1) cell response versus disease-promoting type-2 T helper (Th2) cell response.
Manish Mishra, Manisha Yadav, Sandeep Kumar, Raj Kumar, Pradip Sen   +4 more
doaj   +1 more source

Interaction of Type 1 Porcine Reproductive and Respiratory Syndrome Virus With In Vitro Derived Conventional Dendritic Cells

Frontiers in Immunology, 2021
The present study delineates the interaction of a typical PRRSV1.1 isolate 3267 (moderate virulence) with in vitro derived pig conventional dendritic cells, cDC1, cDC2, and a CD14+ population (designated as CD14+ DCs).
Yanli Li, Enric Mateu, Enric Mateu
doaj   +1 more source

Thr-161 Phosphorylation of Monomeric Cdc2 [PDF]

Journal of Biological Chemistry, 2002
Fully grown Xenopus oocyte is arrested at prophase I of meiosis. Re-entry into meiosis depends on the activation of MPF (M-phase promoting factor or cyclin B·Cdc2 complex), triggered by progesterone. The prophase-arrested oocyte contains a store of Cdc2.
de Smedt, Veronique, Poulhe, Robert, Cayla, Xavier, Dessauge, Frederic, Karaiskou, Anthi, Jessus, Catherine, Ozon, René   +6 more
openaire   +3 more sources